I-Fecal calprotectin (FC) iyiphrotheni ebopha i-calcium engu-36.5 kDa ehlanganisa u-60% wamaphrotheni e-neutrophil cytoplasmic futhi anqwabelana bese esebenza ezindaweni zokuvuvukala kwamathumbu futhi akhishelwe endle.

I-FC inezinto ezihlukahlukene zebhayoloji, okuhlanganisa imisebenzi yokulwa namagciwane, i-immunomodulatory, kanye ne-antiproliferative. Ikakhulukazi, ukuba khona kwe-FC kuhlobene ngokwesilinganiso nokufuduka kwama-neutrophils emgudwini wesisu. Ngakho-ke, kuwuphawu oluwusizo lokuvuvukala kwamathumbu ukuze kutholakale ubukhona nobukhulu bokuvuvukala emathunjini.

Kungase kuthathe izinyathelo ezine kuphela ukukhula kusukela ekuvuvukeni kwamathumbu kuya kumdlavuza: ukuvuvukala kwamathumbu -> ama-polyps amathumbu -> i-adenoma -> umdlavuza wamathumbu. Le nqubo ithatha iminyaka noma ngisho namashumi eminyaka, inikeza amathuba anele okuhlolwa kwezifo zamathumbu kusenesikhathi. Kodwa-ke, ngenxa yokuthi abantu abaningi abakunaki ukuhlolwa kusenesikhathi, izehlakalo eziningi zomdlavuza wamathumbu zitholakala sezisezingeni eliphezulu.

Ngokwemininingwane egunyaziwe ekhaya naphesheya kwezilwandle, izinga lokusinda leminyaka emi-5 lomdlavuza we-colorectal esigabeni sokuqala lingafinyelela ku-90% kuye ku-95%. Uma kuyi-carcinoma in situ (isigaba sokuqala), izinga lokwelapha lisondele ku-100%. Izinga lokusinda leminyaka emi-5 lomdlavuza we-colorectal wesigaba sekwephuzile lingaphansi kuka-10%. Le datha iphakamisa ngokuqinile ukuthi ukuhlolwa kusenesikhathi kubalulekile ukuze kuthuthukiswe amazinga okusinda kanye nokwelapha iziguli ezinomdlavuza wamathumbu. Njengamanje, abanye ochwepheshe baphakamise ukuthi abantu abajwayelekile kufanele bahlolelwe umdlavuza wamathumbu kusenesikhathi uma sebeneminyaka engu-40, futhi abantu abanomlando womndeni noma ezinye izinto ezisengozini enkulu kufanele bahlolwe kusenesikhathi.

I-Reagent yokuthola i-Calprotectiniwumkhiqizo ongenabuhlungu, ongahlaseli, osebenziseka kalula osetshenziselwa ukuhlola izinga lokuvuvukala kwamathumbu futhi usize ekuxilongeni izifo ezihlobene nokuvuvukala kwamathumbu (isifo sofuba, i-adenoma, umdlavuza we-colorectal). Uma ukuhlolwa kwe-calprotectin kungenayo, awudingi ukwenza i-colonoscopy okwamanje. Uma umphumela wokuhlolwa uthi unayo, ungesabi kakhulu. Iningi lemiphumela ye-post-colonoscopy yizilonda eziyingozi njenge-adenomas. Lezi zilonda zingalawuleka ngempumelelo ngokungenelela kusenesikhathi.