Yakanyanya acute kufema syndrome coronavirus 2 (SARS-CoV-2), iyo inokonzeresa pathogen yeachangopfuura coronavirus chirwere 2019 (COVID-19) denda, ipfungwa yakanaka, ine tambo imwe chete RNA hutachiona hune genome saizi inosvika makumi matatu kb. . Mazhinji akasiyana eSARS-CoV-2 ane akasiyana masiginecha ekuchinja akabuda mudenda rose. Zvichienderana neayo spike protein mutational landscape, mamwe akasiyana aratidza kutapurirana kwakanyanya, kusatapukira, uye virulence.

Iyo BA.2.86 mutsara weSARS-CoV-2, iyo yakatanga kuzivikanwa muna Nyamavhuvhu 2023, yakasiyana nephylogenetically kubva kuOmicron XBB iri kutenderera iye zvino, kusanganisira EG.5.1 neHK.3. Mutsara weBA.2.86 une machinjiro anodarika makumi matatu muprotein spike, zvichiratidza kuti dzinza iri rinokwanisa zvikuru kunzvenga kudzivirirwa kwagara kuripo anti-SARS-CoV-2.

Iyo JN.1 (BA.2.86.1.1) ndiyo ichangobva kubuda musiyano weSARS-CoV-2 wakabva mumutsara weBA.2.86. Iyo JN.1 ine chiratidzo chekuchinja L455S mu spike protein uye mamwe matatu machinja mumaproteni asiri-spike. Zvidzidzo zvekuongorora HK.3 nezvimwe zvakasiyana-siyana zve "FLip" zvakaratidza kuti kuwana L455F mutation mu spike protein kunodyidzana nekuwedzera kutapurira kwehutachiwana uye kukwanisa kunzvenga kuzvidzivirira. Iyo L455F uye F456L shanduko dzakatumidzwa zita rekuti "Flip”shanduko nekuti vanochinja nzvimbo dzeamino acids maviri, akanyorwa F uye L, pane spike protein.

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