I-Sepsis yaziwa ngokuba "ngumbulali othuleyo". Isenokuba ayiqhelekanga kubantu abaninzi, kodwa eneneni ayikude kuthi. Ngoyena nobangela wokufa ngenxa yosulelo kwihlabathi liphela. Njengesigulo esiyingozi, Izinga lokugula kunye nokufa kwe-sepsis kuhlala kuphezulu. Kuqikelelwa ukuba kukho malunga ne-20 ukuya kwi-30 yezigidi zeemeko ze-sepsis emhlabeni wonke minyaka le, kwaye umntu omnye uphulukana nobomi bakhe phantse rhoqo kwimizuzwana emi-3 ukuya kwe-4.

Ekubeni izinga lokufa kwe-sepsis linyuka ngeeyure, ixesha liyindongo kunyango lwe-sepsis, kwaye ukuchongwa kwangaphambili kwe-sepsis kuye kwaba yinto ebaluleke kakhulu yonyango. Kwiminyaka yakutshanje, i-heparin-binding protein (HBP) ibonakaliswe njengenye yamanqaku avelayo okuxilongwa kwangaphambili kwentsholongwane yebhaktheriya, inceda oogqirha ukuba babone izigulane ze-sepsis ngokukhawuleza kunye nokuphucula iziphumo zonyango.

• Ukuchongwa kweBhaktheriya kunye neNtsholongwane

Ngenxa yokuba i-HBP iqala ukukhutshwa kwinqanaba lokuqala losulelo lwebhaktheriya, ukufunyanwa kwe-HBP kunokubonelela ngobungqina bonyango lweklinikhi kwangethuba, ngaloo ndlela kuncitshiswe ukusuleleka kwentsholongwane yebhaktheriya kunye ne-sepsis. Ukufunyanwa okudityanisiweyo kwe-HBP kunye namanqaku okuvuvukala asetyenziswa ngokuqhelekileyo kunokuphucula ukuchaneka kokuxilonga.

• Uvavanyo lobungqongqo bosulelo HBP

Ugxininiso lunxulunyaniswa ngokuqinisekileyo nobungqongqo bosulelo kwaye lunokusetyenziswa ukuvavanya ubungqongqo bosulelo.

• Isikhokelo malunga nokusetyenziswa kweziyobisi

I-HBP inokubangela ukuvuza kwe-vascular kunye ne-tissue edema. Njengonobangela, yinto ekujoliswe kuyo kumachiza afana ne-heparin kunye ne-albumin ukunyanga ukungasebenzi kakuhle kwamalungu. Iziyobisi ezifana ne-albumin, i-heparin, i-hormone, i-simvastatin, i-tizosentan, kunye ne-dextran sulfate inokunciphisa ngokufanelekileyo izinga le-plasma ye-HBP kwizigulane.

Uvavanyo lwe-baysenrapid sineemveliso ezininzi ezinokusetyenziselwa ukuxilongwa kwangaphambili kwe-HBP ezifanaCRP/SAA/PCT ikhithi yovavanyo olukhawulezayo.Wamkelekile ukuba uqhagamshelane ngeenkcukacha ezithe vetshe.