ZOFUNIKA KUGWIRITSA NTCHITO

Gastrin, yemwe amadziwikanso kuti pepsin, ndi mahomoni am'mimba omwe amapangidwa makamaka ndi ma G cell am'mimba antrum ndi duodenum ndipo amagwira ntchito yofunika kwambiri pakuwongolera magwiridwe antchito am'mimba ndikusunga dongosolo la m'mimba. Gastrin imatha kulimbikitsa katulutsidwe ka asidi m'mimba, imathandizira kukula kwa maselo am'mimba a mucosal, komanso kukonza zakudya komanso magazi a mucosa. Mu thupi la munthu, kuposa 95% ya biologically yogwira gastrin ndi α-amidated gastrin, yomwe makamaka imakhala ndi ma isomers awiri: G-17 ndi G-34. G-17 ikuwonetsa zomwe zili pamwamba kwambiri m'thupi la munthu (pafupifupi 80% ~ 90%). Kutulutsa kwa G-17 kumayendetsedwa mosamalitsa ndi pH ya m'mimba antrum ndipo kumawonetsa malingaliro oyipa omwe amagwirizana ndi asidi am'mimba.

Chidachi chimapangidwira kuti muzindikire mu vitro kuchuluka kwa zomwe zili mu Gastrin 17 (G-17) mu seramu yamunthu / plasma / magazi athunthu. Zidazi zimangopereka zotsatira zoyeserera za Gastrin 17 (G-17).