Sepsis is known as the “silent killer”. It may be very unfamiliar to most people, but in fact it is not far away from us. It is the main cause of death from infection worldwide. As a critical illness, The morbidity and mortality rate of sepsis remain high. It is estimated that there are approximately 20 to 30 million sepsis cases worldwide every year, and one person loses his life almost every 3 to 4 seconds.

Since the mortality rate of sepsis increases by hours, time is of the essence in the treatment of sepsis, and early identification of sepsis has become the most critical part of treatment. In recent years, heparin-binding protein (HBP) has been proven to be one of the emerging markers for early diagnosis of bacterial infection, helping doctors to detect sepsis patients as early as possible and improve treatment effects.

• Bacterial & Viral Infection Identification

Because HBP begins to be released from the early stage of bacterial infection, HBP detection can provide early clinical treatment evidence, thereby reducing the incidence of severe bacterial infection and sepsis. Combined detection of HBP and commonly used inflammatory markers can also improve the diagnostic accuracy.

• Assessment of infection severity HBP

concentration is positively correlated with infection severity and can be used to assess infection severity.

• Guidance on drug use

HBP can cause vascular leakage and tissue edema. As a causative factor, it is a potential target for drugs such as heparin and albumin to treat organ dysfunction. Drugs such as albumin, heparin, hormones, simvastatin, tizosentan, and dextran sulfate can effectively reduce the level of plasma HBP in patients.

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