Pepsinogen I is synthesized and secreted by chief cells of the oxyntic glandular region of the stomach, and pepsinogen II is synthesized and secreted by the pyloric region of the stomach. Both are activated to pepsins in the gastric lumen by HCl secreted by fundic parietal cells.

1.What is pepsinogen II?
Pepsinogen II is one of four aspartic proteinases: PG I, PG II, Cathepsin E and D. Pepsinogen II is produced primarily in the Oxyntic gland mucosa of the stomach, the gastric antrum and the duodenum. It is secreted mainly into the gastric lumen and into circulation.
2.What are the components of pepsinogen?
Pepsinogens consist of a single polypeptide chain with a molecular weight of approximately 42,000 Da. Pepsinogens are synthesized and secreted primarily by the gastric chief cells of the human stomach before being converted into the proteolytic enzyme pepsin, which is crucial for digestive processes in the stomach.
3.What is the difference between pepsin and pepsinogen?
Pepsin is a stomach enzyme that serves to digest proteins found in ingested food. Gastric chief cells secrete pepsin as an inactive zymogen called pepsinogen. Parietal cells within the stomach lining secrete hydrochloric acid that lowers the pH of the stomach.

Diagnostic Kit for Pepsinogen I/ PepsinogenII ( Fluorescence Immuno Assay) is a fluorescence immunochromatographic assay for the quantitative detection of PGI/PGII in human serum or plasma, It is mainly used to evaluate gastric oxyntic gland cell function and gastric fundus mucinous gland disease in clinical.

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