Fecal CalprotectinIb qho cuab yeej tseem ceeb rau kev kuaj mob sib txawv ntawm cov kab mob plab hnyuv qis

Hauv kev kho mob, kev kuaj mob ntawm cov kab mob plab hnyuv qis feem ntau muaj teeb meem, vim tias ntau yam kab mob (xws li kab mob inflammatory bowel, irritable bowel syndrome, thiab infectious enteritis) muaj cov tsos mob sib tshooj, ua rau kev sib txawv meej nyuaj tsuas yog raws li cov tsos mob hauv kev kho mob thiab kev kuaj mob niaj hnub.Fecal calprotectin (FC), ib qho biomarker uas tsis yog kev phais, muaj zog heev, tau ua pov thawj tias muaj txiaj ntsig zoo hauv kev kuaj mob sib txawv ntawm cov kab mob plab hnyuv qis hauv xyoo tas los no, ua ib qho cuab yeej zoo los pab txiav txim siab hauv kev kho mob.

Yog dab tsi Fecal Calprotectin?

Calprotectin yog ib qho protein pom nyob rau hauv cytoplasm ntawm neutrophils. Thaum mob plab hnyuv tshwm sim, neutrophils tsiv mus rau hauv plab hnyuv mucosa thiab tso calprotectin, ua rau muaj kev nce ntxiv hauv nws cov concentration hauv cov quav. Vim nws qhov ruaj khov siab thiab yooj yim ntawm kev kuaj pom, FC zoo cuam tshuam txog qib ntawm mob plab hnyuv, pab kom paub qhov txawv ntawm cov kab mob plab hnyuv (piv txwv li, IBD) thiab cov mob tsis mob (piv txwv li, IBS).

Cov ntawv thov hauv kev kuaj mob sib txawv

1. Kev sib txawv ntawm kab mob plab hnyuv (IBD) thiab mob plab hnyuv (IBS)
   IBD (xws li kab mob Crohn thiab ulcerative colitis) yog ib qho kab mob o ntawm txoj hnyuv ntev, thaum IBS yog ib qho kev mob nkeeg uas tsis muaj cov organic lesions. Cov theem FC feem ntau nce siab heev rau cov neeg mob IBD (feem ntau tshaj 100 μg/g), thaum cov neeg mob IBS feem ntau nyob hauv qhov ntau thiab tsawg (tsawg dua 50 μg/g). Yog li ntawd, kev kuaj FC tuaj yeem ua haujlwm ua cov cuab yeej tshuaj ntsuam kab thawj zaug, txo cov txheej txheem endoscopic tsis tsim nyog, txo cov nqi kho mob, thiab txhim kho kev kuaj mob zoo.
2. Kev ntsuam xyuas ntawm kev ua haujlwm ntawm tus kab mob IBD

Cov theem FC muaj feem cuam tshuam zoo rau kev ua haujlwm ntawm tus kab mob hauv IBD. Kev saib xyuas tas li ntawm FC pab soj ntsuam qhov ua tau zoo ntawm kev kho mob thiab kwv yees qhov rov qab los. Piv txwv li, qhov txo qis ntawm FC thaum lub sijhawm kho mob qhia txog kev o tuaj yeem tswj tau, thaum qhov nce ntxiv dua tuaj yeem qhia txog kev rov qab los ntawm tus kab mob, coj kev hloov kho hauv cov tswv yim kho mob.

3. Kev sib txawv ntawm cov kab mob kis tau los ntawm lwm yam kab mob inflammatory

Kab mob plab hnyuv uas kis tau los ntawm cov kab mob sib kis (xws li kab mob bacterial lossis viral enteritis) kuj tseem tuaj yeem ua rau FC nce siab, tab sis feem ntau cov qib qis dua li cov hauv IBD thiab txo qis sai sai thaum tus kab mob ploj mus. Kev saib xyuas FC tas li pab cais qhov sib txawv ntawm cov kab mob ib ntus thiab cov kab mob o ntev.

4. Kev Tshuaj Xyuas Pab Rau Mob Cancer Hauv Txoj Hnyuv Loj

Txawm hais tias FC tsis yog ib qho cim tshwj xeeb rau mob qog noj ntshav hauv plab hnyuv, cov qog nqaij hlav hauv plab feem ntau muaj cov kev mob o, ua rau FC nce me ntsis mus rau nruab nrab. Thaum ua ke nrog lwm yam kev kuaj mob (piv txwv li, colonoscopy), FC tuaj yeem muab cov kev nkag siab ntxiv txog kev kuaj mob.

Cov Zoo thiab Cov Kev Txwv

Kev kuaj Calprotectin hauv quav muaj cov txiaj ntsig xws li tsis muaj kev cuam tshuam, yooj yim siv, thiab tus nqi qis, ua rau nws tsim nyog rau kev tshuaj xyuas thawj zaug thiab kev saib xyuas mus sij hawm ntev. Txawm li cas los xij, siab duaFecal Cal tsis yog ib qho mob tshwj xeeb rau IBD thiab kuj pom tau rau lwm yam mob (xws li kev kis kab mob hauv plab hnyuv, qog nqaij hlav, thiab mob plab hnyuv uas siv tshuaj nonsteroidal anti-inflammatory drug). Yog li ntawd, yuav tsum muaj kev ntsuam xyuas kom meej raws li cov tsos mob hauv kev kho mob, kev kuaj mob endoscopic, thiab kev tshawb fawb txog kev siv duab.

Xaus lus

Fecal calprotectin Kev kuaj mob muab lub hauv paus tseem ceeb rau kev kuaj mob sib txawv ntawm cov kab mob plab hnyuv qis, tshwj xeeb tshaj yog pab cais IBD los ntawm IBS thiab ua kom zoo tshaj plaws kev kuaj mob thiab kev kho mob. Nrog kev nce qib hauv kev siv tshuab kuaj mob thiab kev siv tshuaj kho mob tob dua,cov tshuaj calprotectin hauv quav yuav ua lub luag haujlwm tseem ceeb hauv kev tswj kab mob plab hnyuv, muab kev kuaj mob thiab kev kho mob zoo dua thiab zoo dua rau cov neeg mob.

Los ntawm kev siv scientificcov tshuaj calprotectin hauv quavua ib lub cuab yeej, peb tuaj yeem pab tau zoo dua rau kev kuaj mob thiab pab tswj thiab kho cov kab mob plab hnyuv qis.

Baysen Kho Mobyeej ib txwm tsom mus rau kev kuaj mob kom txhim kho lub neej zoo. Peb tau tsim 5 lub platform thev naus laus zis - Latex, colloidal gold, Fluorescence Immunochromatographic Assay, Molecular, Chemiluminescence Immunoassay. Peb muaj Kev kuaj mob sai CalprotectinthiabKuvkev kuaj Calprotectin mmunoassay rau kev tshuaj xyuas kev raug mob raum theem thaum ntxov.