Feritin: He Biomarker wikiwiki a pololei no ka nānā ʻana i ka nele o ka hao a me ka anemia

Hoʻolauna

ʻO ka nele o ka hao a me ka anemia nā pilikia olakino maʻamau i ka honua holoʻokoʻa, ʻoi aku hoʻi i nā ʻāina e ulu ana, nā wahine hāpai, nā keiki a me nā wahine hānau keiki. ʻAʻole pili wale ka Iron Deficiency Anemia (IDA) i ka hana kino a me ka noʻonoʻo o kēlā me kēia kanaka, akā hiki ke hoʻonui i ka pilikia o ka hoʻopiʻi hāpai ʻana a me ka lohi o ka ulu ʻana o nā keiki. No laila, pono ka nānā mua ʻana a me ka hana ʻana. Ma waena o nā hōʻailona ʻike he nui, ua lilo ka ferritin i mea hana koʻikoʻi no ka nānā ʻana i ka hemahema o ka hao a me ka anemia ma muli o kona ʻike kiʻekiʻe a me ka kikoʻī. E kūkākūkā kēia ʻatikala i nā hiʻohiʻona ola o ka ferritin, kāna mau mea maikaʻi i ka ʻike ʻana i ka hemahema o ka hao a me ka anemia, a me kāna waiwai noi.

Nā ʻano olaola oFeritin

Feritinhe pūmua mālama hao i loaʻa i loko o nā ʻiʻo kanaka. Hoʻohui nui ʻia e ka ate, ka ʻōpū a me ka iwi iwi. ʻO kāna hana nui ka mālama ʻana i ka hao a hoʻoponopono i ke koena o ka metabolism hao. I loko o ke koko, ka nui o kaferritinpili maikaʻi me nā mālama hao o ke kino. No laila, serumferritinʻO nā pae kekahi o nā hōʻailona koʻikoʻi o ke kūlana mālama hao o ke kino. Ma lalo o nā kūlana maʻamau, ʻo ka pae ferritin i nā kāne makua ma kahi o 30-400 ng / mL, a i nā wahine he 15-150 ng / mL, akā i ka hihia o ka hao hao, e hoʻemi nui ʻia kēia waiwai.

Pono oFeritini ka Hao Deficiency Screening

1. ʻO ka naʻau kiʻekiʻe, ʻike mua i ka hemahema o ka hao

Ua māhele ʻia ka ulu ʻana o ka hao i ʻekolu mau ʻāpana:

• Ke kahua hemahema hao: hao mālama(ferritin) emi iho, akā he mea maʻamau ka hemoglobin;
• ʻO ka pae erythropoiesis nele i ka hao:ferritine emi hou ana, e emi ana ka saturation transferrin;
• Ka pae anemia nele i ka hao: emi iho ka hemoglobin, a puka mai na hoailona anemia maʻamau.

Hiki ke ʻike i nā pilikia ma ka pae anemia ma nā ʻano hana kuʻuna (e like me ka hemoglobin testing).ferritinHiki i ka ho'āʻo ke ʻike i nā mea ʻino i ka wā mua o ka nele o ka hao, no laila e hāʻawi ana i kahi manawa no ka hana mua.

2. Kūlana Kiʻekiʻe, Hoʻemi i ka Misdiagnosis

Hiki i nā maʻi he nui (e like me ka mumū mau a me ka maʻi) ke hoʻoulu i ka anemia, akā ʻaʻole ia i kumu no ka nele o ka hao. I kēia hihia, ʻo ka hilinaʻi wale ʻana i ka hemoglobin a i ʻole mean corpuscular volume (MCV) hiki ke kuhi hewa i ke kumu.FeritinHiki i ka ho'āʻo ke hoʻokaʻawale pololei i ka anemia hemahema hao mai nā ʻano anemia ʻē aʻe (e like me ka anemia o ka maʻi maʻi mau), e hoʻomaikaʻi ana i ka pololei diagnostic.

3. ʻO ka wikiwiki a me ka maʻalahi, kūpono no ka nānāʻana i ka nui

ʻO ka ʻenehana hoʻāʻo biochemical hou ka mea e ʻoi aku ka wikiwiki o ka hoʻoholo ʻana i ka ferritin a ʻoi aku ka waiwai, a kūpono i nā papahana olakino lehulehu e like me ka nānā ʻana i ke kaiāulu, mālama olakino makuahine a me nā pēpē, a me ka nānā ʻana i ka meaʻai keiki. Ke hoʻohālikelike ʻia me nā hoʻāʻo invasive e like me ka hoʻopaʻa ʻana i ka hao iwi (gold standard), ʻoi aku ka maʻalahi o ka hoʻāʻo ʻana i ka serum ferritin.

