Ukuhlola Okungahlaseli:I-Fecal Calprotectin"Yeqa imingcele" ukusiza ekuxilongweni kusenesikhathi kokuvuvukala kwe-GI ephezulu ezinganeni

Emkhakheni wokuxilonga izifo zesistimu yokugaya ukudla kwezingane, i-endoscopy ibilokhu "iyindinganiso yegolide" yokunquma ukuvuvukala kwesisu okuphezulu. Kodwa-ke, lokhu kuhlolwa okuhlaselayo akupheleli nje ekungakhululeki ngokomzimba kwezingane, ikakhulukazi ezincane, kodwa futhi kuvame ukuletha ukwesaba okukhulu kwengqondo kanye nobunzima ekubambisaneni. Lokhu kwenza abazali abaningi bangabaze ngesikhathi sokuxilongwa kokuqala futhi bangase baphuthelwe ithuba lokungenelela kusenesikhathi. Muva nje, ucwaningo olusha lwezokwelapha kanye nomkhuba wokusebenzisa ulethe izindaba ezijabulisayo:i-calprotectin yendle (i-FCP), isibonakaliso esivuthiwe esingahlaseli sokuhlola izifo zesisu esiphansi, sibonisa amandla amakhulu ekuxilongweni kokuqala kokuvuvukala kwesisu esingenhla ezinganeni, kufeza "ukudluliselwa" okuhle kakhulu kusukela "emathunjini angezansi" kuya "emathunjini angaphezulu".

Kusukela Enkingeni “Yezinga Legolide” Kuya Ekuqalekeni Kokuhlolwa Okungangeni Emhlabeni

Ukuvuvukala kwamathumbu okuphezulu njenge-gastritis kanye ne-gastroduodenitis akuvamile ezinganeni, futhi izimbangela zako zifaka phakathi ukutheleleka, izidakamizwa, kanye nokusabela kokucindezeleka. Ngokwesiko, ukuxilongwa kudinga ukubonwa ngamehlo kanye ne-biopsy yezicubu nge-gastroscopy, okuyinqubo eyinkimbinkimbi futhi ehlaselayo. Izindlela zokuthola ezingahlaseli futhi ezilula bezilokhu ziyilindelo elivamile lodokotela kanye nemindeni yezingane ezinalesi sifo.I-calprotectin yendleiyiprotheni ebonisa ukuhlanganiswa kwama-neutrophil. Lapho i-mucosa yamathumbu ivuvukele, ukuhlushwa kwayo kuzokhula kakhulu. Eminyakeni edlule, ibilokhu isetshenziswa kabanzi ekuhlolweni komsebenzi wesifo samathumbu esivuvukele (IBD) kanye nokuxilongwa okuhlukile kwe-irritable bowel syndrome (IBS), ikakhulukazi ekuvuvukeni kwamathumbu amakhulu.

Ucwaningo lwesayensi luqinisekisa isisekelo esiqinile sezicelo "ezingaphezu kwemingcele"

Ucwaningo olukhulayo lubonisa ukuthi lolu phawu lokuvuvukala alugcini nje ngomathumbu amakhulu. Lapho ukuvuvukala okusebenzayo kwenzeka endaweni ephezulu yokugaya ukudla (njengesisu kanye ne-duodenum), amaseli okuvuvukala nawo ayangena futhi akhululeke.i-calprotectin. Le phrotheni ihamba ngomgudu wokugaya ukudla kanye noketshezi lokugaya ukudla kanye nezinsalela zokudla, ekugcineni itholakale esitulweni. Izifundo zakamuva ezinganeni zibonise ukuthii-calprotectin yendleamazinga aphezulu kakhulu ezinganeni ezine-gastritis noma i-duodenitis eqinisekiswe yi-endoscopically uma kuqhathaniswa nalabo abane-dyspepsia yokusebenza noma imiphumela evamile ye-endoscopic. Nakuba amazinga aphezulu e-FC abangelwa ukuvuvukala kwesisu okuphezulu ngokuvamile ephansi kunalawo ane-IBD esebenzayo, abonise umehluko obalulekile ngokwezibalo uma kuqhathaniswa nabantu abanempilo. Lokhu kusikisela ukuthi ukuhlolwa kwe-FC kungasetshenziswa njengethuluzi lokuhlola eliphumelelayo ukusiza odokotela ekuqaleni ukuhlonza izingane ezisengozini enkulu yokuvuvukala kwesisu okuphezulu okungokwemvelo phakathi kwenani elikhulu lezingane ezibonisa izimpawu ezifana nobuhlungu besisu, ukuqunjelwa, kanye nesicanucanu.

