I-Severe acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2), okuyimbangela yesifo sakamuva se-coronavirus 2019 (COVID-19) bhubhane, igciwane le-RNA elinomucu owodwa elinomucu owodwa olingana no-30 kb. . Izinhlobonhlobo eziningi ze-SARS-CoV-2 ezinamasiginesha ahlukile okuguqukayo ziye zavela kulo lonke ubhubhane. Ngokuya ngokuma kwe-spike protein mutational landscape, okunye okuhlukile kubonise ukusuleleka okuphezulu, ukusuleleka, kanye ne-virulence.

Uhlu lozalo lwe-BA.2.86 lwe-SARS-CoV-2, olwaqala ukuhlonzwa ngo-Agasti 2023, luhlukile ngokwezakhi zofuzo ohlwini lozalo lwe-Omicron XBB olusabalalisa njengamanje, okuhlanganisa i-EG.5.1 ne-HK.3. Uhlu lozalo lwe-BA.2.86 luqukethe ukuguqulwa okungaphezu kuka-30 kuphrotheni ye-spike, okubonisa ukuthi lolu hlu lozalo lukwazi kakhulu ukubalekela ukuzivikela okukhona ngaphambili kwe-anti-SARS-CoV-2.

I-JN.1 (BA.2.86.1.1) iwuhlobo olusanda kuvela lwe-SARS-CoV-2 oluphuma ohlwini lozalo lwe-BA.2.86. I-JN.1 iqukethe uguquko oluphawulekayo lwe-L455S kuphrotheni ye-spike nezinye izinguquko ezintathu kumaprotheni angewona ama-spike. Ucwaningo oluphenya nge-HK.3 nokunye okuhlukile kwe-"FLip" lubonise ukuthi ukuthola ukuguqulwa kwe-L455F kuphrotheni ye-spike kuhlotshaniswa nokunwebeka kwegciwane kanye nekhono lokuzivikela komzimba. Izinguquko ze-L455F kanye ne-F456L ziteketiswa ”Phenya”ukuguqulwa kwezakhi zofuzo ngenxa yokuthi ashintsha ukuma kwama-amino acid amabili, abhalwe ukuthi F no-L, kuphrotheni ye-spike.

I-Webaysen medical ingahlinzeka ngokuhlolwa kwe-covid-19 ukuze isetshenziswe ekhaya, siyakwamukela ukuthintana nathi ukuze uthole imininingwane eyengeziwe.