I-Interleukin-6 iyi-polypeptide equkethe amaketanga amabili e-glycoprotein, anesisindo samangqamuzana angu-130kd. Njengelungu elibalulekile lenethiwekhi ye-cytokine, i-interleukin-6 (IL-6) idlala indima ebalulekile ekuphenduleni kokuvuvukala okunamandla, futhi ingaxhumanisa ukusabela kwesigaba esibucayi sesibindi, futhi ikhuthaze ukukhiqizwa kwe-C-reactive protein (CRP) ne-fibrinogen. Izifo eziningi ezithathelwanayo zingase ziholele ekukhuphukeni kwezinga le-serum IL-6, futhi izinga le-IL-6 lihlotshaniswa eduze nemiphumela yesiguli. Njenge-cytokine ye-pleiotropic esebenza kakhulu, i-IL-6 ikhiqizwa i-T cell, i-B cell, i-mononuclear phagocyte, ne-endothelial cell, futhi iyingxenye ebalulekile yenethiwekhi yomlamuli ovuthayo. Lapho kwenzeka ukusabela kokuvuvukala, i-IL-6's yakhiqiza kuqala, eyenza ukukhiqizwa kwe-CRP ne-procalcitonin (PCT) ekukhiqizeni kwayo. Izokhiqizwa ngokushesha uma kwenzeka ukutheleleka, ukulimala kwangaphakathi nangaphandle, ukuhlinzwa, ukusabela kokucindezeleka, ukufa kobuchopho, i-tumorigenesis, kanye nenqubo yokusabela kokuvuvukala okunamandla kwezinye izimo. I-IL-6 ihileleke ekuveleni nasekuthuthukisweni kwezifo eziningi, izinga layo legazi lihlobene eduze nokuvuvukala, ukutheleleka ngegciwane kanye nesifo sokuzivikela komzimba, futhi izinguquko zayo zenzeka ngaphambi kwe-CRP. Ngokwemiphumela yocwaningo, izinga le-IL-6 likhula ngokushesha ekuthelelekeni kwamagciwane, izinga le-PCT likhuphuka ngemva kwe-2h, kuyilapho i-CRP ikhula ngokushesha ngemva kwe-6h. Ukucasuka okungavamile noma ukubonakaliswa kofuzo kwe-IL-6 ngokuvamile kungaholela ekuveleni kochungechunge lwezifo, inani elikhulu le-IL-6 lingafihlwa ekujikelezeni kwegazi esimweni se-pathological, futhi ukutholakala kwe-IL-6 kubaluleke kakhulu ekuxilongweni kwesifo kanye nokwahlulela okubikezelwe.