Non-Invasive Testing Breakthrough:Fecal Calprotectin"Crosses Ciam Tebchaws" los pab kuaj ntxov ntxov ntawm Upper GI Inflamation hauv menyuam yaus

Hauv kev kuaj mob rau menyuam yaus cov kab mob digestive system, endoscopy tau ntev dhau los ua "tus qauv kub" rau kev txiav txim siab txog kev mob plab hnyuv. Txawm li cas los xij, qhov kev ntsuam xyuas no tsis yog tsuas yog nrog lub cev tsis xis nyob rau cov menyuam yaus, tshwj xeeb tshaj yog cov hluas, tab sis feem ntau ua rau muaj kev ntshai ntawm kev puas siab puas ntsws loj thiab nyuaj rau kev koom tes. Qhov no ua rau ntau tus niam txiv tsis txaus siab thaum kuaj thawj zaug thiab tej zaum yuav plam lub sijhawm rau kev cuam tshuam ntxov. Tsis ntev los no, kev tshawb fawb kho mob tshiab thiab kev xyaum ua haujlwm tau coj cov xov xwm zoo siab:Fecal calprotectin (FCP), ib tug paub tab uas tsis yog-invasive taw qhia rau kev ntsuam xyuas ntawm cov kab mob hauv plab hnyuv, yog qhia tau hais tias muaj peev xwm loj nyob rau hauv cov kev tshawb fawb ntxov ntawm cov kab mob plab hnyuv siab raum rau cov me nyuam, ua tiav ib qho zoo heev "crossover" los ntawm "cov hnyuv qis" mus rau "cov hnyuv sab sauv".

Los ntawm qhov teeb meem ntawm "Gold Standard" mus rau Kaj ntug ntawm Tsis-Invasive Test

Cov kab mob plab sab sauv xws li gastritis thiab gastroduodenitis tsis tshua muaj tshwm sim hauv cov menyuam yaus, thiab lawv cov ua rau muaj xws li kab mob, tshuaj, thiab kev ntxhov siab. Kev lig kev cai, kev kuaj mob yuav tsum tau saib xyuas qhov muag thiab cov ntaub so ntswg biopsy los ntawm gastroscopy, uas yog txheej txheem nyuaj thiab cuam tshuam. Txoj kev tshawb nrhiav tsis muaj kev cuam tshuam thiab yooj yim tau ib txwm yog qhov kev cia siab ntawm cov kws kho mob thiab tsev neeg ntawm cov menyuam muaj tus kabmob.Fecal calprotectin tshuajyog ib qho protein uas qhia txog neutrophil aggregation. Thaum lub plab hnyuv mucosa yog o, nws cov concentration yuav nce ntau. Tau ntau xyoo, nws tau siv dav hauv kev ntsuas kev ua haujlwm ntawm cov kab mob plab hnyuv siab raum (IBD) thiab kev kuaj mob sib txawv ntawm kev mob plab plob tsis so tswj (IBS), feem ntau yog rau txoj hnyuv loj.

Kev tshawb fawb tshawb fawb tau lees paub lub hauv paus ruaj khov rau "kev hla ciam teb" daim ntawv thov

Kev loj hlob lub cev ntawm kev tshawb fawb qhia tau hais tias tus kab mob no tsis yog tshwj xeeb rau txoj hnyuv. Thaum muaj kev mob tshwm sim tshwm sim nyob rau hauv lub plab hnyuv siab raum (xws li lub plab thiab duodenum), inflammatory cells kuj infiltrate thiab tso tawm.tshuaj calprotectin. Cov protein no nkag mus rau hauv lub plab zom mov nrog rau cov kua dej hauv plab thiab cov zaub mov seem, thaum kawg raug kuaj pom hauv cov quav. Cov kev tshawb fawb tsis ntev los no hauv cov menyuam yaus tau pom tiascalprotectin tshuajqib siab dua hauv cov menyuam yaus uas muaj qhov endoscopically paub tseeb tias gastritis lossis duodenitis piv rau cov uas muaj kev ua haujlwm dyspepsia lossis qhov kev tshawb pom endoscopic ib txwm muaj.Txawm hais tias cov qib FC nce siab los ntawm kev mob plab hnyuv feem ntau qis dua cov neeg mob IBD, lawv tau pom qhov sib txawv tseem ceeb piv rau cov neeg noj qab haus huv. Qhov no qhia tau hais tias kev kuaj FC tuaj yeem siv los ua qhov kev tshuaj ntsuam xyuas zoo los pab cov kws kho mob thawj zaug txheeb xyuas cov menyuam yaus uas muaj kev pheej hmoo siab ntawm cov kab mob plab hnyuv loj ntawm cov menyuam yaus uas muaj cov tsos mob xws li mob plab, plab, thiab xeev siab.

