Kuyini iCalprotectin?

I-Calprotectin iyiprotheni etholakala ngokwemvelo emzimbeni wakho, ikakhulukazi ngaphakathi kohlobo lweseli elimhlophe legazi elibizwa ngokuthi i-neutrophil. Lawa maseli ayingxenye yesimiso sakho somzimba sokuzivikela futhi agijimela ezindaweni zokuvuvukala noma ukutheleleka. Uma kukhona ukuvuvukala emathunjini, lawa ma-neutrophil ayasebenza futhi akhiphe i-calprotectin. Ngakho-ke, izinga le-calprotectin kusampula yendle lihlobene ngqo nenani lokuvuvukala endleleni yesisu (GI).

Kungani Kuhlolwa?

Isizathu esiyinhloko sokuhlolwa kwe-calprotectin ukusiza odokotela ukuhlukanisa phakathi kwezigaba ezimbili ezinkulu zezinkinga zamathumbu:

1. Isifo Sokuvuvukala Kwamathumbu (IBD): Lokhu kufaka phakathi izimo ezifana nesifo sikaCrohn kanye nesifo sofuba esiswini, lapho amasosha omzimba ehlasela khona ngephutha ulwelwesi lwendlela yokugaya ukudla, okubangela ukuvuvukala okungapheli.
2. I-Irritable Bowel Syndrome (IBS): Lesi yisifo esithinta ukusebenza kahle kwamathumbu lapho amathumbu ezwela khona futhi ebangela izimpawu ezifana nokuqaqamba nokuqunjelwa, kodwa akukho ukuvuvukala noma umonakalo obonakalayo.

Izimpawu ze-IBD kanye ne-IBS—njengobuhlungu besisu, uhudo oluqhubekayo, kanye nokuqunjelwa—zingafana kakhulu. Ukuhlolwa kwe-calprotectin kusebenza “njengophawu lokuvuvukala” oluwusizo ukuze kuqondiswe odokotela endleleni efanele.

Ukuhlolwa Kwenziwa Kanjani?

Ukuhlolwa kulula kakhulu futhi akuhlaseli. Kudinga isampula encane yendle kuphela, oyiqoqa ekhaya usebenzisa ikhithi ekhethekile enikezwe udokotela wakho noma ikliniki. Isampula bese ithunyelwa elabhorethri ukuze ihlaziywe. Lapho, ochwepheshe balinganisa ukugcwala kwe-calprotectin esitulweni, okuvame ukubikwa ngama-microgram ngegremu (µg/g).

Isho Ukuthini Imiphumela?

Izinga Elijwayelekile/Eliphansi: Umphumela ongaphakathi kwebanga elijwayelekile (ngokuvamile ngaphansi kuka-50 µg/g, kodwa umkhawulo oqondile ungahluka ngokwelebhu) usikisela ngokuqinile ukuthi ukuvuvukala okusebenzayo emathunjini akunakwenzeka. Lokhu kusekela ukuxilongwa kwesimo esingesona ukuvuvukala njenge-IBS.
Izinga Eliphezulu: Izinga eliphakeme le-calprotectin libonisa ukuthi kukhona ukuvuvukala endleleni ye-GI. Lokhu kudinga uphenyo olwengeziwe ukuze kutholakale imbangela. Nakuba kuyisibonakaliso esinamandla se-IBD, amazinga aphezulu angavela nakwezinye izimo ezifana nokutheleleka ngamagciwane, i-colitis, noma ngisho nomdlavuza wamathumbu amakhulu. Ngakho-ke, akuyona ithuluzi lokuxilonga eliqondile lesifo esithile kodwa liyisiqondiso esibalulekile.
Kubantu Abane-IBD Eyaziwayo: Ukuhlolwa kusetshenziselwa nokuqapha iziguli esezitholakale zine-Crohn's noma i-colitis. Ukuhlola njalo amazinga e-calprotectin kusiza odokotela ukuthi bahlole ukuthi ukwelashwa kuyasebenza yini, ukuthi isifo siyaphela yini, noma ukuthi ukuqubuka kwesifo kuqala yini, ngezinye izikhathi ngisho nangaphambi kokuba izimpawu zivele.

Izinzuzo kanye nokulinganiselwa

Izinzuzo:
Akuhlaseli: Azikho izinaliti noma ama-scope adingekayo ekuhlolweni kokuqala.
Ithuluzi Eliwusizo Lokuhlinza: Lisiza ngempumelelo ukuhlukanisa ukuvuvukala nezimo ezingezona ezokuvuvukala, linciphisa isidingo sezinqubo ezingadingekile zokuhlasela njenge-colonoscopies yeziguli ze-IBS.
Kuhle Ekuqapheni: Kuhlinzeka ngesilinganiso esiqondile sokuvuvukala ngokuhamba kwesikhathi.

Imikhawulo:
Akucacisiwe: Kukhomba ukuvuvukala kodwa akubonisi imbangela noma indawo yakho ngqo.
Kungaba Nemiphumela Engamanga: Amazinga aphezulu angabonakala ngokusetshenziswa kwe-NSAID, izifo ezithile zamathumbu, noma kubantu asebekhulile.
Kudingeka Ukulandelela: Umphumela ophezulu cishe njalo udinga uphenyo olwengeziwe, ngokuvamile ngezinqubo ze-endoscopic ezifana ne-colonoscopy ukuze kutholakale ukuxilongwa okubonakalayo kanye nokuthatha ama-biopsy.

Isiphetho

Ngamafuphi, ukuhlolwa kwe-calprotectin yendle kuyithuluzi eliwusizo nelinobungane nesiguli ku-gastroenterology yesimanje. Kusebenza njengesivivinyo sokuqala esiphumelelayo sokuthola ukuvuvukala kwamathumbu, okusiza ukuhlukanisa phakathi kwe-IBD ne-IBS kanye nokuqondisa izinqumo mayelana nesidingo sokuhlolwa okunamandla kakhulu. Uma ubhekene nezimpawu zokugaya ukudla eziqhubekayo, khuluma nodokotela wakho mayelana nokuthi ukuhlolwa kwe-calprotectin kungaba yini isinyathelo sokuqala esiwusizo ohambweni lwakho lokuxilonga.

Ukuhlolwa okusheshayo kwe-Baysen kungakunikezaukuhlolwa okusheshayo kwe-calprotectinikhithi uma unesidingo. Siyakwamukela ukuxhumana nathi uma unesithakazelo.