USHWANKATHELO

Njengeprotein yesigaba esibukhali, i-serum amyloid A iyeye-heterogeneous protein ye-apolipoprotein yosapho, ethi
inobunzima bemolekyuli obumalunga. 12000. Iicytokines ezininzi zibandakanyeka kulawulo lwentetho ye-SAA
kwimpendulo yenqanaba elibukhali. Ukukhuthazwa yi-interleukin-1 (IL-1), i-interleukin-6 (IL-6) kunye ne-tumor necrosis factor-α
(TNF-α), i-SAA yenziwe yi-macrophages esebenzayo kunye ne-fibroblast esibindi, enesiqingatha sobomi obufutshane kuphela.
malunga nemizuzu engama-50. Iibhondi ze-SAA ezine-high-density lipoprotein (HDL) egazini ngokukhawuleza ekudityanisweni kwesibindi,
idinga ukuthotywa yi-serum, i-cell surface kunye ne-intracellular proteases. Kwimeko ethile ebukhali kwaye engapheliyo
ukudumba okanye usulelo, izinga lokuthotywa kwe-SAA emzimbeni ngokucacileyo liyehla ngelixa i-synthesis isanda,
nto leyo ekhokelela ekunyukeni okuqhubekayo koxinaniso lwe-SAA egazini. I-SAA yiprotheyini yesigaba esibukhali kunye nokudumba
isiphawuli esenziwe ngehepatocytes. Ukuxinana kwe-SAA egazini kuya kunyuka kwiiyure ezimbalwa emva koko
ukwenzeka kokudumba, kwaye ukugxininiswa kwe-SAA kuya kuba namaxesha angama-1000 okunyuka ngexesha elibukhali
ukudumba. Ngoko ke, i-SAA ingasetyenziselwa njengesalathisi sosulelo lwe-microbial okanye ukuvuvukala okuhlukeneyo, oku
inokuququzelela ukuxilongwa kokuvuvukala kunye nokubeka iliso kwimisebenzi yonyango.

Ikhithi yethu yokuxilonga yeSerum Amyloid A (i-Fluorescence Immunochromatographic Assay) iyasebenza kwi-vitro yokufumanisa ubungakanani bomzimba kwi-serum amyloid A (SAA) kwiserum yabantu/iplasma/isampuli yegazi lonke, kwaye isetyenziselwa ukuxilongwa okuncedisayo kokudumba okubukhali nokungapheliyo okanye usulelo.

Wamkelekile kuqhagamshelwano ngeenkcukacha ezithe vetshe ukuba unomdla.