Pepsinogen Iidityaniswe kwaye ifihliwe ngamaseli aphambili engingqi ye-oxyntic glandular yesisu, kwaye i-pepsinogen II idityaniswe kwaye igcinwe ngummandla we-pyloric wesisu. Zombini zenziwa zisebenze kwi-pepsins kwi-lumen yesisu yi-HCl ekhutshwe yi-fundic parietal cells.

1.Yintoni i-pepsinogen II?
I-Pepsinogen II yenye yeeprotheyini ezine ze-aspartic: i-PG I, i-PG II, i-Cathepsin E kunye ne-D. I-Pepsinogen II iveliswa ngokuyinhloko kwi-Oxyntic gland mucosa yesisu, i-antrum ye-gastric kunye ne-duodenum. Ifihliwe ikakhulu kwi-lumen yesisu kunye nokujikeleza.
2.Ngawaphi amacandelo e-pepsinogen?
I-Pepsinogens iqukethe ikhonkco elilodwa le-polypeptide kunye nobunzima be-molecular malunga ne-42,000 Da. I-Pepsinogens idityanisiwe kwaye ikhuselwe ngokuyintloko ziiseli eziphambili zesisu sesisu somntu ngaphambi kokuba ziguqulwe zibe yi-proteolytic enzyme pepsin, ebaluleke kakhulu kwiinkqubo zokwetyisa esiswini.
3.Nguwuphi umahluko phakathi kwe-pepsin kunye ne-pepsinogen?
I-Pepsin yi-enzayimi yesisu esebenza ekutyiseni iiproteni ezifumaneka ekutyeni okutyiweyo. Iiseli eziphambili zesisu zikhupha i-pepsin njenge-zymogen engasebenziyo ebizwa ngokuba yi-pepsinogen. Iiseli zeParietal ngaphakathi komgca wesisu zikhupha i-hydrochloric acid eyehlisa i-pH yesisu.

Ikhithi yokuxilonga ye-Pepsinogen I/ PepsinogenII (i-Fluorescence Immuno Assay)luvavanyo lwe-fluorescence immunochromatographic yokufumanisa ubungakanani be-PGI/PGII kwi-serum yabantu okanye iplasma, Isetyenziswa ikakhulu ukuhlola ukusebenza kweseli ye-oxyntic ye-gastric kunye ne-gastric fundus mucinous isifo kwiklinikhi.

Wamkelekile kuqhagamshelwano ngeenkcukacha ezithe vetshe.