Kansarka mindhicirka

Kansarka mindhicirka (CRC, oo ay kujirto kansarka malawadka iyo kansarka xiidanka) waa mid ka mid ah burooyinka caanka ah ee majaajillada caloosha.

Kansarka caloosha ee Shiinaha ayaa noqday "dilaaga ugu horeeya ee Shiinaha", qiyaastii 50% bukaannada kansarka caloosha ee caloosha ayaa ka dhaca Shiinaha, iyo 60% dhexe iyo soo daahay.

Iyadoo aan loo eegin kiiska cusub ama dhimashada, wadarta tirada kansarka caloosha ee caloosha ayaa ka sarreeyay kansarka sanbabada. Dhibaatada xiidmaha ayaa si fudud looga bogsadaa dhammaan kansarrada illaa baarista hore. Waa basasha ugu horreysa ee bini-aadamka si looga adkaado kansarka. Kaliya 5% kansarka luuqadaha Shiinaha ee Shiinaha ayaa goor hore lagu ogaaday, iyo 60-70% bukaannada qaba kansarka mindhicirka ayaa laga helay inay leeyihiin qanjidhada ama metastases fog. Heerka soo noqnoqda wuxuu ahaa mid ka sarreeya 30%.

Japan iyo Kuuriyada Koonfureed sidoo kale waa wadamada ay ku jiraan dhacdo sare oo ah kansarka caloosha, laakiin heerka ogaanshaha hore waa 50-60%, in kabadan 90% bukaannada waa la daaweyn karaa. Daraasad gudaha ah iyo caalami ah ayaa muujisay in tallaabooyinka baarista kansarka ee mindhicirka uu yareyn karo dhacdada iyo geerida kansarka mindhicirka.

Sanadihii la soo dhaafay, ka sokow Yurub, waqooyiga Ameerika, Japan, Singapore, South Korea, Taiwan, Taiwan, iyo Hong Kong, waxaa jiray baaritaanno qaran oo ay dowlad-wadeen. Baadhitaanka hore ee baaritaanka cudurka kansarka caloosha ee caloosha ayaa leh fursad in si buuxda loogu daaweeyo, oo leh muhiimad bulsho oo weyn iyo qiimo suuqa.

Dhacdada kansarka mindhicirka waa hanaan aad u dheer. Laga soo bilaabo burooyinka si aan caadi ahayn oo loo yaqaan 'hyperplasia' oo aan caadi ahayn oo loo geysto kansarka, waxay qaadataa waqti dheer, kaas oo bixiya waqti baaritaanka kansarka mindhicirka. Daaweynta wax ka qabashada hore iyo ka-hortagga hore waxay yareyn kartaa dhacdada kansarka 60% iyo heerka dhimashada ee 80%.

2, Muhiimadda Calprotectin ee Imtixaanka Hawsha xiidmaha

Calprotectin waa borotiin kaalshiyam-zinc-zinc-zinc-ka ah oo laga soo qaatay neutrophils iyo macrophil, oo leh miisaanka molicular ee 36,000, oo ah heterodimer oo ay sameeyeen isu-imaatinka silsiladda laba silsilad ah ee Mrp14 iyo hal silsilad ah MRP8, oo ka tirsan S100. Borotiinka qoyska.

Iyada oo loo marayo suugaanta cilmi-baarista ballaaran iyo xaqiijinta rugta caafimaad, Calprotectin waxay leedahay dareen xasaasi ah oo lagu ogaanayo kansarka mindhicirka mana saameyn ku yeelato marxaladda burooyinka, kaas oo laga heli karo xilliga hore iyo asymptomatic. Waxaa loo isticmaali karaa calaamad ahaan baarista kansarka kansarka mindhicirka.

Dareenka xumaynta dareenka saqafka xun, tijaabada dhiigga ee saxarada iyo serum Cea ee kansarka mindhicirka wuxuu ahaa 88.51%, 83.91% iyo 44.83%, siday u kala horreeyaan. Heerka togan ee tijaabada dhiigga ee saxarada iyo serum Cea ee bukaanka qaba marxaladda D iyo marxaladda ay si aad ah uga hooseyso taas oo ah farqi weyn oo ku saabsan heerka wanaagsan ee loo yaqaan 'Fecal Calprotcin' Dukes.

