Ukubeka kafushane

Njengeprotheni yesigaba esibuhlungu, i-serum amyloid a ingeyamaprotheni ama-heterogeneous womndeni we-apolipoprotein, okuyinto
inesisindo esilinganayo se-approx. I-12000. Ama-cytokines amaningi ayabandakanyeka ekuqondisweni kwenkulumo yeSAA
ekuphenduleni kwesigaba esikhulu. Ivuselelwe yi-Interleukin-1 (IL-1), I-Interleukin-6 (IL-6-6) ne-tumor necrosis factor-α
(TNF-α), i-SAA ihlelwe nguMacrophages ocushiwe kanye ne-fibroblast ngesibindi, esinempilo emfushane ye-Half-yempilo kuphela
cishe imizuzu engama-50. Amabhondi e-SAA ane-lipoprotein ephezulu (HDL) egazini ngokushesha lapho u-synthesis esibindini, okuyinto
idinga ukudilizwa yi-serum, indawo yeseli kanye ne-interracellular proteres. Uma kwenzeka ubuqiniso obuthile futhi obungapheli
Ukuvuvukala noma ukutheleleka, izinga lokucekelwa phansi kwe-SAA emzimbeni ngokusobala liyehla ngenkathi ukuhlanganiswa kukhuphuka,
okuholela ekukhuphukeni okuqhubekayo e-SAA ukugxishwa kwegazi. I-SAA iyiprotheni yesigaba esibuhlungu kanye nokuvuvukala
umaka synthesses ngama-hepatocytes. Ukuhlushwa kwe-SAA ngegazi kuzokwanda kungakapheli amahora ambalwa ku
ukwenzeka kokuvuvukala, kanye nokuhlushwa kwe-SAA kuzothola ukwanda kwezikhathi eziyi-1000 ngesikhathi se-acute
ukuvuvukala. Ngakho-ke, iSAA ingasetshenziswa njengenkomba yokutheleleka nge-microbial noma ukuvuvukala okuhlukahlukene, okuyinto
Ingenza lula ukuxilongwa kokuvuvukala kanye nokuqapha kwemisebenzi yokwelapha.

Ikhilothi yethu yokuxilonga ye-serum amyloid a Ukutheleleka.

Uyemukelwa ukuxhumana ngemininingwane eminingi uma unentshisekelo.