Ferritin: I-Biomarker ekhawulezayo kunye nechanekileyo yokuHlola ukusilela kwe-Iron kunye ne-Anemia

Intshayelelo

Ukunqongophala kwe-iron kunye ne-anemia ziingxaki zempilo eziqhelekileyo kwihlabathi jikelele, ngakumbi kumazwe asakhasayo, abafazi abakhulelweyo, abantwana kunye nabasetyhini abakwiminyaka yokuzala. I-Iron Deficiency anemia (IDA) ayichaphazeli nje kuphela umsebenzi womzimba kunye nokuqonda komntu ngamnye, kodwa inokunyusa umngcipheko weengxaki zokukhulelwa kunye nokulibaziseka kokuphuhliswa kwabantwana. Ngoko ke, ukuhlolwa kwangaphambili kunye nokungenelela kubalulekile. Phakathi kwezalathi ezininzi zokufumanisa, i-ferritin ibe sisixhobo esibalulekileyo sokuhlola ukunqongophala kwentsimbi kunye ne-anemia ngenxa yobuthathaka obuphezulu kunye neenkcukacha. Eli nqaku liza kuxubusha iimpawu zebhayoloji ye-ferritin, iingenelo zayo ekuxilongeni ukusilela kwesinyithi kunye ne-anemia, kunye nexabiso lesicelo seklinikhi.

Iimpawu zebhayoloji zeFerritin

Ferritinyiprotheni yokugcina isinyithi ekhoyo ngokubanzi kwiithishu zomntu. Ikakhulu yenziwa sisibindi, udaka kunye nomongo wethambo. Umsebenzi wayo ophambili kukugcina isinyithi kunye nokulawula ukulingana kwe-metabolism yensimbi. Egazini, ukuxinana kweferritininxibelelene kakuhle noovimba bentsimbi bomzimba. Ngoko ke, serumferritinamanqanaba sesinye sezona zalathisi ezinovakalelo zesimo sogcino lwentsimbi yomzimba. Ngaphantsi kweemeko eziqhelekileyo, inqanaba le-ferritin kumadoda akhulileyo malunga ne-30-400 ng / mL, kwaye kwabasetyhini i-15-150 ng / mL, kodwa kwimeko yokusilela kwesinyithi, eli xabiso liya kuncitshiswa kakhulu.

Izinto ezilungileyo zeFerritinkuHlolo lokunqongophala kwentsimbi

1. Uvakalelo oluphezulu, ukufumanisa kwangaphambili ukusilela kwentsimbi

Ukukhula kokunqongophala kwentsimbi kwahlulwe ngokwezigaba ezithathu:

• Inqanaba lokunqongophala kwentsimbi: intsimbi yokugcina(i-ferritin) iyancipha, kodwa i-hemoglobin iyinto eqhelekileyo;
• Ukunqongophala kwe-iron isigaba se-erythropoiesis:ferritiniyancipha ngakumbi, i-transferrin saturation iyancipha;
• Inqanaba lokusilela kwe-iron anemia: i-hemoglobin iyancipha, kwaye iimpawu ze-anemia zivela.

Iindlela zokuhlola eziqhelekileyo (ezifana novavanyo lwe-hemoglobin) ziyakwazi ukubona iingxaki kuphela kwinqanaba le-anemia, ngelixaferritinuvavanyo lunokubona izinto ezingaqhelekanga kwisigaba sokuqala sokunqongophala kwentsimbi, ngaloo ndlela inika ithuba lokungenelela kwangoko.

2. Ukuchaneka okuphezulu, Ukunciphisa i-Misdiagnosis

Izifo ezininzi (ezifana nokudumba okungapheliyo kunye nokusuleleka) zinokubangela i-anemia, kodwa azibangelwa kukunqongophala kwentsimbi. Kule meko, ukuthembela kuphela kwi-hemoglobin okanye i-meat corpuscular volume (MCV) inokungaqondi kakuhle isizathu.Ferritinuvavanyo lunokwahlula ngokuchanekileyo i-anemia yokusilela kwesinyithi kwezinye iintlobo ze-anemia (ezifana ne-anemia yesifo esingapheliyo), ukuphucula ukuchaneka kokuxilonga.

3. Ukukhawuleza kunye nokufanelekileyo, ukulungele ukukhangela ubungakanani obukhulu

Itekhnoloji yanamhlanje yovavanyo lwe-biochemical yenza ukuzimisela kwe-ferritin ngokukhawuleza kwaye kuqoqosho ngakumbi, kwaye ilungele iiprojekthi zempilo yoluntu ezifana novavanyo loluntu, ukhathalelo lwempilo kamama kunye nosana, kunye nokujongwa kwesondlo somntwana. Xa kuthelekiswa neemvavanyo ezihlaselayo ezifana ne-bone marrow staining yentsimbi (umgangatho wegolide), uvavanyo lwe-serum ferritin kulula ukukhuthaza.

