I-Pepsinogen Iikhiqizwa futhi ikhiqizwe ngamaseli ayinhloko esifundeni se-oxyntic glandular sesisu, kanti i-pepsinogen II ikhiqizwe futhi ikhiqizwe yisifunda se-pyloric sesisu. Womabili asebenza kuma-pepsin ku-lumen yesisu yi-HCl ekhiqizwe ngamaseli e-fundic parietal.

1. Iyini i-pepsinogen II?
I-Pepsinogen II ingenye yama-proteinase amane e-aspartic: i-PG I, i-PG II, i-Cathepsin E kanye ne-D. I-Pepsinogen II ikhiqizwa ikakhulukazi ku-mucosa ye-Oxyntic gland yesisu, i-gastric antrum kanye ne-duodenum. Ikhishwa kakhulu ku-lumen yesisu kanye nokujikeleza kwegazi.
2. Yiziphi izingxenye ze-pepsinogen?
Ama-Pepsinogen aqukethe uchungechunge olulodwa lwe-polypeptide olunesisindo sama-molecule esingaba ngu-42,000 Da. Ama-Pepsinogen akhiqizwa futhi akhiqizwe ngokuyinhloko ngamaseli ayinhloko esiswini somuntu ngaphambi kokuba aguqulwe abe yi-enzyme ye-proteolytic i-pepsin, ebaluleke kakhulu ezinqubweni zokugaya ukudla esiswini.
3. Uyini umehluko phakathi kwe-pepsin ne-pepsinogen?
I-Pepsin iyi-enzyme yesisu ekhonza ukugaya amaprotheni atholakala ekudleni okudliwe. Amaseli amakhulu esisu akhipha i-pepsin njenge-zymogen engasebenzi ebizwa ngokuthi i-pepsinogen. Amaseli e-parietal ngaphakathi kwesisu akhipha i-hydrochloric acid ehlisa i-pH yesisu.

Ikhithi Yokuxilonga yePepsinogen I/PepsinogenII (Ukuhlolwa Kwe-Fluorescence Immuno)iyi-fluorescence immunochromatographic assay yokuthola inani le-PGI/PGII ku-serum noma ku-plasma yomuntu, isetshenziswa kakhulu ukuhlola ukusebenza kweseli le-gastric oxyntic gland kanye nesifo se-gastric fundus mucinous gland emtholampilo.

Siyakwamukela ukuxhumana nathi ukuze uthole imininingwane eyengeziwe.