Isingeniso

Ekuxilongweni kwezokwelapha kwanamuhla, ukuxilonga okusheshayo nokunembile kokuvuvukala kanye nokutheleleka kubalulekile ekungeneleleni nasekulashweni kusenesikhathi.I-Serum Amyloid A (SAA) iyi-biomarker ebalulekile yokuvuvukala, ebonise ukubaluleka okubalulekile kwezokwelapha ezifweni ezithelelanayo, izifo zokuzivikela komzimba, kanye nokuqapha ngemva kokuhlinzwa eminyakeni yamuva. Uma kuqhathaniswa nezimpawu zokuvuvukala zendabuko ezifana ne-Iphrotheni e-C-reactive (CRP), I-SAAinozwela oluphezulu kanye nokucacile, ikakhulukazi ekuhlukaniseni phakathi kokutheleleka ngamagciwane kanye namagciwane.

Ngokuthuthuka kwezobuchwepheshe bezokwelapha, I-SAAKuvele ukutholwa okusheshayo, okunciphisa kakhulu isikhathi sokutholwa, Kuthuthukisa ukusebenza kahle kokuxilonga, futhi kunikeze odokotela neziguli indlela yokuthola elula nethembekile. Lesi sihloko sixoxa ngezici zezinto eziphilayo, ukusetshenziswa kwemitholampilo kanye nezinzuzo zokutholwa okusheshayo kwe-SAA, ukusiza ochwepheshe bezempilo kanye nomphakathi baqonde kangcono lobu buchwepheshe obusha.

KuyiniI-SAA?

I-Serum Amyloid A (SAA)minaiyiprotheni yesigaba esibukhali eyenziwe yisibindi futhi iyingxenye yomndeni wama-apolipoprotein. Kubantu abaphilile,I-SAAamazinga ngokuvamile aphansi (<10 mg/L). Kodwa-ke, ngesikhathi sokuvuvukala, ukutheleleka, noma ukulimala kwezicubu, ukuhlushwa kwayo kungakhuphuka ngokushesha emahoreni ambalwa, ngezinye izikhathi kukhuphuke kuze kube yi-1000-fold.

Imisebenzi eyinhloko yeI-SAAfaka:

1. Ukulawulwa Kokuphendula Kwamasosha Omzimba: Kukhuthaza ukufuduka nokusebenza kwamaseli okuvuvukala futhi kuthuthukisa ikhono lomzimba lokususa amagciwane.
2. I-Lipid Metabolism: Ushintsho ezakhiweni kanye nokusebenza kwe-high-density lipoprotein (HDL) ngesikhathi sokuvuvukala.
3. Ukulungiswa kwezicubu: Kukhuthaza ukuvuselelwa kwezicubu ezonakele

Ngenxa yokusabela kwayo ngokushesha ekuvuvukeni, i-SAA iyi-biomarker efanelekile yokuxilongwa kokutheleleka kwasekuqaleni kanye nokuvuvukala.

I-SAAvs.I-CRP: Kungani kunjaloI-SAAOkungcono kakhulu?

NgesikhathiIphrotheni e-C-reactive (CRP)luphawu olusetshenziswa kabanzi lokuvuvukala,I-SAA ikwenza kudlule ngezindlela eziningana:

Izinzuzo Eziyinhloko ze-I-SAA

1. Ukutholwa Kwangaphambi Kwesikhathi:I-SAAamazinga akhuphuka ngokushesha ekuqaleni kanye nokutheleleka, okuvumela ukutholakala kusenesikhathi.
2. Ukuhlukanisa Izifo:
   • Ukutheleleka Kwamagciwane: KokubiliI-SAAfuthiI-CRPukwanda kakhulu.
   • Ukutheleleka Ngegciwane:I-SAAikhuphuka kakhulu, kuyilaphoI-CRP kungase kuhlale kujwayelekile noma kuphakame kancane.
3. Ukuqapha Umsebenzi Wezifo:I-SAAAmazinga ahlobene eduze nobunzima bokuvuvukala futhi ngenxa yalokho awusizo ezifweni zokuzivikela komzimba kanye nokuqapha ngemva kokuhlinzwa.

