ʻO Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), ke kumu kumu o ka maʻi maʻi coronavirus hou loa 2019 (COVID-19) maʻi maʻi maʻi, he maʻi RNA stranded hoʻokahi me ka nui genome ma kahi o 30 kb . Nui nā ʻano like ʻole o SARS-CoV-2 me nā pūlima mutational ʻokoʻa i puka mai i loko o ka maʻi maʻi. Ma muli o kā lākou spike protein mutational landscape, ua hōʻike kekahi mau ʻano like ʻole i ka transmissibility kiʻekiʻe, infectivity, a me ka virulence.

ʻO ka laina BA.2.86 o SARS-CoV-2, ka mea i ʻike mua ʻia ma ʻAukake 2023, he phylogenetically ʻokoʻa mai nā laina o Omicron XBB e holo nei, me EG.5.1 a me HK.3. Aia ma ka laina BA.2.86 ma mua o 30 mau hoʻololi i loko o ka protein spike, e hōʻike ana he hiki i kēia laina ke pale aku i ka pale anti-SARS-CoV-2 mua.

ʻO ka JN.1 (BA.2.86.1.1) ka mea hou loa i puka mai o SARS-CoV-2 i iho mai ka hanauna BA.2.86. Aia i loko o ka JN.1 kahi hoʻololi L455S i loko o ka protein spike a me ʻekolu mau hoʻololi ʻē aʻe i nā protein non-spike. Ua hōʻike ʻia nā haʻawina e noiʻi ana iā HK.3 a me nā ʻano ʻokoʻa ʻē aʻe "FLip" i ka loaʻa ʻana o ka hoʻololi ʻana o L455F i loko o ka protein spike e pili ana me ka hoʻonui ʻana i ka viral transmissibility a me ka hiki ke pale aku. Ua kapa ʻia ka L455F a me F456L mutations "Flip”nā hoʻololi ʻana no ka mea ua hoʻololi lākou i nā kūlana o ʻelua amino acids, i kapa ʻia ʻo F a me L, ma ka protein spike.

Hiki iā mākou nā lāʻau lapaʻau baysen ke hāʻawi i ka hoʻāʻo pilikino covid-19 no ka hoʻohana ʻana i ka home, e ʻoluʻolu e kelepona iā mākou no nā kikoʻī hou aku.