ISIFINYEZO

Njengeprotheyini yesigaba esibukhali, i-serum amyloid A iyingxenye yamaprotheni ahlukene omndeni we-apolipoprotein, abizwa ngokuthi
inesisindo sama-molecule esilinganiselwe esingaba ngu-12000. Ama-cytokine amaningi ahilelekile ekulawulweni kokubonakaliswa kwe-SAA
empendulweni yesigaba esiphuthumayo. Kushukunyiswa yi-interleukin-1 (IL-1), i-interleukin-6 (IL-6) kanye ne-tumor necrosis factor-α
(TNF-α), i-SAA yenziwa ngama-macrophage asebenzayo kanye ne-fibroblast esibindini, esinokuphila okufushane kwesigamu sempilo kuphela
cishe imizuzu engama-50. I-SAA ihlangana ne-high-density lipoprotein (HDL) egazini ngokushesha lapho ihlanganiswa esibindini, okuyinto
kudinga ukuwohloka yi-serum, ubuso beseli kanye nama-protease angaphakathi kweseli. Uma kwenzeka ezinye izifo ezibukhali nezingapheli
ukuvuvukala noma ukutheleleka, izinga lokuwohloka kwe-SAA emzimbeni ngokusobala liyehla ngenkathi ukwenziwa kukhuphuka,
okuholela ekukhuleni okuqhubekayo kokuhlushwa kwe-SAA egazini. I-SAA iyiprotheni yesigaba esibukhali kanye nokuvuvukala
uphawu olukhiqizwa yi-hepatocytes. Ukuhlushwa kwe-SAA egazini kuzokwanda phakathi namahora ambalwa uma
ukuvuvukala, kanye nokuhlushwa kwe-SAA kuzokwanda ngokuphindwe kayi-1000 ngesikhathi sokuhlasela okukhulu.
ukuvuvukala. Ngakho-ke, i-SAA ingasetshenziswa njengesibonakaliso sokutheleleka ngamagciwane noma ukuvuvukala okuhlukahlukene, okubangela
kungasiza ekuxilongweni kokuvuvukala kanye nokuqapha imisebenzi yokwelapha.

Ikhithi yethu Yokuxilonga ye-Serum Amyloid A (Fluorescence Immunochromatographic Assay) iyasebenza ekutholakaleni kwe-antibody kuya ku-serum amyloid A (SAA) ngaphakathi kwesibeletho ku-serum/plasma/isampula yegazi lonke lomuntu, futhi isetshenziselwa ukuxilongwa okusizayo kokuvuvukala noma ukutheleleka okubukhali nokungapheli.

Siyakwamukela ukuthi uxhumane nathi ukuze uthole imininingwane eyengeziwe uma unesithakazelo.