Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2), choyambitsa matenda a coronavirus aposachedwa kwambiri 2019 (COVID-19) mliri, ndi kachilombo ka RNA kokhala ndi chingwe chimodzi chokhala ndi kukula kwa genome pafupifupi 30 kb. . Mitundu yambiri ya SARS-CoV-2 yokhala ndi siginecha yodziwika bwino yatulukira pa mliri wonse. Kutengera mawonekedwe awo amtundu wa spike protein mutational, zosintha zina zawonetsa kufalikira, kusakhazikika, komanso kuwopsa.

Mzere wa BA.2.86 wa SARS-CoV-2, womwe unadziwika koyamba mu Ogasiti 2023, ndi wosiyana kwambiri ndi mizere ya Omicron XBB yomwe ikuzungulira pano, kuphatikiza EG.5.1 ndi HK.3. Mzera wa BA.2.86 uli ndi masinthidwe opitilira 30 mu protein ya spike, zomwe zikuwonetsa kuti mzerewu utha kuthawa chitetezo chomwe chinalipo kale chotsutsana ndi SARS-CoV-2.

JN.1 (BA.2.86.1.1) ndi mtundu waposachedwa kwambiri wa SARS-CoV-2 womwe umachokera ku mzere wa BA.2.86. JN.1 ili ndi masinthidwe odziwika bwino a L455S mu puloteni ya spike ndi masinthidwe ena atatu m'mapuloteni omwe si a spike. Kafukufuku wofufuza za HK.3 ndi mitundu ina ya "FLip" awonetsa kuti kupeza kusintha kwa L455F mu protein ya spike kumalumikizidwa ndi kufalikira kwa ma virus komanso kuthekera kwa chitetezo chamthupi. Kusintha kwa L455F ndi F456L kumatchedwa "tembenuzani”masinthidwe chifukwa amasintha malo a ma amino acid awiri, otchedwa F ndi L, pa protein ya spike.

We baysen Medical itha kukupatsirani mayeso a covid-19 kuti mugwiritse ntchito kunyumba, talandilani kutiuza kuti mumve zambiri.