Inani Lomtholampilo: Ukwakha Indlela Engcono Yokuxilonga Izingane

Ukusetshenziswa kwemingcele ye-i-calprotectin yendleKulethe izinzuzo eziningi ekuxilongweni nasekuphathweni kwezifo zesisu eziphezulu ezinganeni:

1. Akuhlaseli futhi kulandelwa imithetho ephezulu: Kudingeka inani elincane kuphela lesampula yendle, futhi inqubo ayihlaseli nhlobo, okunciphisa kakhulu umthwalo womzimba nowengqondo ezinganeni. Abazali bayayamukela kakhulu inqubo, okwenza kube lula ukwenza ukuqapha okuphindaphindiwe ngokushesha emitholampilo yangaphandle.
2. Ithuluzi lokuhlola elisebenzayo kanye nokuhlola: Ezinganeni ezinezimpawu eziqhubekayo zesisu,I-Fecal CalprotectinUkuhlolwa kungenziwa kuqala ukuze kuhlukaniswe ngempumelelo phakathi kwezifo zokuvuvukala nezisebenzayo.I-calprotectin yendleamazinga ajwayelekile, izici zokusebenza zingabekwa phambili noma ukwelashwa okubonakalayo kanye nokubuka kungathathwa. Uma amazinga e-FC ephakanyisiwe, kunikeza isisekelo esiqinile se-gastroscopy ehlaselayo, kugwenywe izinqubo ze-endoscopic ezingadingekile futhi kuthuthukiswe ukwabiwa kwezinsiza zezokwelapha.
3. Ukuhlolwa okusizwayo kokusebenza kahle kanye nokuphinda kuvele: Ngemva kokuxilongwa kokuvuvukala kwesisu okuphezulu kanye nokuqala kokwelashwa, ukuqapha okunamandla kwezinguquko kuI-Fecal Calprotectinamazinga angasebenza njengenkomba eqondile yokuhlola ukuthi ukuvuvukala sekuphelile yini nokuthi ukwelashwa kuyasebenza yini. Kungasiza futhi ekutholeni ukuphinda kwesifo kusenesikhathi.

Umbono Wesikhathi Esizayo

Yiqiniso, ukusetshenziswa kwe-calprotectin yendle endaweni ephezulu yokugaya ukudla kusadinga ucwaningo olwengeziwe ukuze kuchazwe ngokunembile inani layo elifanele lokuqeda futhi kukhishwe ezinye izici eziphansi zokugaya ukudla ezingase zibangele i-FC ephezulu. Kodwa-ke, njengendlela yokuhlola ephephile, elula, futhi engabizi kakhulu, ngokungangabazeki ivula umnyango omusha wokuxilongwa kwangaphambi kwesikhathi kokuvuvukala kwamathumbu aphezulu ezinganeni. Kuphawula isinyathelo esiya phambili ekuxilongweni kwezifo zokugaya ukudla zezingane eziya endleleni enobuntu neqondile. Sikholelwa ukuthi ngocwaningo olujulile oluqhubekayo kanye nokuhlangenwe nakho okuqoqiwe kwezokwelapha,i-calprotectin yendle,le "nkanyezi ehlanganisiwe," izodlala indima ebaluleke kakhulu ekuvikeleni impilo yokugaya ukudla kwezingane.

I-Baysen Medical ihlala igxile ebuchwephesheni bokuxilonga ukuze kuthuthukiswe ikhwalithi yempilo. Sithuthukise amapulatifomu obuchwepheshe amahlanu - i-Latex, igolide le-colloidal, i-Fluorescence Immunochromatographic Assay, i-Molecular, i-Chemiluminescence Immunoassay. Sinegolide le-ColloidalI-calprotectin yendle ikhithi yokuhlola kanye ne-Fluorescence ImmunoassayIkhithi yokuhlola yeCalprotectinukuhlolwa