Fecal calprotectin (FC) yog 36.5 kDa calcium-binding protein uas suav nrog 60% ntawm cov protein neutrophil cytoplasmic thiab tau sau thiab qhib rau ntawm qhov chaw ntawm plab hnyuv thiab tso tawm rau hauv cov quav.

FC muaj ntau yam khoom siv roj ntsha, suav nrog cov kab mob tua kab mob, immunomodulatory, thiab kev ua haujlwm tiv thaiv kab mob. Tshwj xeeb, muaj FC muaj feem cuam tshuam nrog kev tsiv teb tsaws ntawm neutrophils mus rau hauv txoj hnyuv. Yog li ntawd, nws yog ib qho tseem ceeb cim ntawm txoj hnyuv o los txiav txim seb qhov muaj thiab qhov hnyav ntawm cov hnyuv.

Nws tsuas yog siv plaub kauj ruam los txhim kho los ntawm txoj hnyuv o mus rau mob qog noj ntshav: mob plab hnyuv -> plab hnyuv polyps -> adenoma -> mob qog noj ntshav. Cov txheej txheem no yuav siv sijhawm ntau xyoo lossis ntau xyoo, muab sijhawm txaus rau kev tshuaj xyuas ntxov ntawm cov kab mob hauv plab. Txawm li cas los xij, vim tias muaj coob tus neeg tsis xyuam xim rau kev tshuaj ntsuam thaum ntxov, ntau tus neeg mob qog noj ntshav tau kuaj pom nyob rau theem siab.

Raws li cov ntaub ntawv tso cai nyob hauv tsev thiab txawv teb chaws, 5-xyoo kev ciaj sia ntawm tus mob qog nqaij hlav ntxov ntxov tuaj yeem ncav cuag 90% txog 95%. Yog hais tias nws yog carcinoma nyob rau hauv situ (qhov ntxov tshaj plaws), tus nqi kho yog ze rau 100%. 5-xyoo kev ciaj sia ntawm tus mob qog nqaij hlav hauv plab yog tsawg dua 10%. Cov ntaub ntawv no qhia tau hais tias kev tshuaj xyuas ntxov yog qhov tseem ceeb rau kev txhim kho kev ciaj sia thiab kho tus nqi rau cov neeg mob qog noj ntshav. Tam sim no, qee cov kws tshaj lij tau hais tias cov tib neeg zoo tib yam yuav tsum tau kuaj xyuas ntxov rau mob qog noj ntshav tom qab hnub nyoog 40 xyoo, thiab cov neeg muaj keeb kwm hauv tsev neeg lossis lwm yam kev pheej hmoo siab yuav tsum tau kuaj xyuas ntxov.

Calprotectin nrhiav pom reagentyog ib yam khoom uas tsis muaj mob, tsis muaj kev cuam tshuam, yooj yim rau kev khiav lag luam khoom siv los soj ntsuam cov qib ntawm plab hnyuv o thiab pab rau kev kuaj mob ntawm plab hnyuv kab mob (mob plab hnyuv, adenoma, mob qog noj ntshav). Yog tias qhov kev kuaj calprotectin tsis zoo, koj tsis tas yuav ua ib qho kev kuaj colonoscopy rau lub sijhawm. Yog tias qhov ntsuas tau zoo, tsis txhob poob siab. Feem ntau ntawm cov txiaj ntsig tom qab colonoscopy yog cov kab mob precancerous xws li adenomas. Cov kab mob no tuaj yeem tswj tau zoo los ntawm kev cuam tshuam ntxov.