I-SAAUkuhlolwa Okusheshayo: Isixazululo Sezokwelapha Esisebenzayo Nesilula

YendabukoI-SAAUkuhlolwa kuncike ekuhlaziyweni kwamakhemikhali elabhorethri, okuvame ukuthatha amahora angu-1-2 ukuphothulwa.I-SAANgakolunye uhlangothi, ukuhlola kuthatha imizuzu eyi-15-30 kuphela ukuthola imiphumela, okuthuthukisa kakhulu ukusebenza kahle kokuxilonga.

Izici zeI-SAAUkuhlolwa Okusheshayo

1. Isimiso Sokuthola: Sisebenzisa i-immunochromatography noma i-chemiluminescence ukuze silinganiseI-SAAngama-antibodies athile.
2. Ukusebenza Okulula: kudingeka inani elincane legazi (igazi elinamathelayo noma elisemithambo yegazi), elifanele ukuhlolwa kwendawo yokunakekelwa (i-POCT).
3. Ukuzwela Okuphezulu Nokunemba: Umkhawulo wokuthola uphansi njengo-1 mg/L, ohlanganisa ububanzi obukhulu bezokwelapha.
4. Ukusebenza Okubanzi: Kufanelekela iminyango yezimo eziphuthumayo, izingane, ama-Intensive Care Units (ICU), imitholampilo yokunakekelwa okuyisisekelo, kanye nokuqapha impilo yasekhaya.

Izicelo Zemitholampilo zeI-SAAUkuhlolwa Okusheshayo

1. Ukuxilongwa Kwasekuqaleni Kwezifo
   • Umkhuhlane wezingane: Kusiza ukuhlukanisa ukutheleleka kwamagciwane namagciwane, kunciphisa ukusetshenziswa kwama-antibiotic okungadingekile.
   • Izifo zokuphefumula (isb., umkhuhlane, i-COVID-19): Ihlola ubukhali besifo.
2. Ukuqapha Ukutheleleka Ngemva Kokuhlinzwa
   • Ukuphakama okuqhubekayo kwe-SAA kungabonisa ukutheleleka ngemva kokuhlinzwa.
3. Ukuphathwa Kwezifo Ezizimele
   • Ilandelela ukuvuvukala kweziguli ezine-rheumatoid arthritis kanye ne-lupus.
4. Ingozi Yokutheleleka Okuhlobene Nomdlavuza Nokwelashwa Nge-Chemotherapy
   • Inikeza isixwayiso kusenesikhathi ezigulini ezinesifo sokuzivikela komzimba esibuthakathaka.

Amathrendi Esikhathi Esizayo kuI-SAAUkuhlolwa Okusheshayo

Ngokuthuthuka kwezokwelapha ngokunemba kanye ne-POCT, ukuhlolwa kwe-SAA kuzoqhubeka nokukhula:

1. Amaphaneli Amamaki Amaningi: I-S EhlanganisiweUkuhlolwa kwe-AA+CRP+PCT (procalcitonin) fnoma ukuxilongwa okunembile kakhulu kokutheleleka.
2. Amadivayisi Okuthola Okuhlakaniphile: Ukuhlaziywa okusebenzisa i-AI kokuhumusha kwesikhathi sangempela kanye nokuhlanganiswa kwezokwelapha ngocingo.
3. Ukuqapha Impilo Yasekhaya: OkuphathekayoI-SAAamadivayisi okuzihlola wona ukuze aphathe izifo ezingamahlalakhona.

Isiphetho esivela ku-Xiamen Baysen Medical

Ukuhlolwa okusheshayo kwe-SAA kuyithuluzi elinamandla lokuxilongwa kwasekuqaleni kokuvuvukala nokutheleleka. Ukuzwela kwayo okuphezulu, isikhathi sayo sokushintsha ngokushesha kanye nokulula kokusetshenziswa kwenza kube ithuluzi lokuhlola elibalulekile ekuqapheni okuphuthumayo, kwezingane kanye nangemuva kokuhlinzwa. Njengoba ubuchwepheshe buthuthuka, ukuhlolwa kwe-SAA kuzodlala indima enkulu ekulawuleni ukutheleleka, kwezokwelapha ezenzelwe wena kanye nempilo yomphakathi.

Thina i-baysene Medical sinayoIkhithi yokuhlola ye-SAA.Lapha sihlala sigxila kumasu okuxilonga ukuze sithuthukise ikhwalithi yokuphila.