Pepsinogen IA na-emepụta ma na-ezobe ya site na sel ndị isi nke mpaghara oxyntic glandular nke afọ, na pepsinogen II na-emepụta na nzuzo site na mpaghara pyloric nke afọ. Ha abụọ na-arụ ọrụ na pepsins na gastric lumen nke HCl zoro ezo site na mkpụrụ ndụ parietal fundic.

1.Gịnị bụ pepsinogen II?
Pepsinogen II bụ otu n'ime proteinases aspartic anọ: PG I, PG II, Cathepsin E na D. A na-emepụta Pepsinogen II n'ụzọ bụ isi na mucosa Oxyntic gland nke afọ, antrum gastric na duodenum. A na-ezobe ya karịsịa n'ime lumen gastric na n'ime mgbasa.
2.Gịnị bụ akụkụ nke pepsinogen?
Pepsinogens nwere otu yinye polypeptide nwere nha molekụla dị ihe dịka 42,000 Da. A na-emepụta pepsinogens ma na-ezobe ya nke ọma site na isi sel afọ afọ nke afọ mmadụ tupu agbanwe ya na pepsin proteolytic, nke dị mkpa maka usoro mgbari nri na afọ.
3.Gịnị bụ ọdịiche dị n'etiti pepsin na pepsinogen?
Pepsin bụ enzyme afọ nke na-arụ ọrụ iji gbarie protein ndị a na-ahụ n'ime nri. Mkpụrụ ndụ ndị isi afọ na-ezobe pepsin dị ka zymogen na-adịghị arụ ọrụ nke a na-akpọ pepsinogen. Mkpụrụ ndụ parietal dị n'ime eriri afọ na-ezobe hydrochloric acid nke na-ebelata pH nke afọ.

Ngwa nyocha maka Pepsinogen I/ PepsinogenII (Fluorescence Immuno Assay)bụ nyocha nke fluorescence immunochromatographic maka nchọpụta ọnụọgụ nke PGI/PGII na ọbara mmadụ ma ọ bụ plasma, a na-ejikarị ya nyochaa ọrụ cell oxyntic gland na gastric fundus mucinous gland ọrịa na ụlọ ọgwụ.

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