Fecal calprotectin (FC) ine 36.5 kDa calcium-binding protein inotora 60% ye neutrophil cytoplasmic proteins uye inounganidzwa uye inoshandiswa panzvimbo dzekuzvimba kwematumbo uye inoburitswa mutsvina.

FC ine zvakasiyana-siyana zvehupenyu zvipenyu, zvinosanganisira antibacterial, immunomodulatory, uye antiproliferative zviitiko. Kunyanya, kuvepo kweFC kunoenderana nehuwandu hwekufamba kweneutrophils mudumbu remukati. Naizvozvo, chiratidzo chinobatsira chekuzvimba kwemukati kuona kuvepo uye kuomarara kwekuzvimba muura.

Zvinogona kungotora matanho mana ekukura kubva mudumbu kuzvimba kuenda kugomarara: kuzvimba kwemukati -> intestinal polyps -> adenoma -> gomarara remukati. Izvi zvinotora makore kana makumi emakore, zvichipa mikana yakakwana yekuongorora kwekutanga kwezvirwere zvematumbo. Zvakadaro, nekuti vanhu vazhinji havatarise kuvhenekwa kwekutanga, nyaya zhinji dzegomarara remuura dzinoonekwa dzave padanho repamusoro.

Zvinoenderana nedata rine chiremera kumba nekune dzimwe nyika, iyo makore mashanu ekupona kwekutanga-danho colorectal cancer inogona kusvika 90% kusvika 95%. Kana iri carcinoma in situ (danho rekutanga), mwero wekurapa uri pedyo ne100%. Iwo makore mashanu ekupona kweanononoka-danho colorectal cancer ari pasi pegumi muzana. Aya data anoratidza zvakasimba kuti kuongororwa kwekutanga kwakakosha mukuvandudza kupona uye kurapa mitengo yevarwere vane cancer yemudumbu. Parizvino, dzimwe nyanzvi dzakataura kuti vanhuwo zvavo vanofanira kutanga vavhenekwa gomarara remuura mushure memakore makumi mana, uye vanhu vane nhoroondo yemhuri kana zvimwe zvinhu zvine njodzi vanofanirwa kutanga vavhenekwa.

Calprotectin yekuona reagentchinhu chisingarwadzi, chisingaiti, chiri nyore-kushanda chinoshandiswa kuongorora chiyero chekuzvimba kwematumbo uye kubatsira mukuongororwa kwezvirwere zvinokonzerwa nehutachiona hwehutachiona (chirwere chechirwere, adenoma, colorectal cancer). Kana kuongorora kwe calprotectin kusina kunaka, haufaniri kuita colonoscopy kwenguva. Kana mhedzisiro yebvunzo iri positive, usanyanya kutya. Mazhinji emashure-colonoscopy mhedzisiro ndeye precancerous maronda senge adenomas. Izvi zvipembenene zvinogona kugadziriswa zvinobudirira kuburikidza nekupindira kwekutanga.