Fecal calprotectin (FC) ni proteine ​​ya 36.5 kDa ya calcium ihuza bingana na 60% bya poroteyine ya neutrophil cytoplasmeque kandi ikusanyirizwa hamwe igakorerwa ahantu h'umuriro w'amara ikarekurwa mu mwanda.

FC ifite ibinyabuzima bitandukanye, harimo antibacterial, immunomodulatory, na antiproliferative. By'umwihariko, kuba FC ihari bifitanye isano no kwimuka kwa neutrophile mu nzira ya gastrointestinal. Kubwibyo, ni ikimenyetso cyingirakamaro cyo gutwika amara kugirango umenye ahari nuburemere bwumuriro mu mara.

Irashobora gufata intambwe enye gusa kugirango ikure kuva mu mara kugeza kanseri: gutwika amara -> polyps yo munda -> adenoma -> kanseri y'amara. Iyi nzira ifata imyaka cyangwa imyaka mirongo, itanga amahirwe ahagije yo gusuzuma hakiri kare indwara zo munda. Ariko, kubera ko abantu benshi batitaye kubisuzuma hakiri kare, abantu benshi barwara kanseri y'amara basuzumwa mugihe cyambere.

Dukurikije imibare yemewe mu gihugu ndetse no hanze yarwo, imyaka 5 yo kubaho kwa kanseri yo mu cyiciro cya mbere irashobora kugera kuri 90% kugeza 95%. Niba ari kanseri mu mwanya (icyiciro cya mbere), igipimo cyo gukira kiri hafi 100%. Ikigereranyo cyimyaka 5 yo kubaho kwa kanseri yibara itinze kiri munsi ya 10%. Aya makuru yerekana neza ko kwisuzumisha hakiri kare ari ngombwa mu kuzamura ubuzima no gukiza abarwayi barwaye kanseri y'amara. Kugeza ubu, abahanga bamwe basabye ko abantu basanzwe bagomba kwisuzumisha hakiri kare kanseri y'amara nyuma y’imyaka 40, kandi abantu bafite amateka y’umuryango cyangwa izindi mpamvu zishobora guteza ibyago byinshi bagomba kwisuzumisha hakiri kare.

Calprotectin detection reagentni ibicuruzwa bitababaza, bidatera, byoroshye-gukora-bikoreshwa mu gusuzuma urugero rwo gutwika amara no gufasha mu gusuzuma indwara ziterwa no gutwika amara (indwara zifata amara, adenoma, kanseri yibara). Niba ikizamini cya calprotectin ari kibi, ntukeneye gukora colonoskopi mugihe gito. Niba ibisubizo byikizamini ari byiza, ntugahagarike umutima cyane. Ibyinshi mubisubizo bya nyuma ya colonoskopi nibisebe byabanjirije nka adenoma. Ibi bisebe birashobora gucungwa neza binyuze mugutabara hakiri kare.