Indwara ikabije y'ubuhumekero coronavirus 2 (SARS-CoV-2), nyirabayazana w'indwara ya coronavirus iheruka kwandura 2019 (COVID-19), ni virusi nziza ya virusi ya RNA ifite genome ingana na 30 kb . Impinduka nyinshi za SARS-CoV-2 zifite imikono itandukanye ihindagurika yagaragaye mu cyorezo cyose. Ukurikije imiterere ya spike protein ihinduka ryimiterere, ibintu bimwe na bimwe byagaragaje kwandura cyane, kwandura, na virusi.

Imirongo ya BA.2.86 ya SARS-CoV-2, yamenyekanye bwa mbere muri Kanama 2023, itandukanye na phylogeneque itandukanye na Omicron XBB ikwirakwizwa ubu, harimo EG.5.1 na HK.3. Imirongo ya BA.2.86 ikubiyemo ihinduka rirenga 30 muri poroteyine ya spike, byerekana ko uyu murongo ushoboye cyane kwirinda ubudahangarwa bwa anti-SARS-CoV-2.

JN.1 (BA.2.86.1.1) nuburyo bwa vuba bwagaragaye bwa SARS-CoV-2 bwakomotse kumurongo wa BA.2.86. JN.1 ikubiyemo ihinduka ryihariye rya L455S muri poroteyine ya spike hamwe nizindi mpinduka eshatu muri poroteyine zitari spike. Ubushakashatsi bwakozwe kuri HK.3 nubundi buryo bwa “FLip” bwerekanye ko kubona ihinduka rya L455F muri proteine ​​ya spike bifitanye isano no kwanduza virusi ndetse nubushobozi bwo kwirinda indwara. Ihinduka rya L455F na F456L ryiswe ”Flip ”ihinduka kuko bahindura imyanya ya acide ebyiri za amino, yanditseho F na L, kuri proteine ​​ya spike.

Twebwe ubuvuzi bwa baysen turashobora gutanga covid-19 yo kwipimisha kugirango ukoreshe urugo, ikaze kutwandikira kubindi bisobanuro.