I-Fecal Calprotectin (FC) iyiprotheni engama-36.5 Kda calcium-obda e-60% amaprotheni amaprotheni we-neutriplil futhi aqoqiwe futhi asebenze ezindaweni zokuvuvukala kwamathumbu futhi akhishwe kwizinduku.

I-FC inezinhlobonhlobo zezinto eziphilayo, kufaka phakathi imisebenzi ye-antibacterial, immunomodulary, kanye ne-antiprolingoverative. Ikakhulu, ukuba khona kwe-FC kuhlobene kakhulu nokufuduka kwama-neutrophils emgodini wesisu. Ngakho-ke, kuwuphawu oluwusizo lokuvuvukala kwamathumbu ukuthola ubukhona nobunzima bokuvuvukala kwamathumbu.

Kungathatha kuphela izinyathelo ezine ukuthuthukisa kusuka ekuvuvukeni kwamathumbu kumdlavuza: Ukuvuvukala kwamathumbu -> Ama-polypstes -> Adenoma - >> Umdlavuza wamathumbu. Le nqubo ithatha iminyaka noma amashumi eminyaka, ihlinzeka ngamathuba anele okuhlola izifo zamathumbu. Kodwa-ke, ngoba abantu abaningi abanaka ukuhlolwa kusenesikhathi, amacala amaningi omdlavuza wamathumbu atholakala esigabeni esithuthukile.

Ngokusho kwemininingwane egunyaziwe ekhaya nakwamanye amazwe, inani leminyaka emihlanu yokusinda komdlavuza wesikhashana wesikhashana lingafinyelela kuma-90% kuya ku-95%. Uma kuyi-carcinoma ku-situ (isigaba sokuqala), izinga lokulapha lisondele ku-100%. Izinga lokusinda kweminyaka emi-5 lomdlavuza we-tleast seft-stage lingaphansi kwe-10%. Le mininingwane iphakamisa ukuthi ukuhlolwa kusenesikhathi kubalulekile ekuthuthukiseni ukusinda kanye namanani okulapha iziguli ngomdlavuza wamathumbu. Njengamanje, abanye ochwepheshe bahlongoze ukuthi abantu abajwayelekile kufanele bahlolwe ekuqaleni komdlavuza wamathumbu ngemuva kweminyaka yobudala engama-40, futhi abantu abanomlando womndeni noma ezinye izingozi ezinobungozi obukhulu kufanele zihlolwe ekuqaleni.

I-Calprotectin Detection reagentIngabe umkhiqizo ongenazinhlungu, ongahlaseli, ongenakuhlasela osetshenziselwa ukuhlola izinga lokuvuvukala kwamathumbu futhi usize ekuhlolweni kwezifo ezihlobene nokuvuvukala (isifo sokuvuvukala, i-adenoma, umdlavuza we-adenoma, umdlavuza we-adenoma, umdlavuza we-adenoma, umdlavuza we-adenoma, umdlavuza we-adenoma). Uma ukuhlolwa kweCalprotectin kungenamihle, awudingi ukwenza ikholofonicopy ngaleso sikhathi. Uma umphumela wokuhlola unethemba, ungabi novalo olukhulu. Iningi lemiphumela ye-post-colonoscopy yizilonda ezinobumba ezinjenge-adenomas. Lezi zilonda zingaphathwa ngempumelelo ngokungenelela kusenesikhathi.