Cudurka ogaanshaha cudurka 'FECALEN CalSprotectin ogaanshaha cudurka kansarka malawadka ahi wuxuu gaadhay 92.7%, iyo qiimaha saadaalinta xun ee NPV ay gaartay 98.6%. Feela Calprotectin kansarka mindhicirka, ≥10mm prolyps polyps qiimaha saadaalinta xun ee NPV wuxuu gaadhay 97.2%.

Up to now, more than 20 countries such as the United States, Britain, Canada, France, Germany, and Switzerland have used calprotectin as an important indicator for screening inflammatory bowel disease and cancer in high-risk populations of intestinal diseases, and evaluated inflammatory cudurka mindhicirka. Firfircoonaanta iyo bogsashada calaamadaha muhiimka ah ayaa si balaadhan loogu adeegsadaa waxqabadka rugta caafimaad.

3, Faa'iidooyinka dhiiga caleenta ah ee la isku daro ee la isku daro oo ah qiimeynta halista kaadida ee calool-tallaabada cudurka kansarka

1. Way fududahay in la shaqeeyo: Hal muunad, natiijooyin badan oo tijaabo ah
2. Ma kordhiso dhibaatada hawsha iyo qiimaha aaladda: Qalabka ayaa la dhigayaa, qalabkana waxaa loo qalabeeyay iyadoo loo eegayo shuruudaha.
3. Dareenka xasaasiga ah iyo cayilka: tusaalaha bararka, dhiig-ka-dhiig-baxa caloosha
4. Horusocodka Mar hore ee Isgaarsiinta: Kordhinta itimaalka baaritaanka ee Adenocarcinoma iyo Proyps
5. Qiimaha ogaanshaha hoose, waxaa loo isticmaali karaa in dheecaanka colonoscopy-ga
6. Joojinta: Baadhitaanka Dufcadda Sanadka

Calaamadaha caadiga ah ee kansarka mindhicirka:

Kulanka xiidmaha - Calprotectin, Dukes marxaladda waa bukaanka A iyo B ee ah sicir bararka sicir-bararka iyo heerka heerarka ee kaladuwan ee bukaanka, heerka wanaagsan ee bukaanka, heerka togan ee xudunta xudunta.

Dhiigbax caloosha ah - dhiig sixir, wareejin. Dhiig-baxa dhiig-baxa caloosha waxaa loola jeedaa luminta dhiigga iyada oo loo marayo marinka caloosha ee sababao kala duwan awgood. Sababaha caamka ah waxaa ka mid ah bararka dheef-shiidka ee isku-dheef-shiidka laftiisa, waxyeelada makaanikada, cudurka xididdada, burada, iyo cudurrada muuqaalka vastroner-ka. Tijaabada unugyada 'sixir' waa nidaam joogto ah oo muhiim ah oo lagu ogaado dhiig-ka-dhiigbarka caloosha.

4, Habka loo ogaanayo Fecal Calprotcinectkin

Qalabkayaga tijaabada ee Calprottin (Qaabka Dahabka Dahabka ah) ayaa loo isticmaali karaa kaligiis ilaa semi-koob lagu ogaado Calprotectin ee saamballada saxarada ee saxarada. Waxaa sidoo kale loo isticmaali karaa taxanaha Wiz ee isdaba-joogga ah ee Impanossays.

Qalabka 'Calprotcin' (ImmErescescectopratogratogratogratogratogratogratogratograloon) wuxuu ku gaari karaa ogaanshaha tiro, qiyamka tirooyinka saxda ah, iyo kala duwanaanta toosan, si loo gaaro saameynta cudurada camalka.

Qalabka tijaabada dhiigga ee sixirka (Qaabka Dahabka Dahabka) waxaa loo isticmaalaa ogaanshaha tayada ee haemoglobin bini aadamka ee saxarada aadanaha, kaasoo ku habboon ogaanshaha dhiig-baxa caloosha.