Ukuphumelela Kokuhlola Okungahlaseli:I-Calprotectin ye-Fecal"Yeqa Imingcele" Ukuze Usize Ukuxilongwa Kwangaphambi Kokuvuvukala Kwe-GI Ephezulu Ezinganeni

Emkhakheni wokuxilongwa kwezifo zesistimu yokugaya ukudla kwezingane, i-endoscopy sekuyisikhathi eside "izinga legolide" lokunquma ukuvuvukala kwamathumbu aphezulu. Kodwa-ke, lokhu kuhlola okuphazamisayo akugcini nje ngokuhambisana nokungakhululeki ngokomzimba kubantwana, ikakhulukazi abasha, kodwa futhi ngokuvamile kuletha ukwesaba okukhulu kwengqondo nobunzima bokubambisana. Lokhu kwenza abazali abaningi babe manqikanqika ngesikhathi sokuxilongwa kokuqala futhi bangase baphuthelwe ithuba lokungenelela kusenesikhathi.Muva nje, ucwaningo olusha lomtholampilo kanye nokwenza isicelo kulethe izindaba ezijabulisayo:i-fecal calprotectin (FCP), inkomba evuthiwe engahlaseli yokuhlolwa kwezifo eziphansi zesisu, ibonisa amandla amakhulu ekuxilongweni kokuqala kokuvuvukala kwamathumbu emathunjini aphezulu ezinganeni, ukufeza "i-crossover" emangalisayo kusukela "emathunjini aphansi" kuya "emathunjini aphezulu".

Kusuka Enkingeni “Yezinga Legolide” ukuya Ekuseni Kokuhlolwa Okungahlaseli

Ukuvuvukala kwamathumbu emathunjini aphezulu okufana ne-gastritis kanye ne-gastroduodenitis akuvamile ezinganeni, futhi izimbangela zakho zihlanganisa ukutheleleka, izidakamizwa, nokusabela kokucindezeleka. Ngokwesiko, ukuxilongwa kudinga ukubhekwa okubonakalayo kanye ne-tissue biopsy nge-gastroscopy, okuyinqubo eyinkimbinkimbi futhi ehlaselayo. Izindlela zokuhlonza ezingahlaseli nezilula bezilokhu ziwukulindelwe okuvamile kodokotela nemindeni yezingane ezinalesi sifo.I-calprotectin ye-fecaliphrotheni ekhombisa ukuhlangana kwe-neutrophil. Lapho i-mucosa yamathumbu ivutha, ukugxila kwayo kuzokwanda kakhulu. Eminyakeni edlule, isetshenziswe kabanzi ekuhloleni umsebenzi wesifo sofuba (IBD) kanye nokuxilongwa okuhlukile kwe-irritable bowel syndrome (IBS), ikakhulukazi ukuvuvukala kwekholoni.

Ucwaningo lwesayensi luqinisekisa isisekelo esiqinile sezinhlelo zokusebenza "eziwela umngcele".

Indikimba ekhulayo yocwaningo ikhombisa ukuthi lo maki ovuvukalayo awukhethekile kukholoni. Lapho ukuvuvukala okusebenzayo kwenzeka endaweni engenhla yesisu (njengesisu kanye ne-duodenum), amangqamuzana okuvuvukala nawo angena futhi akhulule.i-calprotectin. Le phrotheni yehla ngomgudu wokugaya ukudla kanye noketshezi lokugaya ukudla nezinsalela zokudla, ekugcineni kutholakale esitulweni. Ucwaningo lwakamuva lwezingane lukhombisile lokhoi-calprotectin ye-fecalamazinga aphezulu kakhulu ezinganeni ezine-gastritis eqinisekisiwe ye-endoscopically noma i-duodenitis uma kuqhathaniswa nalabo abane-dyspepsia esebenzayo noma okutholakele okujwayelekile kwe-endoscopic.Nakuba amazinga e-FC aphakeme abangelwa ukuvuvukala kwamathumbu emathunjini aphezulu ngokuvamile aphansi kunalawo ase-IBD esebenzayo, abonise umehluko ophawulekayo wezibalo uma kuqhathaniswa nabantu abanempilo. Lokhu kuphakamisa ukuthi ukuhlolwa kwe-FC kungasetshenziswa njengethuluzi lokuhlola eliphumelelayo ukusiza odokotela ekuqaleni babone izingane ezisengozini enkulu yokuvuvukala kwe-organic upper gastrointestinal phakathi kwenani elikhulu lezingane ezethula izimpawu ezifana nobuhlungu besisu, ukuqunjelwa, nokucanuzela kwenhliziyo.

