Interleukin-6 bụ polypeptide nke nwere agbụ glycoprotein abụọ, nke nwere ihe dị arọ nke 130kd. Dị ka onye dị mkpa na netwọk cytokine, interleukin-6 (IL-6) na-ekere òkè dị mkpa na mmeghachi omume mkpali na-egbuke egbuke, ọ pụkwara imezi mmeghachi omume imeju na-akpali akpali, ma kpalie mmepụta protein C-reactive (CRP) na fibrinogen. Ọtụtụ ọrịa na-efe efe nwere ike ibute mmụba na ọkwa ọbara IL-6, yana ọkwa IL-6 jikọtara ya na nsonaazụ onye ọrịa. Dị ka cytokine pleiotropic nwere ọtụtụ ọrụ, IL-6 na-ezobe ya site na T cell, B cell, mononuclear phagocyte, na endothelial cell, na ọ bụ akụkụ bụ isi nke netwọk mgbasa ozi mkpali. Mgbe mmeghachi omume mkpali mere, IL-6 na-ebute ụzọ, nke na-ebute mmepụta nke CRP na procalcitonin (PCT) na mmepụta ya. A ga-emepụta ya ngwa ngwa n'ihe gbasara ọrịa, mmerụ ahụ dị n'ime na nke mpụga, ọrụ ịwa ahụ, mmeghachi omume nchekasị, ọnwụ ụbụrụ, ọrịa tumorigenesis, na nnukwu mmeghachi omume mkpali nke ọnọdụ ndị ọzọ. IL-6 na-etinye aka na omume na mmepe nke ọtụtụ ọrịa, ọkwa ọbara ya na-ejikọta ya na mbufụt, ọrịa nje na ọrịa autoimmune, mgbanwe ya na-eme tupu CRP. Dị ka nchọpụta nchọpụta si kwuo, ọkwa IL-6 na-abawanye ngwa ngwa n'elu nje bacteria, ọkwa PCT na-abawanye mgbe 2h gasịrị, ebe CRP na-abawanye ngwa ngwa mgbe 6h gasịrị. Ihe nzuzo nzuzo na-adịghị mma ma ọ bụ mkpụrụ ndụ ihe nketa nke IL-6 nwere ike ibute ọtụtụ ọrịa, nnukwu IL-6 nwere ike zoo n'ọbara na-ekesa na steeti pathological, na nchọpụta IL-6 dị oke mkpa maka nchọpụta ọrịa na ikpe amụma.