I-C-peptide, noma i-linking peptide, iyi-amino acid ye-short-chain edlala indima ebalulekile ekukhiqizweni kwe-insulin emzimbeni. Ingumkhiqizo ophuma ekukhiqizweni kwe-insulin futhi ikhishwa yi-pancreas ngokulingana ne-insulin. Ukuqonda i-C-peptide kunganikeza ukuqonda okubalulekile ngezimo ezahlukene zempilo, ikakhulukazi isifo sikashukela.

Uma i-pancreas ikhiqiza i-insulin, ekuqaleni ikhiqiza i-molecule enkulu ebizwa ngokuthi i-proinsulin. I-Proinsulin ibe isihlukana ibe izingxenye ezimbili: i-insulin kanye ne-C-peptide. Nakuba i-insulin isiza ukulawula amazinga kashukela egazini ngokukhuthaza ukumuncwa kwe-glucose emaseli, i-C-peptide ayinayo indima eqondile ekugayweni kwe-glucose. Kodwa-ke, iwuphawu olubalulekile lokuhlola umsebenzi we-pancreatic.

Enye yezindlela eziyinhloko zokusebenzisa ukukala amazinga e-C-peptide ukuxilonga nokuphatha isifo sikashukela. Kubantu abanesifo sikashukela sohlobo 1, amasosha omzimba ahlasela futhi abhubhise amaseli e-beta akhiqiza i-insulin kuma-pancreas, okuholela emazingeni aphansi noma angatholakali e-insulin ne-C-peptide. Ngokuphambene nalokho, abantu abanesifo sikashukela sohlobo 2 bavame ukuba namazinga e-C-peptide ajwayelekile noma aphezulu ngoba imizimba yabo ikhiqiza i-insulin kodwa imelana nemiphumela yayo.

Ukulinganiswa kwe-C-peptide kungasiza futhi ukuhlukanisa phakathi kwesifo sikashukela sohlobo 1 nohlobo 2, kuqondise izinqumo zokwelashwa, futhi kuqaphe ukusebenza kahle kokwelashwa. Isibonelo, isiguli esinesifo sikashukela sohlobo 1 esifakelwa iseli le-islet singase siqashwe amazinga aso e-C-peptide ukuze kuhlolwe impumelelo yenqubo.

Ngaphezu kwesifo sikashukela, i-C-peptide iye yacwaningwa ngemiphumela yayo engaba khona yokuvikela ezicutshini ezahlukahlukene. Ezinye izifundo ziphakamisa ukuthi i-C-peptide ingaba nezakhiwo zokulwa nokuvuvukala ezingasiza ekunciphiseni izinkinga ezihlobene nesifo sikashukela, njengokulimala kwemizwa nezinso.

Ekuphetheni, yize i-C-peptide ngokwayo ingathinti ngqo amazinga kashukela egazini, iyi-biomarker ebalulekile yokuqonda nokuphatha isifo sikashukela. Ngokulinganisa amazinga e-C-peptide, abahlinzeki bezempilo bangathola ukuqonda ngomsebenzi we-pancreatic, bahlukanise phakathi kwezinhlobo zesifo sikashukela, futhi bahlele izinhlelo zokwelapha ngokwezidingo zomuntu ngamunye.

Thina iBaysen Medical sinayoIkhithi yokuhlola i-C-peptide ,Ikhithi yokuhlola i-insulinfuthiIkhithi yokuhlola i-HbA1Cisifo sikashukela