Pepsinogen Iamapangidwa ndi kutulutsidwa ndi maselo akuluakulu a oxyntic glandular dera la m'mimba, ndipo pepsinogen II imapangidwa ndikutulutsidwa ndi pyloric dera la m'mimba. Zonsezi zimasinthidwa kukhala ma pepsins mu lumen ya m'mimba ndi HCl yotulutsidwa ndi ma cell a fundic parietal.

1.Kodi pepsinogen II ndi chiyani?
Pepsinogen II ndi imodzi mwa ma proteinases anayi a aspartic: PG I, PG II, Cathepsin E ndi D. Pepsinogen II amapangidwa makamaka mu Oxyntic gland mucosa ya m'mimba, gastric antrum ndi duodenum. Imatulutsidwa makamaka mu lumen ya m'mimba ndi kuzungulira.
2.Kodi zigawo za pepsinogen ndi ziti?
Pepsinogens imakhala ndi unyolo umodzi wa polypeptide wokhala ndi molekyulu yolemera pafupifupi 42,000 Da. Ma pepsinogens amapangidwa ndikutulutsidwa makamaka ndi maselo am'mimba a m'mimba mwa munthu asanasandutsidwe kukhala proteolytic enzyme pepsin, yomwe ndi yofunika kwambiri pakugayitsa chakudya m'mimba.
3.Kodi pali kusiyana kotani pakati pa pepsin ndi pepsinogen?
Pepsin ndi enzyme ya m'mimba yomwe imathandizira kugaya mapuloteni omwe amapezeka muzakudya. Maselo akuluakulu am'mimba amatulutsa pepsin ngati zymogen yosagwira ntchito yotchedwa pepsinogen. Maselo a parietal mkati mwa chiberekero cha m'mimba amatulutsa hydrochloric acid yomwe imachepetsa pH ya m'mimba.

Diagnostic Kit ya Pepsinogen I/PepsinogenII (Fluorescence Immuno Assay)ndi fluorescence immunochromatographic assay pozindikira kuchuluka kwa PGI/PGII mu seramu yamunthu kapena plasma, Imagwiritsidwa ntchito makamaka powunika momwe gastric oxyntic gland cell imagwirira ntchito komanso matenda am'mimba fundus mucinous gland muchipatala.

Takulandilani kuti mumve zambiri.