Colorectal cancer

Colorectal cancer (CRC, inosanganisira rectal cancer uye colon cancer) ndeimwe yeakajairika mamota akashata emudumbu turakiti.

Gomarara remudumbu reChina rave "muurayi wekutanga wenyika", angangoita makumi mashanu muzana evarwere vegomarara remudumbu anoitika muChina, uye 60% yepakati nepakati.

Pasinei nenyaya itsva kana kufa, huwandu hwekenza dzemudumbu hwakapfuura kenza yemapapu. Gomarara remudumbu ndiro rinorapika zviri nyore pagomarara rose kuburikidza nekukasika kuvhenekwa. Ndiyo nhare yekutanga yevanhu kukunda gomarara. Chete 5% yeChinese colorectal cancers yakaonekwa nekukurumidza, uye 60-70% yevarwere vane colorectal cancer vakawanikwa vaine lymph nodes kana kure metastases. Chiyero chekudzokorora chaive chakakwira se30%.

Japan neSouth Korea inyika zvakare dzine chirwere chegomarara remudumbu chakanyanya, asi kukurumidza kuvhenekwa kwadzo i50-60%, uye vanopfuura 90% yevarwere vanogona kurapwa. Tsvagiridzo yemumba neyekunze inoratidza kuti colorectal cancer yekuongorora matanho anogona kuderedza kuitika uye kufa kwegomarara re colorectal.

Mumakore achangobva kupfuura aya, mukuwedzera kuEurope, North America, Japan, Singapore, South Korea, Taiwan, uye Hong Kong, kwave kune kuongorora kukuru kwenyika kunotungamirirwa nehurumende. Kuongororwa kwekutanga kwechirwere chegomarara remudumbu kune mukana wekupora zvachose, nekukosha kukuru kwemagariro uye kukosha kwemusika.

Kuitika kwegomarara remukati chiitiko chakareba. Kubva pamapolyps kusvika kune abnormal hyperplasia kuenda kugomarara, kazhinji zvinotora nguva yakareba, izvo zvinopa nguva yekuongororwa kwegomarara remukati. Kubudirira kwekutanga kuongororwa uye kupindira kurapwa kunogona kuderedza chiitiko chegomarara ne60% uye huwandu hwevanhu vanofa ne80%.

2, Kukosha kwecalprotectin mu intestinal basa kuongorora

Calprotectin inonzi calcium-zinc-binding protein yakabva kune neutrophils uye macrophages, ine molecular uremu hwe36,000, heterodimer yakaumbwa nesangano risingaiti-covalent remaketani maviri anorema MRP14 uye imwe ketani yechiedza MRP8, yeS100. Mapuroteni emhuri.

Kuburikidza nekuwanda kwemabhuku ekutsvagisa uye kuongororwa kwekiriniki, calprotectin ine yakanyanya kunzwa yekuona colorectal cancer uye haina kukanganiswa nebundu nhanho, iyo inogona kuwanikwa munguva yekutanga uye asymptomatic. Inogona kushandiswa sechiratidzo chekuongorora cancer cancer.

Kunzwa kwefecal calprotectin, fecal occult blood test uye serum CEA yecancer colorectal yaive 88.51%, 83.91% uye 44.83%, zvichiteerana. Chiyero chakanaka chekuongorora ropa remashiripiti uye serum CEA kune varwere vane danho reD uye danho A rakanga rakaderera zvikuru kupfuura iro kune varwere vane nhanho C uye D. Kwakange kusina kusiyana kwakasiyana muhuwandu hwakanaka hwe fecal calprotectin kune varwere vane zvikamu zvakasiyana-siyana Dukes.

Kunzwa kwefecal calprotectin kuongororwa kune rectal cancer yakasvika 92.7%, uye iyo yakaipa yekufungidzira kukosha kweNPV yakasvika 98.6%. Fecal calprotectin ye colorectal cancer, ≥10mm colorectal polyps yakazara yakaipa yekufungidzira kukosha NPV yakasvika 97.2%.

Kusvika pari zvino, nyika dzinopfuura makumi maviri dzakaita seUnited States, Britain, Canada, France, Germany, neSwitzerland dzakashandisa calprotectin sechiratidzo chakakosha chekuongorora chirwere chinoputika uye kenza muhuwandu hwehutachiona hwezvirwere zvematumbo, uye kuongororwa kuzvimba. bowel chirwere. Kushanda uye kuporesa zviratidzo zvakakosha zvinoshandiswa zvakanyanya mumakiriniki maitiro.

3, Zvakanakira zve calprotectin uye ropa remashiripiti rakasanganiswa kuona kwemukati kenza yekuongorora njodzi

1. Zviri nyore kushanda: imwe sampuli, akawanda bvunzo mhinduro
2. Haisi kuwedzera kuoma kwekushanda uye mutengo wechiridzwa: chiridzwa chinoiswa, uye midziyo inogadzirirwa maererano nezvinodiwa.
3. High senitivity uye chaiwo: kuzvimba index, gastrointestinal kubuda ropa
4. Yekutanga yekuongorora nhanho kumberi: wedzera mukana wekutarisa adenocarcinoma uye polyps
5. Mutengo wakaderera wekuona, unogona kushandiswa semvura yecolonoscopy
6. Kushingirira: gore negore batch kuongorora

Zviratidzo zvechirwere chegomarara remukati:

Kuzvimba kwematumbo - calprotectin, Dukes nhanho ndiyo nhanho A uye B varwere vane occult bvunzo yeropa uye serum CEA yakanaka mwero yakaderera zvakanyanya pane varwere vane C uye D nhanho, Dukes nhanho dzakasiyana dzemurwere, chiyero chakanaka chefecal calprotectin Misiyano yakakosha.

Kubuda ropa mudumbu - ropa remashiripiti, transferrin. Gastrointestinal hemorrhage inoreva kurasikirwa kweropa kuburikidza nemudumbu nekuda kwezvikonzero zvakasiyana. Zvinowanzokonzeresa zvinosanganisira kuzvimba kwegomba rekudya pacharo, kukuvara kwemuchina, chirwere chevascular, bundu, uye zvirwere zvevisceral mudumbu remudumbu. Kuongororwa kweropa remashiripiti inzira uye yakakosha nzira yekuongorora kubuda kweropa.

4, Nzira yekuona fecal calprotectin

Yedu calprotectin test kit (colloidal goridhe nzira) inogona kushandiswa yega kuona semi-quantitatively kuona calprotectin mumasampuli ezvituru zvevanhu. Inogona zvakare kushandiswa neWIZ yakatevedzana yeimmunoassays.

Iyo calprotectin assay kit (fluorescence immunochromatography) inogona kuwana kuwanda kwekuona, kwakaringana nhamba dzenhamba, uye yakakura mutsara mutsara, kuitira kuti uwane mhedzisiro yekusiyanisa zvirwere zvematumbo.

The occult ropa test kit (colloidal goridhe nzira) rinoshandiswa qualitative kuonekwa hemoglobin yevanhu mutsvina yevanhu, iyo yakakodzera kuongororwa kubuda ropa mudumbu.