Izicelo zeklinikhi zeFerritin kuLawulo lwe-Anemia

1. Isikhokelo sonyango lwe-iron supplementation

Ferritinamanqanaba anokunceda oogqirha baqonde ukuba ngaba izigulane zidinga i-iron supplementation kunye nokubeka iliso ekusebenzeni kwonyango. Umzekelo:

• Ferritin<30 ng/mL: ibonisa ukuba i-iron reserve iyancipha kwaye i-iron supplementation iyadingeka;
• Ferritin<15 ng/mL: ibonisa kakhulu ukusilela kwe-anemia yensimbi;
• Xa unyango lusebenza, ferritin amanqanaba aya kunyuka ngokuthe ngcembe kwaye angasetyenziselwa ukuvavanya ukusebenza kakuhle

1. I-Iron eSikhokelo soFakelo

Ferritinamanqanaba anceda oogqirha ukuba babone isidingo sonyango lwentsimbi kunye nokubeka iliso ekusebenzeni konyango. Umzekelo:

• Ferritin<30 ng/mL: Ibonisa iivenkile zentsimbi eziphelelweyo, ezifuna ukongezwa.
• Ferritin<15 ng/mL: Icebisa kakhulu i-anemia yokusilela kwesinyithi.
• Ngexesha lokunyanga, ukunyukaferritinamanqanaba aqinisekisa ukusebenza konyango.

2. Ukuhlolwa kwabantu abakhethekileyo

• Abasetyhini abakhulelweyo: imfuno yentsimbi iyanda ngexesha lokukhulelwa, kunyeferritinUvavanyo lunokuthintela iingxaki zoomama kunye neentsana.
• Abantwana: Ukunqongophala kwentsimbi kuchaphazela ukukhula kwengqondo, kwaye ukuhlolwa kwangaphambili kunokuphucula i-prognosis.
• Izigulana ezinezifo ezinganyangekiyo: njengezigulana ezinesifo sezintso kunye nesifo sokukrala kwamathumbu,ferritin kudityaniswe ne-transferrin saturation inokuchonga uhlobo lwe-anemia.

Unyino lweFerritinUvavanyo kunye nezisombululo

Nangona i-ferritin isalathiso esikhethiweyo sokuhlolwa kokusilela kwentsimbi, kufuneka itolikwe ngononophelo kwezinye iimeko:

• Ukudumba okanye usulelo:Ferritin, njengeprotheni ye-acute phase reactant, inokuthi iphakanyiswe ngobuxoki kwintsholongwane, i-tumor okanye ukuvuvukala okungapheliyo. Kule meko, inokudibaniswa kunyeIprotheyini esebenzayo (CRP) ortransferrinukuhluza kumgwebo obanzi.
• Isifo sesibindi:Ferritinkwizigulane ezine-cirrhosis zinokunyuka ngenxa yokulimala kweeseli zesibindi kwaye kufuneka zihlolwe ngokudibanisa nezinye izikhombisi ze-iron metabolism.

Ukuqukumbela

Ferritinuvavanyo lube sisixhobo esibalulekileyo sokuhlola ukunqongophala kwentsimbi kunye ne-anemia ngenxa yobuntununtunu obuphezulu, ukuchaneka kunye nokulula. Ayinakubona kuphela ukunqongophala kwentsimbi kwangoko kwaye igweme ukuqhubela phambili kwe-anemia, kodwa iphinda ikhokele unyango oluchanekileyo kunye nokuphucula i-prognosis yesigulane. Kwimpilo yoluntu kunye nokusebenza kweklinikhi, ukukhuthazwa kweferritin uvavanyo lunokunceda ukunciphisa umthwalo wesifo se-anemia yokusilela kwesinyithi, ngakumbi kumaqela asemngciphekweni omkhulu (njengabafazi abakhulelweyo, abantwana kunye nezigulane ezinezifo ezingapheliyo). Kwixesha elizayo, ngenkqubela phambili yetekhnoloji yokufumanisa,ferritin inokudlala indima enkulu kuthintelo nakulawulo lwe-anemia.

Thina iBaysen Medical sihlala sigxile kwindlela yokuxilonga ukuphucula umgangatho wobomi. Siphuhlise amaqonga etekhnoloji ama-5- iLatex, igolide ye-colloidal, iFluorescence Immunochromatographic Assay, iMolekyuli, iChemiluminescence Immunoassay, eyethu.Ikhithi yovavanyo yeFerritin umsebenzi olula kwaye unokufumana iziphumo zovavanyo kwimizuzu eyi-15