Pepsinogen IHoʻopili ʻia a hūnā ʻia e nā keʻena nui o ka ʻāpana oxyntic glandular o ka ʻōpū, a ʻo ka pepsinogen II ua synthesized a huna ʻia e ka ʻāpana pyloric o ka ʻōpū. Hoʻohana ʻia nā mea ʻelua i nā pepsins i loko o ka lumen ʻōpū e ka HCl huna ʻia e nā cell parietal fundic.

1. He aha ka pepsinogen II?
ʻO Pepsinogen II kekahi o nā proteinases aspartic ʻehā: PG I, PG II, Cathepsin E a me D. Pepsinogen II ua hana nui ʻia i loko o ka mucosa Oxyntic gland o ka ʻōpū, ka antrum gastric a me ka duodenum. Ua huna nui ia i loko o ka ʻōpū o ka ʻōpū a i ke kahe.
2. He aha nā ʻāpana o ka pepsinogen?
ʻO nā Pepsinogens kahi kaulahao polypeptide hoʻokahi me ke kaumaha molekala ma kahi o 42,000 Da. Hoʻopili ʻia nā Pepsinogens a hūnā ʻia e nā ʻōpū poʻokela o ka ʻōpū o ke kanaka ma mua o ka hoʻololi ʻia ʻana i loko o ka pepsin enzyme proteolytic, he mea koʻikoʻi ia no nā kaʻina hana ʻai i loko o ka ʻōpū.
3. He aha ka ʻokoʻa ma waena o ka pepsin a me ka pepsinogen?
ʻO ka Pepsin kahi enzyme o ka ʻōpū e hoʻoheheʻe i nā protein i loaʻa i loko o ka meaʻai. Hoʻokuʻu ʻia ka pepsin ma ke ʻano he zymogen hana ʻole i kapa ʻia ʻo pepsinogen. ʻO nā pūnaewele parietal i loko o ka ʻōpū o ka ʻōpū e hūnā i ka waika hydrochloric e hoʻohaʻahaʻa i ka pH o ka ʻōpū.

ʻO ka pahu diagnostic no ka Pepsinogen I/ PepsinogenII (Fluorescence Immuno Assay)he fluorescence immunochromatographic assay no ka quantitative detection of PGI / PGII i loko o ke kanaka serum a i ʻole plasma, Ua hoʻohana nui ʻia e loiloi i ka hana o ka oxyntic gland cell function a me ka gastric fundus mucinous gland maʻi i ka maʻi.

Welina mai e kelepona no nā kikoʻī hou aku.