I-Sepsis yaziwa ngokuthi "umbulali othule". Kungase kube okungajwayelekile kubantu abaningi, kodwa empeleni akukude nathi. Kuyimbangela enkulu yokufa kwabantu ngenxa yokutheleleka emhlabeni wonke. Njengesifo esibucayi, Izinga lokugula nokufa kwe-sepsis lihlala liphezulu. Kulinganiselwa ukuthi balinganiselwa ezigidini ezingu-20 kuya kwezingu-30 izigameko ze-sepsis emhlabeni wonke unyaka ngamunye, futhi umuntu oyedwa ulahlekelwa ukuphila kwakhe cishe njalo emizuzwaneni emi-3 kuya kwemi-4.

Njengoba izinga lokufa kwe-sepsis landa ngamahora, isikhathi sibalulekile ekwelapheni i-sepsis, futhi ukuhlonzwa kokuqala kwe-sepsis kuye kwaba yingxenye ebaluleke kakhulu yokwelashwa. Eminyakeni yamuva nje, i-heparin-binding protein (HBP) ifakazelwe ukuthi ingenye yezimpawu ezisafufusa zokuxilonga ukutheleleka kwamagciwane, esiza odokotela ukuthi babone iziguli ze-sepsis ngokushesha ngangokunokwenzeka futhi bathuthukise imiphumela yokwelashwa.

• Ukuhlonza Amagciwane Nokutheleleka Ngegciwane

Ngenxa yokuthi i-HBP iqala ukukhululwa kusukela esigabeni sokuqala sokutheleleka ngamagciwane, ukutholwa kwe-HBP kunganikeza ubufakazi bokwelapha basemtholampilo kusenesikhathi, ngaleyo ndlela kunciphise izehlakalo zokutheleleka okunzima kwamagciwane kanye ne-sepsis. Ukutholwa okuhlanganisiwe kwe-HBP kanye nezimpawu zokuvuvukala ezivame ukusetshenziswa kungathuthukisa ukunemba kokuxilonga.

• Ukuhlolwa kobunzima bokutheleleka nge-HBP

ukugxilisa ingqondo kuhambisana kahle nokuqina kokutheleleka futhi kungasetshenziswa ukuhlola ukuqina kokutheleleka.

• Isiqondiso ekusetshenzisweni kwezidakamizwa

I-HBP ingabangela ukuvuza kwemithambo kanye ne-tissue edema. Njengesici esiyimbangela, kuyingozi kakhulu izidakamizwa ezifana ne-heparin ne-albumin ukwelapha ukungasebenzi kwezitho zomzimba. Izidakamizwa ezinjenge-albumin, i-heparin, amahomoni, i-simvastatin, i-tizosentan, ne-dextran sulfate zingalehlisa ngempumelelo izinga le-plasma HBP ezigulini.

Isivivinyo se-baysenrapid sinemikhiqizo eminingi engasetshenziselwa ukuxilongwa kusenesikhathi kwe-HBP njengeI-CRP/SAA/PCT quick test kit.Siyakwamukela ukuthintana ukuze uthole imininingwane eyengeziwe.