I-Fecal Calprotectin: Ithuluzi Elibalulekile Lokuhlonza Okuhlukile Kwezifo Eziphansi Zesisu

Emtholampilo, ukutholakala kwezifo eziphansi zesisu kuvame ukuba nezinselele, njengoba izifo eziningi (njengesifo samathumbu esivuvukalayo, i-irritable bowel syndrome, kanye ne-infectious enteritis) zinezimpawu ezifanayo, okwenza kube nzima ukuhlukanisa ngokunembile ngokusekelwe kuphela ezibonakalisweni zezokwelapha kanye nokuhlolwa okuvamile.I-calprotectin yendle (FC), i-biomarker enamandla aphezulu futhi engahlaseli, ibonise ukubaluleka okukhulu ekuxilongweni okuhlukile kwezifo eziphansi zesisu eminyakeni yamuva nje, yaba ithuluzi eliphumelelayo lokusiza ekwenzeni izinqumo zomtholampilo.

Kuyini I-Fecal Calprotectin?

I-Calprotectin iyiprotheni etholakala ku-cytoplasm yama-neutrophils. Lapho kuvela ukuvuvukala kwamathumbu, ama-neutrophils aya ku-mucosa yamathumbu futhi akhiphe i-calprotectin, okuholela ekwandeni okuphawulekayo kokuhlushwa kwawo endle. Ngenxa yokuqina kwayo okuphezulu kanye nokulula kokutholakala, i-FC ibonisa kahle izinga lokuvuvukala kwamathumbu, isiza ukuhlukanisa phakathi kwezifo zamathumbu ezivuvukalayo (isb., IBD) kanye nezimo ezingezona ezokuvuvukala (isb., IBS).

Izicelo Zokuxilonga Okuhlukile

1. Ukuhlukanisa phakathi kwesifo samathumbu esivuvukalayo (IBD) kanye nesifo samathumbu esicasulayo (IBS)
   I-IBD (kufaka phakathi isifo sikaCrohn kanye ne-ulcerative colitis) iyisifo sokuvuvukala kwamathumbu esingamahlalakhona, kuyilapho i-IBS iyisifo esingasebenzi kahle esingenazo izilonda eziphilayo. Amazinga e-FC avame ukuphakama kakhulu ezigulini ze-IBD (ngokuvamile adlula i-100 μg/g), kuyilapho lawo aku-IBS ngokuvamile engaphakathi kwebanga elijwayelekile (ngaphansi kuka-50 μg/g). Ngakho-ke, ukuhlolwa kwe-FC kungasebenza njengethuluzi lokuhlola lokuqala, kunciphisa izinqubo ezingadingekile ze-endoscopic, kunciphisa izindleko zokunakekelwa kwempilo, futhi kuthuthukise ukusebenza kahle kokuxilonga.
2. Ukuhlolwa komsebenzi wesifo se-IBD

Amazinga e-FC ahlobene kahle nomsebenzi wesifo ku-IBD. Ukuqapha okuqhubekayo kwe-FC kusiza ukuhlola ukusebenza kahle kokwelashwa nokubikezela ukubuyela emuva. Isibonelo, ukwehla kwe-FC ngesikhathi sokwelashwa kubonisa ukuvuvukala okulawulwayo, kuyilapho ukwanda okusha kungabonisa ukuphinda kwesifo, okuqondisa ukulungiswa kwamasu okwelashwa.

3. Ukwehlukaniswa kwe-enteritis ethelelanayo kwezinye izifo ezivuvukalayo

I-enteritis ethelelanayo (njenge-bacterial noma i-viral enteritis) nayo ingabangela i-FC ephezulu, kodwa amazinga ngokuvamile aphansi kunalawo aku-IBD futhi ancipha ngokushesha njengoba ukutheleleka kuxazululeka. Ukuqapha okunamandla kwe-FC kusiza ukuhlukanisa ukutheleleka kwesikhashana nezifo zokuvuvukala ezingamahlalakhona.

4. Ukuhlolwa Okusizayo Komdlavuza We-Colorectal

Nakuba i-FC ingeyona uphawu oluthile lomdlavuza we-colorectal, izimila zamathumbu zivame ukubandakanya ukusabela kokuvuvukala kwendawo, okuholela ekuphakameni okuncane kuya kokuphakathi ku-FC. Uma kuhlanganiswa nezinye izivivinyo (isb., i-colonoscopy), i-FC inganikeza ukuqonda okwengeziwe kokuxilonga.

Izinzuzo kanye nokulinganiselwa

Ukuhlolwa kwe-Fecal Calprotectin inikeza izinzuzo ezifana nokungangenisi ukungcola, ukusebenziseka kalula, kanye nezindleko eziphansi, okwenza ifaneleke kokubili ukuhlolwa kokuqala kanye nokuqapha isikhathi eside. Kodwa-ke, iphakanyisiwe.I-Fecal Cal akulona uhlobo oluthile lwe-IBD futhi kungabonakala nakwezinye izimo (njengokutheleleka kwamathumbu, izimila, kanye ne-enteropathy ehlobene nezidakamizwa ezingezona eze-steroidal ezilwa nokuvuvukala). Ngakho-ke, ukuhlolwa okuphelele okusekelwe ezibonakalisweni zemitholampilo, ukuhlolwa kwe-endoscopic, kanye nezifundo zezithombe kuyadingeka.

Isiphetho

I-calprotectin yendle Ukuhlolwa kunikeza isisekelo esibalulekile sokuhlonza ngokwehlukana izifo eziphansi zesisu, ikakhulukazi okusiza ukuhlukanisa i-IBD ne-IBS nokwenza ngcono ukuxilongwa nokwelashwa. Ngokuthuthuka kobuchwepheshe bokuhlola kanye nezicelo ezijulile zezokwelapha,i-calprotectin yendle izodlala indima enkulu ekuphathweni kwezifo zesisu, inikeze iziguli ukuxilongwa nokwelashwa okunembile nokuphumelelayo.

Ngokusebenzisa isayensii-calprotectin yendleNjengethuluzi, singakunikeza kangcono ukuxilongwa kwezokwelapha futhi sisize ekuphathweni nasekwelapheni izifo eziphansi zesisu.

I-Baysen MedicalKuhlala kugxilwe enkambisweni yokuxilonga ukuze kuthuthukiswe ikhwalithi yempilo. Sithuthukise amapulatifomu obuchwepheshe amahlanu - i-Latex, igolide le-colloidal, i-Fluorescence Immunochromatographic Assay, i-Molecular, i-Chemiluminescence Immunoassay. Ukuhlolwa okusheshayo kwe-CalprotectinfuthiMinaukuhlolwa kwe-mmunoassay Calprotectin ukuhlola ukulimala kwezinso esigabeni sokuqala.