I-C-Peptide, noma ukuxhumanisa i-peptide, i-amino acid emfushane edlala indima ebalulekile ekukhiqizweni kwe-insulin emzimbeni. Kungumkhiqizo owenziwe ngokukhiqizwa kwe-insulin futhi ukhishwe ama-pancreas ngamanani alinganayo kwi-insulin. Ukuqonda i-C-PEPTIVE kunganikeza ukuqonda okubalulekile ezimweni ezahlukahlukene zempilo, ikakhulukazi ushukela.

Lapho ama-pancreas akhiqiza i-insulin, ekuqaleni kukhiqiza i-molecule enkulu ebizwa ngokuthi i-proinsulin. I-ProISULIN bese ihlukana ibe izingxenye ezimbili: insulin kanye ne-C-peptide. Ngenkathi i-insulin isiza ukulawula amazinga kashukela wegazi ngokuqhakambisa ukukhuphuka kwe-glucose kumaseli, i-c-peptide ayinayo indima eqondile ku-glucose metabolism. Kodwa-ke, umaka obalulekile wokuhlola umsebenzi we-pancreatic.

Okunye kokusetshenziswa okuyinhloko kokulinganisa amazinga e-C-PETRIDE kukuxilongwa kanye nokuphathwa kwesifo sikashukela. Kubantu abanesifo sikashukela sohlobo 1, amasosha omzimba ahlasela futhi abhubhise amaseli akhiqiza ama-insulin kumanyikwe, okuholela emazingeni aphansi noma angabonakali we-insulin ne-c-peptide. Ngokuphambene, abantu abanesifo sikashukela sohlobo 2 bavame ukuba namazinga ajwayelekile noma aphakanyisiwe amazinga we-C-PETRIDE ngoba imizimba yabo ikhiqiza i-insulin kepha imelana nemiphumela yayo.

Izilinganiso ze-C-Peptide zingasiza futhi ukuhlukanisa phakathi kohlobo 1 noshukela wesifo sikashukela, ziqondise izinqumo zokwelashwa, futhi zibheke ukusebenza kokwelashwa. Isibonelo, isiguli esinesifo sikashukela sohlobo 1 esisebenza ngokufakelwa kweseli kwe-Ishlet kungenzeka ukuthi amazinga awo we-C-PETRIDE abhekiswe ekuhlolweni kwempumelelo yenqubo.

Ngaphezu kwesifo sikashukela, i-C-PEPTIDE ifundelwe imiphumela yayo yokuvimbela izicubu ezahlukahlukene. Ezinye izifundo zibonisa ukuthi kungenzeka ukuthi i-C-PETTITE ingahle ibe nezakhiwo zokulwa nokuvuvukala ezingasiza ukunciphisa izinkinga ezihambisana nesifo sikashukela, njengokulimala kwezinso nozinso.

Ekuphetheni, yize i-C-Peritide ngokwayo ayinawo ngokuqondile amazinga kashukela, kuyinto ebalulekile ye-biomarker yokuqonda nokuphatha isifo sikashukela. Ngokulinganisa amazinga e-C-PETRIDE, abahlinzeki bezokunakekelwa kwempilo bangathola ukuqonda ngomsebenzi we-pancreatic, bahlukanise phakathi kwezinhlobo zesifo sikashukela, kanye nezinhlelo zokwelashwa ezinomsila ezidingweni ngazinye.

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