I-Sepsis yaziwa ngokuthi “umbulali othule”. Ingase ingajwayelekile kubantu abaningi, kodwa empeleni ayikude nathi. Iyimbangela eyinhloko yokufa ngenxa yokutheleleka emhlabeni jikelele. Njengesifo esibucayi, izinga lokugula nokufa kwe-sepsis lihlala liphezulu. Kulinganiselwa ukuthi kunezimo ze-sepsis ezingaba yizigidi ezingu-20 kuya kwezingu-30 emhlabeni wonke minyaka yonke, futhi umuntu oyedwa ulahlekelwa impilo yakhe cishe njalo ngemizuzwana emi-3 kuya kwemi-4.

Njengoba izinga lokufa ngenxa ye-sepsis landa ngamahora, isikhathi sibaluleke kakhulu ekwelapheni i-sepsis, futhi ukuhlonza i-sepsis kusenesikhathi kube yingxenye ebaluleke kakhulu yokwelashwa. Eminyakeni yamuva nje, iphrotheni ebopha i-heparin (i-HBP) iye yafakazelwa ukuthi ingenye yezimpawu ezisafufusa zokuxilongwa kwangaphambi kwesikhathi kokutheleleka ngamagciwane, okusiza odokotela ukuthola iziguli ezine-sepsis kusenesikhathi futhi kuthuthukiswe imiphumela yokwelashwa.

• Ukuhlonza Ukutheleleka Kwamagciwane Namagciwane

Ngenxa yokuthi i-HBP iqala ukukhishwa kusukela esigabeni sokuqala sokutheleleka ngamagciwane, ukutholwa kwe-HBP kunganikeza ubufakazi bokwelashwa kwasekuqaleni, ngaleyo ndlela kuncishiswe ukwanda kokutheleleka ngamagciwane okukhulu kanye ne-sepsis. Ukutholwa okuhlanganisiwe kwe-HBP kanye nezimpawu zokuvuvukala ezisetshenziswa njalo kungathuthukisa ukunemba kokuxilonga.

• Ukuhlolwa kobucayi bokutheleleka kwe-HBP

Ukuhlushwa kuhlobene kahle nobukhali bokutheleleka futhi kungasetshenziswa ukuhlola ubunzima bokutheleleka.

• Isiqondiso ngokusetshenziswa kwezidakamizwa

I-HBP ingabangela ukuvuza kwemithambo yegazi kanye nokuvuvukala kwezicubu. Njengesici esibangela lokhu, iwumgomo ongaba khona wemithi efana ne-heparin ne-albumin ukwelapha ukungasebenzi kahle kwezitho zomzimba. Imithi efana ne-albumin, i-heparin, ama-hormone, i-simvastatin, i-tizosentan, kanye ne-dextran sulfate inganciphisa ngempumelelo izinga le-plasma HBP ezigulini.

Isivivinyo se-baysenrapid sinemikhiqizo eminingi engasetshenziswa ekuxilongweni kwe-HBP kusenesikhathi njengeI-CRP/SAA/PCT ikhithi yokuhlola okusheshayo. Siyakwamukela ukuthi uxhumane nathi ukuze uthole imininingwane eyengeziwe.