Umdlavuza we-colorectal

Umdlavuza we-Colorectal (CRC, kufaka phakathi umdlavuza we-rector kanye nomdlavuza wekoloni) kungenye yezimo ezijwayelekile ezimbi zepheshana lesisu.

Umdlavuza wesisu waseChina ube yi- "National Killer Okokuqala", cishe ama-50% eziguli zomdlavuza wesisu e-china ezenzeka eChina, kwathi ezingama-60% eziphakathi futhi sekwedlule isikhathi.

Kungakhathaleki ukuthi i-New Mage noma Ukufa, inani eliphelele lomdlavuza wesisu sedlulile umdlavuza wamaphaphu. Umdlavuza wamathumbu uyelapheka kalula wonke umdlavuza ngokuhlola kusenesikhathi. Kungukuqala kokuqala kwabantu ukunqoba umdlavuza. Ama-5% kuphela ama-centercher we-Chinese Cleachectal atholakala kusenesikhathi, futhi ama-60-70% eziguli ezinomdlavuza we-colorectal kwatholakala ukuthi zinama-lymph node noma ama-metastate akude. Izinga lokuphinda libuye laliphakeme ngama-30%.

IJapan neSouth Korea nayo inezigameko eziphakeme zomdlavuza wesisu, kepha izinga lokuxilongwa kwalo langaphambili lingama-50-60%, futhi ngaphezu kwama-90% weziguli angalapheka. Ucwaningo lwasekhaya nolwamazwe omhlaba lukhombisa ukuthi izindlela zokuhlola umdlavuza zemibala zinganciphisa izehlakalo nokufa komdlavuza wemibala.

Eminyakeni yamuva, ngaphezu kweYurophu, eNyakatho Melika, eJapan, eSingapore, eSouth Korea, eTaiwan, naseHong Kong, kube nokuhlolwa kukazwelonke okuholwa nguhulumeni. Ukuhlolwa kusenesikhathi kokuxilongwa komdlavuza wesisu se-gastroiterinal kunethuba lokuphulukiswa ngokuphelele, ngokubaluleka okukhulu komphakathi kanye nenani lemakethe.

Ukuvela komdlavuza we-colorectal kuyinqubo ende ende. Kusuka kuma-polyps kuya kwe-hyperplasia engajwayelekile yomdlavuza, kuvame ukuthatha isikhathi eside, esinikeza isikhathi sokuhlolwa komdlavuza wezemibalali. Ukuhlola okusebenzayo nokungenelela kusenesikhathi kunganciphisa izehlakalo zomdlavuza ngo-60% kanye nezinga lokufa kuka-80%.

2, ukubaluleka kweCalprotectin ekuhlolweni kokusebenza kwamathumbu

I-Calprotectin iprotheni ethathwe yi-calcium-zinc-obling ethathwe kuma-neutrophils kanye nama-macrophages, ngesisindo samangqamuzana esingu-36,000, kwakhiwa i-heterodimer yi-association engeyona eye-covandent ye-MRP14 ye-MR14 ne-S100. Amaprotheni omndeni.

Ngezincwadi ezibanzi zokucwaninga kanye nokuqinisekiswa kwemitholampilo, iCalprotectin inokuzwela okuphezulu kokuthola umdlavuza we-colorectal futhi ayithintwa yisigaba se-tumor, esingatholakala ekuqaleni nangesikhathi se-asymptomatic. Ingasetshenziswa njengophawu lokuhlolwa komdlavuza we-Colectal Cancer.

Ukuzwela kwe-Fecal Calprotectin, ukuhlolwa kwe-Fecal Favolt Vala kanye ne-Serum CEA yomdlavuza we-Colorectal kwakungama-88.51%, 83.91% no-44.83%, ngokulandelana. Isilinganiso esihle sokuhlolwa kwegazi somoya we-fecal kanye ne-serum cea ezigulini D ne-Stage A kwakuphansi kakhulu kunalokho ezigulini C. Akekho umehluko omkhulu ngesilinganiso esihle se-Fecal Calprotectin ezigulini ezinezigaba ezahlukahlukene ze Izinduna.

Ukuzwela kokuxilongwa kweCalprotectin Fecal kokuthola umdlavuza we-rectal kufinyelele ku-92.7%, futhi inani elibi lokubikezela le-NPV lifinyelele ku-98.6%. I-Fecal Calprotectin yomdlavuza we-colorectal, ≥10mm ame-polyps ama-polyps aphelele inani le-NPV elibi le-NPV lifinyelele ku-97.2%.

Kuze kube manje, amazwe angaphezu kwama-20 afana ne-United States, eBrithani, eCanada, eFrance, iJalimane, neSwitzerland basebenzise iCalprotectin njengenkomba ebalulekile yokuhlola izifo zamathumbu, futhi kuhlolwe ukuvuvukala isifo samathumbu. Izimpawu ezibalulekile neziphulukisa zisetshenziswa kabanzi ekusebenzeni kwemitholampilo.

I-3, izinzuzo zeCalprotectin kanye ne-Fausting Blood ehlanganisiwe yokutholwa kokuhlolwa kobungozi bomdlavuza wamathumbu

1. Kulula ukusebenza: isampula eyodwa, imiphumela yokuhlola eminingi
2. Ayikhuphuli ubunzima bokusebenza kanye nezindleko zensimbi: ithuluzi libekwe, futhi imishini ifakwe ngokwezidingo.
3. Ukuzwela okuphezulu nokucaciswa: Inkomba yokuvuvukala, ukopha kwesisu
4. I-Early Screening Stage Advance: Khulisa amathuba okuhlolwa kwe-adenocarcinoma nama-polyps
5. Izindleko zokutholwa okuphansi, zingasetshenziswa njenge-drainage ye-colonoscopy
6. Ukuphikelela: Ukuhlolwa kwe-batch yonyaka

Izimpawu ezijwayelekile zomdlavuza we-colorectal:

Ukuvuvukala kwamathumbu - iCalprotectin, isigaba se-Dukes yisiguli esiteji A no-B Isilinganiso Sokuhlobisa Ukusebenzelana Nemimoya siphansi kakhulu kuneziguli ezinesiguli, izinga elihlukile le-Fecal Calprotectin.

Isopha i-gastroidwest - Igazi Lomoya, Ukudluliselwa. I-hearrhage ye-gastrointestinal isho ukulahleka kwegazi ngokusebenzisa ipheshana lesisu lezizathu ezahlukahlukene. Izimbangela ezijwayelekile zifaka ukuvuvukala kwendlela yokugaya ngokwayo, ukulimala kwemishini, isifo somoya, isimila, nezifo ze-visceral epheshana esiswini. Ukuhlolwa kwegazi okuhlelekile kuyindlela ejwayelekile futhi ebalulekile yokuxilonga ukopha kwesisu.

4, Indlela Yokuthola I-Fecal Calprotectin

I-Calprotectin Test Kit (I-Colloidal Gold Way) ingasetshenziswa yedwa ukuze ibone iCalprotectin kumasampula e-Human Stool Samples. Ingasetshenziswa futhi ngochungechunge lwe-WIZ lwe-Immunoasans.

I-Calprotectin Assay Kit (Fleorescence Immunochrotography) ingafinyelela ukutholwa kwamanani, amanani anembile amanani, kanye nobubanzi obubanzi obuqondile, ukuze kufinyelelwe umphumela wokuhlukanisa izifo zamathumbu.

Ikhithi yokuhlola ukufundwa kwemimoya (iColloidal Gold) isetshenziselwa ukutholwa kwe-hemoglobin yabantu ezindlebeni zomuntu, okulungele ukutholwa kokopha kwesisu.