ʻO C-Reactive Protein (CRP) he pūmua i hana ʻia e ke ake, a piʻi nui kona mau pae i loko o ke koko i ka pane ʻana i ka mumū. ʻO kona loaʻa ʻana i ka makahiki 1930 a me ka noiʻi ʻana ma hope ua hoʻopaʻa ʻia kāna kuleana ma ke ʻano he mea koʻikoʻi a hoʻohana nui ʻia nā biomarkers i ka lāʻau lapaʻau hou. ʻO ke koʻikoʻi o ka hoʻāʻo ʻana CRP aia i kāna pono ma ke ʻano he mea maʻalahi, ʻoiai ʻaʻole kikoʻī, hōʻailona o ka mumū, kōkua i ka maʻi maʻi, stratification pilikia, a me ka nānā ʻana i kahi ʻano nui o nā kūlana.

1. He Hoailona Pilikino no ka Ma'i a me ka Ma'i
ʻO kekahi o nā noi mua o ka CRP i ka ʻike a me ka mālama ʻana i nā maʻi, ʻoi aku ka maʻi bacterial. ʻOiai ʻo ka piʻi ʻana o ka CRP he pane maʻamau i ka mumū, hiki ke piʻi i nā pae i nā maʻi bacterial koʻikoʻi, ʻoi aku ma mua o 100 mg/L. He mea nui kēia i ka hoʻokaʻawale ʻana i ka maʻi bacteria mai nā maʻi viral, ʻoiai ʻo ia ka mea maʻamau ke kumu i kahi kiʻekiʻe haʻahaʻa. I loko o nā hoʻonohonoho lapaʻau, hoʻohana ʻia ka CRP e ʻike i nā kūlana e like me ka maʻi pneumonia, sepsis, a me nā maʻi post-surgical. No ka laʻana, ʻo ka nānā ʻana i nā pae CRP ma hope o ke kaʻa ʻana e kōkua i nā kauka e ʻike i nā pilikia e like me nā maʻi ʻeha a i ʻole nā ​​abscesses hohonu i ka wā mua, e ʻae ana i ka hana koke. He mea kōkua nō hoʻi ia i ka mālama ʻana i nā maʻi ʻehaʻeha e like me ka rheumatoid arthritis a me ka maʻi ʻāʻī o ka ʻōpū (IBD), kahi e kōkua ai nā ana serial e ana i ka hana maʻi a me ka pono o ka lāʻau anti-inflammatory.

2. Ka Loiloi Pilikia Cardiovascular: hs-CRP
ʻO kahi holomua nui ma ke kula ʻo ka hoʻomohala ʻana i ka hoʻāʻo CRP (hs-CRP) kiʻekiʻe. ʻO kēia ho'āʻo e ana i nā haʻahaʻa haʻahaʻa loa o CRP, i ʻike ʻole ʻia ma mua. Ua hoʻokumu ʻia ka noiʻi ʻana ʻo ka ʻaʻa haʻahaʻa haʻahaʻa i loko o nā paia arterial ke kumu nui o ka atherosclerosis-ʻo ke kūkulu ʻana o ka plaque hiki ke alakaʻi i ka hōʻeha puʻuwai a me ka hahau ʻana. ʻO ka hs-CRP he mea biomarker ikaika no kēia maʻi vascular lalo.
Ua ʻike ka American Heart Association i ka hs-CRP ma ke ʻano he kumu kūʻokoʻa kūʻokoʻa no ka maʻi cardiovascular. ʻO ka poʻe me nā pae hs-CRP i ka pae kiʻekiʻe-maʻamau (ma luna o 3 mg/L) i manaʻo ʻia e piʻi aʻe ka pilikia no nā hanana naʻau e hiki mai ana, ʻoiai inā he maʻamau ko lākou kolamu. No laila, hoʻohana ʻia ka hs-CRP e hoʻomaʻemaʻe i ka loiloi pilikia, ʻoi aku hoʻi no nā maʻi maʻi waena. Hāʻawi kēia i nā hoʻolālā pale pilikino, e like me ka hoʻomaka ʻana i ka statin therapy i nā poʻe i ʻole e mālama ʻia ma muli o nā kumu pilikia kuʻuna wale nō.

3. Ka nānā ʻana i ka pane lapaʻau a me ka wānana
Ma waho aʻe o ka hōʻoia ʻana a me ka loiloi pilikia, ʻo CRP kahi mea hana maikaʻi loa no ka nānā ʻana i ka pane o ka mea maʻi i ka mālama ʻana. I nā maʻi maʻi maʻi, ʻo ka hāʻule ʻana o ka pae CRP he hōʻailona ikaika ia e pono ai ka lāʻau antibiotic a antimicrobial paha. Pēlā nō, i nā kūlana autoimmune, hoʻopili ka emi ʻana o ka CRP me ka hoʻopau kūleʻa ʻana o ka mumū e nā lāʻau immunosuppressive. ʻO kēia ʻano ikaika e hiki ai i nā kauka ke hoʻoponopono i nā hoʻolālā lapaʻau i ka manawa maoli. Eia kekahi, pili pinepine nā pae CRP kiʻekiʻe me ka wānana ʻoi aku ka maikaʻi o nā kūlana mai ka maʻi maʻi a hiki i ka pau ʻole o ka naʻau, e hāʻawi ana i ka puka makani i ka paʻakikī a me ke alahele o ka maʻi.

Nā palena a me ka hopena
ʻOiai kona pono, ʻo kahi palena koʻikoʻi o CRP ʻo kona ʻano kikoʻī ʻole. ʻO kahi pae kiʻekiʻe e hōʻike ana i ka hele ʻana o ka mumū akā ʻaʻole ia e kuhikuhi i ke kumu. ʻO ke kaumaha, ka trauma, ka momona, a me nā kūlana maʻi hiki ke hoʻokiʻekiʻe i ka CRP. No laila, pono e wehewehe mau ʻia kāna mau hopena i loko o ka pōʻaiapili o ka mōʻaukala lapaʻau o ka mea maʻi, ka hoʻokolokolo kino, a me nā ʻike diagnostic ʻē aʻe.

I ka hopena, ʻo ke koʻikoʻi o ka hoʻāʻo CRP he multifaceted. Mai ka hana ʻana ma ke ʻano he hoʻāʻo mua no nā maʻi koʻikoʻi a hiki i ka lawelawe ʻana ma ke ʻano he wānana maʻalahi no ka loaʻa ʻana o ka maʻi cardiovascular ma o ka hs-CRP, ʻo kēia biomarker he mea pono loa ia i ka waihona o ke kauka. ʻO kona hiki ke ana pono a nānā i ka mumū ua hoʻomaikaʻi nui i ka mālama maʻi i ka maʻi maʻi, alakaʻi mālama, a me ka loiloi prognostic ma waena o nā loea lapaʻau.