I-Interleukin-6 i-polypeptide equlethwe ngamakhonkco amabini e-glycoprotein, enobunzima be-molecular 130kd. Njengelungu elibalulekileyo lenethiwekhi ye-cytokine, i-interleukin-6 (IL-6) idlala indima ephambili kwi-acute inflammatory reaction, kwaye inokudibanisa ukusabela kwesigaba esibuhlungu sesibindi, kunye nokukhuthaza ukuveliswa kweprotheni ye-C-reactive (CRP) kunye ne-fibrinogen. Izifo ezininzi ezithathelwanayo zingakhokelela ekunyukeni kwinqanaba le-serum IL-6, kunye nenqanaba le-IL-6 lihambelana ngokusondeleyo neziphumo zesigulane. Njenge-cytokine ye-pleiotropic enemisebenzi ebanzi, i-IL-6 ifihliwe yi-T cell, i-B cell, i-phagocyte ye-mononuclear, kunye ne-endothelial cell, kwaye iyinxalenye ephambili yenethiwekhi yomlamli ovuthayo. Xa kwenzeka ukusabela okuvuthayo, i-IL-6 yavelisa okokuqala, eyenza ukuveliswa kwe-CRP kunye ne-procalcitonin (PCT) kwimveliso yayo. Iza kuveliswa ngokukhawuleza kwimeko yosulelo, ukwenzakala kwangaphakathi nangaphandle, utyando, ukusabela koxinzelelo, ukufa kwengqondo, i-tumorigenesis, kunye nenkqubo yokusabela ebukhali kwezinye iimeko. I-IL-6 ibandakanyeka kwisehlo kunye nokuphuhliswa kwezifo ezininzi, inqanaba legazi layo lihambelana ngokusondeleyo nokuvuvukala, ukusuleleka kwintsholongwane kunye nesifo esizimele, kwaye utshintsho lwalo lwenzeka kwangaphambili kune-CRP. Ngokweziphumo zophando, inqanaba le-IL-6 landa ngokukhawuleza kwintsholongwane yebhaktheriya, inqanaba le-PCT landa emva kwe-2h, ngelixa i-CRP inyuka ngokukhawuleza emva kwe-6h. Ukukhutshwa okungaqhelekanga okanye ukubonakaliswa kofuzo lwe-IL-6 kaninzi kunokukhokelela ekuveleni koluhlu lwezifo, isixa esikhulu se-IL-6 sinokufihlwa kwi-blood circulation kwi-pathological state, kwaye ukufumanisa i-IL-6 kubaluleke kakhulu ekuxilongweni kwesifo kunye nesigwebo se-prognostic.