ʻO Fecal calprotectin (FC) he 36.5 kDa calcium-binding protein e helu ana no 60% o nā protein cytoplasmic neutrophil a ua hōʻiliʻili ʻia a hoʻāla ʻia ma nā wahi o ka ʻōpū o ka ʻōpū a hoʻokuʻu ʻia i loko o nā feces.

Loaʻa iā FC nā ʻano mea olaola like ʻole, me nā hana antibacterial, immunomodulatory, a me nā hana antiproliferative. ʻO ka mea nui, pili ka nui o ka FC i ka neʻe ʻana o nā neutrophils i loko o ka gastrointestinal tract. No laila, he hōʻailona maikaʻi ia o ka ʻāʻī o ka ʻōpū e hoʻoholo ai i ka hele ʻana a me ka paʻakikī o ka mumū i loko o ka ʻōpū.

ʻEhā mau ʻanuʻu wale nō paha e hoʻomohala ʻia mai ka ʻāʻī ʻana a hiki i ka maʻi kanesa: ʻeha ʻōpū -> polyps intestinal -> adenoma -> maʻi maʻi ʻōpū. ʻO kēia kaʻina hana he mau makahiki a he mau makahiki paha, e hāʻawi ana i nā manawa kūpono no ka nānā mua ʻana i nā maʻi ʻōpū. Eia nō naʻe, no ka nui ʻole o ka poʻe i hoʻolohe ʻole i ka nānā mua ʻana, nui nā maʻi o ka maʻi maʻi ʻōpū i ʻike ʻia ma kahi pae kiʻekiʻe.

Wahi a ka ʻikepili mana ma ka home a ma waho, hiki i ka 5 mau makahiki ke ola o ka maʻi maʻi colorectal ma mua o ka manawa hiki ke piʻi i 90% a 95%. Inā he carcinoma in situ (ka pae mua loa), kokoke i ka 100%. ʻO ka nui o ke ola o 5 mau makahiki o ka maʻi maʻi colorectal hope loa ma lalo o 10%. Ke hōʻike ikaika nei kēia mau ʻikepili he mea koʻikoʻi ka hoʻomaʻamaʻa mua ʻana i ka hoʻomaikaʻi ʻana i ke ola a me nā helu hoʻōla no nā maʻi me ka maʻi maʻi ʻōpū. I kēia manawa, ua manaʻo kekahi poʻe loea e hoʻopaʻa mua ʻia ka poʻe maʻamau no ka maʻi maʻi ʻōpū ma hope o ke 40 o nā makahiki, a ʻo ka poʻe me ka mōʻaukala ʻohana a i ʻole nā ​​​​mea koʻikoʻi koʻikoʻi e hoʻopaʻa mua ʻia.

Calprotectin mea hoʻopaʻa ʻikehe mea ʻeha ʻole, non-invasive, maʻalahi e hoʻohana ʻia e loiloi i ke kiʻekiʻe o ka ʻōpū o ka ʻōpū a kōkua i ka ʻike ʻana i nā maʻi e pili ana i ka ʻōpū (ka maʻi ʻeha, adenoma, colorectal cancer). Inā maikaʻi ʻole ka hōʻike calprotectin, ʻaʻole pono ʻoe e hana i kahi colonoscopy no ka manawa. Inā maikaʻi ka hopena hōʻike, mai hopohopo. ʻO ka hapa nui o nā hopena post-colonoscopy he mau maʻi precancerous e like me adenomas. Hiki ke hoʻoponopono maikaʻi ʻia kēia mau ʻeha ma o ka hana mua ʻana.