I-Mycoplasma pneumoniae yimbangela eqhelekileyo yosulelo lwendlela yokuphefumla, ngakumbi kubantwana kunye nabantu abadala. Ngokungafaniyo neentsholongwane zebhaktiriya eziqhelekileyo, i-M. pneumoniae ayinaludonga lweseli, iyenza ibe yodwa kwaye isoloko inzima ukuyixilonga. Enye yezona ndlela zisebenzayo zokuchonga usulelo olubangelwa yile bhaktiriya kukuvavanya izilwa-buhlungu ze-IgM.

Izilwa-buhlungu ze-IgM zizikhuseli zokuqala eziveliswa yi-immune system ukuphendula usulelo. Xa umntu osulelwe yiMycoplasma pneumoniae, umzimba uqala ukuvelisa izilwa-buhlungu ze-IgM kwisithuba seveki okanye ezimbini. Ubukho bezi zithinteli-mzimba bunokuba luphawu olubalulekileyo losulelo olusebenzayo kuba zimele impendulo yokuqala yomzimba.

Ukuvavanyelwa izilwa-buhlungu ze-IgM ukuya kwi-M. pneumoniae ngokuqhelekileyo kwenziwa ngovavanyo lwe-serological. Olu vavanyo lunceda ukwahlula usulelo lwe-M. pneumoniae kwezinye iintsholongwane zokuphefumla, ezifana neentsholongwane okanye iibhaktheriya eziqhelekileyo ezifana neStreptococcus pneumoniae. Uvavanyo oluqinisekileyo lwe-IgM lunokuxhasa ukufunyaniswa kwenyumoniya engaqhelekanga, edla ngokubonakala ngokuqala kancinci kweempawu, kubandakanya ukukhohlela okuzingileyo, umkhuhlane, kunye nokungalungi.

Nangona kunjalo, iziphumo ze-antibody ze-IgM kufuneka zitolikwe ngononophelo. Iimpawu zobuxoki zingenzeka, kwaye ixesha lovavanyo libalulekile. Ukuvavanywa kwangethuba kakhulu kunokuvelisa iziphumo ezingalunganga kuba izilwa-buhlungu ze-IgM zithatha ixesha ukuphuhla. Ke ngoko, oogqirha badla ngokuqwalasela imbali yesigulana kunye neempawu kunye neziphumo zaselabhoratri ukwenza uxilongo oluchanekileyo.

Ukuqukumbela, ukuvavanyelwa izilwa-buhlungu ze-M. pneumoniae IgM kudlala indima ebalulekileyo ekuxilongeni usulelo lokuphefumla. Ukuqonda le mpendulo ye-immune inokunceda ababoneleli bezempilo banikeze unyango olufike ngexesha kunye nolufanelekileyo, ekugqibeleni luphucule iziphumo zesigulane. Njengoko uphando luqhubeka, sinokufumanisa ngakumbi ngendima edlalwa zezi zilwa-buhlungu ekulweni izifo zokuphefumla.