I-C-peptide, noma ukuxhumanisa i-peptide, i-amino acid ene-short-chain edlala indima ebalulekile ekukhiqizeni i-insulin emzimbeni. Kungumkhiqizo wokukhiqizwa kwe-insulin futhi ikhishwa ama-pancreas ngamanani alinganayo ne-insulin. Ukuqonda i-C-peptide kunganikeza ukuqonda okubalulekile ezimweni ezehlukene zempilo, ikakhulukazi isifo sikashukela.

Lapho amanyikwe ekhiqiza i-insulin, aqale akhiqize i-molecule enkulu ebizwa ngokuthi i-proinsulin. I-Proinsulin ibe ihlukaniswa izingxenye ezimbili: i-insulin ne-C-peptide. Nakuba i-insulin isiza ekulawuleni amazinga kashukela egazini ngokukhuthaza ukungena kwe-glucose kumaseli, i-C-peptide ayinayo indima eqondile kumetabolism ye-glucose. Kodwa-ke, kuwuphawu olubalulekile lokuhlola ukusebenza kwe-pancreatic.

Enye yezindlela eziyinhloko ezisetshenziswayo ukukala amazinga e-C-peptide ekuhlonzweni nasekulawuleni isifo sikashukela. Kubantu abanesifo sikashukela sohlobo 1, amasosha omzimba ahlasela futhi abhubhise amaseli e-beta akhiqiza i-insulin kumanyikwe, okuholela emazingeni aphansi noma angabonakali e-insulin ne-C-peptide. Ngokuphambene, abantu abanesifo sikashukela sohlobo 2 bavame ukuba namazinga e-C-peptide avamile noma aphakeme ngoba imizimba yabo ikhiqiza i-insulin kodwa imelana nemiphumela yayo.

Izilinganiso ze-C-peptide zingasiza futhi ukuhlukanisa phakathi kohlobo loku-1 nohlobo 2 lwesifo sikashukela, ziqondise izinqumo zokwelashwa, nokuqapha ukusebenza ngempumelelo kokwelashwa. Isibonelo, isiguli esinesifo sikashukela sohlobo loku-1 esifakwe i-islet cell singase siqashwe amazinga aso e-C-peptide ukuze kuhlolwe impumelelo yenqubo.

Ngaphezu kwesifo sikashukela, i-C-peptide iye yacwaningwa ngemiphumela yayo engaba khona yokuvikela ezinhlobonhlobo zezicubu. Olunye ucwaningo lubonisa ukuthi i-C-peptide ingase ibe nezindawo zokulwa nokuvuvukala ezingasiza ekunciphiseni izinkinga ezihlobene nesifo sikashukela, njengokulimala kwemizwa nezinso.

Sengiphetha, nakuba i-C-peptide ngokwayo ingawathinti ngokuqondile amazinga kashukela egazini, iyisici esibalulekile sokuqonda nokulawula isifo sikashukela. Ngokulinganisa amazinga e-C-peptide, abahlinzeki bezokunakekelwa kwempilo bangathola ukuqonda ngokusebenza kwama-pancreas, bahlukanise phakathi kwezinhlobo zesifo sikashukela, futhi benze izinhlelo zokwelashwa ezifanelana nezidingo zomuntu ngamunye.

Sinayo iBaysen MedicalIkhithi yokuhlola i-C-peptide ,Ikhithi yokuhlola i-insulinfuthiIkhithi yokuhlola ye-HbA1Cokwesifo sikashukela