Inani Lomtholampilo: Ukwakha Indlela Engcono Yokuxilongwa Kwezingane

Ukusetshenziswa komngcele wei-calprotectin ye-fecalkulethe izinzuzo eziningi ekuxilongeni nasekulawuleni izifo ezingenhla zesisu ezinganeni:

1.Ukuthobela okungahlanyisi nokuphezulu: Kudingeka inani elincane kuphela lesampula lendle, futhi inqubo ayihlaseli ngokuphelele, okunciphisa kakhulu umthwalo ongokomzimba nongokwengqondo ezinganeni. Abazali bayayemukela kakhulu inqubo, okwenza kube lula ukwenza ukuqapha okuphindaphindiwe ngokushesha emitholampilo yeziguli ezingalaliswanga.
2. Ithuluzi elisebenzayo lokuhlola kanye ne-triage: Ezinganeni ezinezimpawu eziqhubekayo zesisu,I-Calprotectin ye-Fecalukuhlolwa kungenziwa kuqala ukuze kuhlukaniswe ngokuphumelelayo phakathi kwezifo ezivuthayo nezisebenzayo. UmaI-calprotectin ye-fecalamazinga ajwayelekile, izici zokusebenza zingabekwa eqhulwini noma ukwelashwa ngokwamandla futhi kuthathwe ukubhekwa. Uma amazinga e-FC ephakanyisiwe, inikeza isisekelo esiqinile se-gastroscopy ehlaselayo, ukugwema izinqubo ze-endoscopic ezingadingekile kanye nokwandisa ukwabiwa kwezinsiza zezokwelapha.
3. Ukuhlolwa okusizwayo kokusebenza kahle nokuphindaphinda: Ngemva kokuxilongwa kokuvuvukala kwamathumbu aphezulu kanye nokuqala kokwelashwa, ukuqapha okunamandla kwezinguqukoI-Calprotectin ye-Fecalamazinga angasebenza njengenkomba eyinkomba yokuhlola ukuthi ukuvuvukala kwehlile nokuthi ingabe ukwelashwa kusebenza kahle. Kungasiza futhi ukubona ukuvela kwezifo kusenesikhathi.

Ikusasa Outlook

Kunjalo, ukusetshenziswa kwe-fecal calprotectin endaweni engenhla yomzila wesisu kusadinga ucwaningo olwengeziwe ukuze kuchazwe ngokunembile inani layo elilungile lokusika futhi kukhishwe ezinye izici eziphansi zesisu ezingase zidale i-FC ephakeme. Kodwa-ke, njengendlela yokuhlola ephephile, elula, neshibhile, ngokungangabazeki ivula umnyango omusha wokuhlonza ukuvuvukala kwamathumbu emathunjini aphezulu ezinganeni. Kuphawula igxathu eliya phambili ekuhlonzweni kwezifo zokugaya ukudla kwezingane kubhekwe endleleni enobuntu nenembayo. Sikholelwa ukuthi ngocwaningo olujulile oluqhubekayo kanye nolwazi oluqoqiwe lwezokwelapha,i-calprotectin ye-fecal,le “crossover star,” izodlala indima ebaluleke ngokwengeziwe ekuvikeleni impilo yezingane yokugaya ukudla.

I-Baysen Medical ihlezi igxile kumasu okuxilonga ukuze kuthuthukiswe izinga lempilo. Senze izinkundla zobuchwepheshe ezi-5- i-Latex, igolide eli-colloidal, i-Fluorescence Immunochromatographic Assay, i-Molecular, i-Chemiluminescence Immunoassay.Sinegolide eliyi-ColloidalI-calprotectin ye-fecal ikhithi yokuhlola kanye ne-Fluorescence ImmunoassayIkhithi yokuhlola yeCalprotectinukuze kuhlolwe