ISIFINYEZO

Njengeprotheni yesigaba esibucayi, i-serum amyloid A ingeyamaprotheni ahlukahlukene omndeni we-apolipoprotein, okuthi
inesisindo samangqamuzana esihlobene cishe. 12000. Ama-cytokine amaningi abandakanyeka ekulawuleni isisho se-SAA
ekuphenduleni kwesigaba esibucayi. Ikhuthazwa yi-interleukin-1 (IL-1), i-interleukin-6 (IL-6) kanye ne-tumor necrosis factor-α
(TNF-α), i-SAA ihlanganiswa ngama-macrophage acushiwe kanye ne-fibroblast esibindini, enohhafu wempilo emfushane kuphela.
cishe imizuzu engama-50. Amabhondi e-SAA ane-high-density lipoprotein (HDL) egazini ngokushesha ekuhlanganisweni kwesibindi, okuthi
idinga ukucekelwa phansi yi-serum, i-cell surface kanye ne-intracellular proteases. Esimeni esithile esibucayi futhi esingamahlalakhona
ukuvuvukala noma ukutheleleka, izinga lokuwohloka kwe-SAA emzimbeni ngokusobala liyancipha ngenkathi ukuhlangana kukhuphuka,
okuholela ekwenyukeni okuqhubekayo kwe-SAA egazini. I-SAA iyiphrotheni yesigaba esibucayi kanye nokuvuvukala
umaka ohlanganiswe nama-hepatocyte. Ukugxila kwe-SAA egazini kuzokwenyuka phakathi namahora ambalwa
ukuvuvukala, futhi ukugxila kwe-SAA kuzokwanda izikhathi eziyi-1000 ngesikhathi esibucayi
ukuvuvukala. Ngakho-ke, i-SAA ingasetshenziswa njengenkomba ye-microbial infection noma ukuvuvukala okuhlukahlukene, okuyinto
kungenza kube lula ukuxilongwa kokuvuvukala nokuqapha imisebenzi yokwelapha.

Ikhithi yethu yokuxilonga yeSerum Amyloid A (i-Fluorescence Immunochromatographic Assay) iyasebenza ekutholweni komthamo we-in vitro we-antibody ku-serum amyloid A (SAA) ku-serum yomuntu/i-plasma/isampula legazi lonke, futhi isetshenziselwa ukuxilongwa okusizayo kokuvuvukala okunamandla nokungapheli noma ukutheleleka.

Siyakwamukela koxhumana naye ukuze uthole imininingwane eyengeziwe uma unentshisekelo.