Clinical Value: Tsim kom muaj txoj hauv kev zoo rau kev kuaj mob rau menyuam yaus

Daim ntawv thov hla ciam teb ntawmcalprotectin tshuajtau coj ntau yam txiaj ntsig rau kev kuaj mob thiab tswj cov kab mob plab hnyuv siab rau cov menyuam yaus:

1. Tsis muaj kev cuam tshuam thiab ua raws siab: Tsuas yog ib qho me me ntawm cov quav quav yuav tsum tau, thiab cov txheej txheem tsis muaj kev cuam tshuam, uas txo qis lub cev thiab lub siab lub ntsws rau menyuam yaus. Cov niam txiv tau txais txiaj ntsig zoo ntawm cov txheej txheem, ua rau nws yooj yim rau kev soj ntsuam sai dua hauv cov chaw kho mob sab nraud.
2. Kev tshuaj ntsuam xyuas zoo thiab cov cuab yeej triage: Rau cov menyuam yaus uas muaj cov tsos mob plab tsis tu ncua,Fecal Calprotectinkev ntsuam xyuas tuaj yeem ua tau ua ntej kom sib txawv ntawm cov kab mob inflammatory thiab kev ua haujlwm zoo. YogFecal calprotectin tshuajcov qib yog ib txwm, cov yam ntxwv ua haujlwm tuaj yeem ua qhov tseem ceeb lossis kev kho mob empirical thiab kev soj ntsuam tuaj yeem txais yuav. Yog tias qib FC tau nce siab, nws muab lub hauv paus muaj zog rau kev cuam tshuam gastroscopy, zam cov txheej txheem endoscopic tsis tsim nyog thiab ua kom zoo rau kev faib cov peev txheej kho mob.
3. Kev ntsuam xyuas kev ua tau zoo thiab rov ua dua: Tom qab kev kuaj mob ntawm cov plab hnyuv siab raum thiab pib kho, dynamic saib xyuas cov kev hloov hauvFecal Calprotectincov qib tuaj yeem ua tus taw qhia lub hom phiaj rau kev ntsuas seb qhov mob puas tau txo qis thiab seb qhov kev kho mob puas zoo. Nws tseem tuaj yeem pab txhawm rau txheeb xyuas tus kab mob rov tshwm sim ntxov.

Yav tom ntej Outlook

Tau kawg, daim ntawv thov ntawm fecal calprotectin nyob rau hauv lub plab hnyuv sab sauv tseem xav tau kev tshawb fawb ntxiv kom meej meej nws cov txiaj ntsig zoo txiav tawm thiab txiav txim siab lwm yam hauv plab hnyuv uas tuaj yeem ua rau siab FC. Txawm li cas los xij, raws li txoj kev kuaj xyuas kev nyab xeeb, yooj yim, thiab tus nqi qis, nws yuav tsum qhib lub qhov rooj tshiab rau kev kuaj mob ntxov ntawm kev mob plab hnyuv hauv cov menyuam yaus. Nws cim ib kauj ruam tom ntej hauv kev kuaj mob ntawm cov menyuam yaus cov kab mob digestive mus rau tib neeg txoj hauv kev ntau dua thiab meej. Peb ntseeg tias nrog kev tshawb fawb tob tob thiab kev paub txog kev kho mob,calprotectin tshuaj,lub hnub qub "crossover", yuav ua lub luag haujlwm tseem ceeb hauv kev tiv thaiv menyuam txoj kev noj qab haus huv.

Baysen Medical yeej ib txwm tsom rau cov txheej txheem kuaj mob txhawm rau txhim kho lub neej zoo. Peb tau tsim 5 thev naus laus zis platforms- Latex, colloidal kub, Fluorescence Immunochromatographic Assay, Molecular, Chemiluminescence Immunoassay.Peb muaj Colloidal KubFecal calprotectin tshuaj Cov khoom siv kuaj thiab Fluorescence ImmunoassayCalprotectin kuaj cov khoom sivrau kev sim