SUMMARY

As an acute phase protein, serum amyloid A belongs to heterogeneous proteins of apolipoprotein family, which
has relative molecular weight of approx. 12000. Many cytokines are involved in the regulation of SAA expression
in acute phase response. Stimulated by interleukin-1 (IL-1), interleukin-6 (IL-6) and tumor necrosis factor-α
(TNF-α), SAA is synthesized by activated macrophages and fibroblast in liver, which has short half-life of only
around 50 minutes. SAA bonds with high-density lipoprotein (HDL) in blood rapidly upon synthesis in liver, which
needs to be degraded by serum, cell surface and intracellular proteases. In case of certain acute and chronic
inflammation or infection, degradation rate of SAA in body obviously slows down while synthesis increases,
which lead to continuous rise in SAA concentration in blood. SAA is an acute phase protein and inflammatory
marker synthesized by hepatocytes. SAA concentration in blood will increase within a couple of hours upon
occurrence of inflammation, and SAA concentration will experience 1000-times increase during acute
inflammation. Therefore, SAA can be used as an indicator of microbial infection or various inflammations, which
can facilitate diagnosis of inflammation and monitoring of therapeutic activities.

Our Diagnostic Kit for Serum Amyloid A (Fluorescence Immunochromatographic Assay) is applicable to in vitro quantitative detection of antibody to serum amyloid A (SAA) in human serum/plasma/whole blood sample, and it’s used for auxiliary diagnosis of acute and chronic inflammation or infection.

Welcome to contact for more details if you have interest.