C-peptide, okanye ukudibanisa i-peptide, yi-short-chain amino acid edlala indima ebalulekileyo ekuveliseni i-insulin emzimbeni. Yimveliso yemveliso ye-insulin kwaye ikhutshwa yi-pancreas ngezixa ezilinganayo kwi-insulin. Ukuqonda i-C-peptide kunokubonelela ngolwazi oluxabisekileyo kwiimeko ezahlukeneyo zempilo, ngakumbi isifo seswekile.

Xa i-pancreas ivelisa i-insulin, ekuqaleni ivelisa i-molecule enkulu ebizwa ngokuba yiproinsulin. Iproinsulin ke ngoko yohlulwa ibe ngamacandelo amabini: insulin kunye neC-peptide. Ngelixa i-insulin inceda ukulawula amanqanaba eswekile yegazi ngokukhuthaza ukunyuswa kweglucose kwiiseli, i-C-peptide ayinayo indima ngqo kwimetabolism yeglucose. Nangona kunjalo, luphawu olubalulekileyo lokuvavanya umsebenzi we-pancreatic.

Olunye lolona setyenziso luphambili lokulinganisa amanqanaba e-C-peptide kukuxilonga nokulawula isifo seswekile. Kubantu abanesifo seswekile sohlobo loku-1, amajoni omzimba ahlasela kwaye atshabalalise iiseli ze-beta ezivelisa i-insulin kwi-pancreas, okukhokelela kumanqanaba asezantsi okanye angabonakaliyo e-insulin kunye ne-C-peptide. Ngokwahlukileyo, abantu abanesifo sikashukela sohlobo lwe-2 bahlala benamanqanaba aqhelekileyo okanye aphakamileyo e-C-peptide ngenxa yokuba imizimba yabo ivelisa i-insulin kodwa iyaxhathisa kwimiphumo yayo.

Imilinganiselo ye-C-peptide inokunceda kwakhona ukwahlula phakathi kohlobo lwe-1 kunye nohlobo lwe-2 yeswekile, isikhokelo kwizigqibo zonyango, kunye nokubeka iliso ekusebenzeni kwonyango. Umzekelo, isigulana esinesifo seswekile sohlobo loku-1 esenza i-islet cell transplant sinokuthi amanqanaba e-C-peptide abekwe esweni ukuvavanya impumelelo yenkqubo.

Ukongeza kwisifo sikashukela, i-C-peptide ifundwe ngeziphumo zayo ezikhuselayo kwiintlobo ezahlukeneyo zezicubu. Olunye uphando lubonisa ukuba i-C-peptide inokuba neepropati ezichasayo ezinokuthi zincede ukunciphisa iingxaki ezinxulumene nesifo seswekile, ezifana nomonakalo we-nerve kunye nezintso.

Ekugqibeleni, nangona i-C-peptide ngokwayo ayichaphazeli ngokuthe ngqo amanqanaba e-glucose yegazi, i-biomarker ebalulekileyo yokuqonda nokulawula isifo sikashukela. Ngokulinganisa amanqanaba e-C-peptide, ababoneleli bezempilo banokufumana ingqiqo malunga nomsebenzi we-pancreatic, bahlule phakathi kweentlobo zesifo sikashukela, kunye nezicwangciso zonyango lokulungelelanisa iimfuno zomntu ngamnye.

Sinayo iBaysen MedicalIkhithi yovavanyo lwe-C-peptide ,Ikhithi yovavanyo lwe-insulinkwayeIkhithi yovavanyo lwe-HbA1Cngenxa yesifo seswekile