I-Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), igciwane elibangela ubhubhane lwakamuva lwe-coronavirus 2019 (COVID-19), iyigciwane le-RNA elinomqondo omuhle, elinomugqa owodwa elinobukhulu be-genome obungaba ngu-30 kb. Izinhlobo eziningi ze-SARS-CoV-2 ezinezimpawu zokuguquka ezihlukile ziye zavela kulo lonke ubhubhane. Kuye ngokuthi zikhula kanjani iphrotheni, ezinye izinhlobo zibonise ukutheleleka okuphezulu, ukutheleleka, kanye nokuba yingozi.

Uhlu lwe-BA.2.86 lwe-SARS-CoV-2, olwaqala ukutholakala ngo-Agasti 2023, luhlukile ngokwe-phylogenetically kuhlu lwe-Omicron XBB olusakazwayo njengamanje, okuhlanganisa i-EG.5.1 kanye ne-HK.3. Uhlu lwe-BA.2.86 luqukethe izinguquko ezingaphezu kuka-30 kuphrotheni ye-spike, okubonisa ukuthi lolu hlu lunamandla amakhulu okugwema ukuzivikela komzimba okukhona kakade kwe-anti-SARS-CoV-2.

I-JN.1 (BA.2.86.1.1) uhlobo olusanda kuvela lwe-SARS-CoV-2 oluvela ohlwini lwe-BA.2.86. I-JN.1 iqukethe uguquko oluphawulekayo lwe-L455S kuphrotheni ye-spike kanye nezinye izinguquko ezintathu kumaprotheni angewona ama-spike. Izifundo ezihlola i-HK.3 kanye nezinye izinhlobo ze-"FLip" zikhombisile ukuthi ukuthola uguquko lwe-L455F kuphrotheni ye-spike kuhlotshaniswa nokwanda kokudluliselwa kwegciwane kanye nekhono lokugwema amasosha omzimba. Uguquko lwe-L455F kanye ne-F456L lubizwa ngokuthi """Phendula"ukuguqulwa kwezakhi zofuzo ngoba kushintsha izikhundla zama-amino acid amabili, abhalwe ukuthi F kanye no-L, kuphrotheni ye-spike.

Thina i-baysen medical singakunikeza ukuhlolwa kwe-covid-19 ukuze uyisebenzise ekhaya, wamukelekile ukuxhumana nathi ukuthola imininingwane eyengeziwe.