Nā noi lapaʻau o Ferritin i ka hoʻokele anemia

1. Ke alakaʻi nei i ka lāʻau hoʻohui hao

FeritinHiki i nā pae ke kōkua i nā kauka e hoʻoholo inā pono nā mea maʻi i ka hoʻohui hao a nānā i ka pono o ka mālama ʻana. ʻo kahi laʻana:

• Feritin<30 ng/mL: hōʻike i ka pau ʻana o ka hao a pono ke hoʻonui ʻia ka hao;
• Feritin<15 ng/mL: hōʻike ikaika i ka anemia hemahema hao;
• Ke holo pono ka lapaau, ferritin E piʻi mālie nā pae a hiki ke hoʻohana ʻia e loiloi i ka pono

1. Ke alakaʻi nei i ka hoʻohui hao

Feritinkōkua nā pae i nā kauka e hoʻoholo i ka pono o ka lāʻau lapaʻau a nānā i ka pono o ka mālama ʻana. ʻo kahi laʻana:

• Feritin<30 ng/mL: Hōʻike i nā hale kūʻai hao i pau, e koi ana i ka hoʻohui.
• Feritin<15 ng/mL: Hōʻike ikaika i ka anemia hemahema hao.
• I ka wā lapaʻau, piʻiferritinhōʻoia nā pae i ka hopena therapeutic.

2. Ka nānā ʻana i nā heluna kanaka kūikawā

• Nā wāhine hāpai: piʻi ka koi hao i ka wā hāpai, aferritinhiki i ka hoʻāʻo ʻana ke pale i nā pilikia o ka makuahine a me ka pēpē.
• Nā keiki: ʻo ka nele o ka hao e pili ana i ka ulu ʻana o ka naʻau, a hiki i ka nānā mua ʻana ke hoʻomaikaʻi i ka wānana.
• ʻO nā maʻi me nā maʻi maʻi: e like me nā maʻi me nā maʻi maʻi a me nā maʻi ʻeha,ferritin hui pū me ka transferrin saturation hiki ke ʻike i ke ʻano o ka anemia.

Ka palena oFeritinKa ho'āʻo a me ka hoʻonā

ʻOiai ʻo ka ferritin ka hōʻailona maikaʻi loa no ka nānā ʻana i ka hemahema o ka hao, pono e unuhi ʻia me ka akahele i kekahi mau hihia:

• ʻO ka ʻā a i ʻole ka maʻi:Feritin, ma ke ʻano he protein reactant phase acute, hiki ke hoʻokiʻekiʻe wahaheʻe ʻia i ka maʻi, ka maʻi maʻi a i ʻole ka mumū mau. I kēia hihia, hiki ke hui pū meC-reactive protein (CRP) ortransferrinsaturation no ka hoʻoholo piha.
• ʻO ka maʻi ate:Feritini ka poʻe maʻi me ka cirrhosis hiki ke hoʻonui ma muli o ka pōʻino o ke akepaʻa a pono e loiloi ʻia me ka hui pū ʻana me nā mea hōʻailona iron metabolism.

Ka hopena

FeritinUa lilo ka ho'āʻo ʻana i mea paahana koʻikoʻi no ka nānā ʻana i ka hemahema o ka hao a me ka anemia ma muli o kona ʻano kiʻekiʻe, kikoʻī a me ka maʻalahi. ʻAʻole hiki ke ʻike wale i ka hemahema o ka hao a pale aku i ka holomua o ka anemia, akā alakaʻi pū i ka mālama kūpono a hoʻomaikaʻi i ka prognosis maʻi. Ma ke olakino lehulehu a me ka hana lapaʻau, ka hoʻolaha ʻana oferritin Hiki i ka ho'āʻo ʻana ke kōkua i ka hoʻēmi ʻana i ke kaumaha o ka maʻi anemia hemahema, ʻoi aku hoʻi no nā hui koʻikoʻi (e like me nā wahine hāpai, nā keiki a me nā maʻi me nā maʻi maʻi mau). I ka wā e hiki mai ana, me ka holomua o ka ʻenehana ʻike,ferritin Hiki paha ke hana nui i ka pale ʻana a me ka mālama ʻana i ka anemia honua.

Ke nānā mau nei mākou ʻo Baysen Medical i ka ʻenehana diagnostic e hoʻomaikaʻi i ka maikaʻi o ke ola. Ua hoʻomohala mākou i nā ʻenehana ʻenehana 5- Latex, colloidal gula, Fluorescence Immunochromatographic Assay, Molecular, Chemiluminescence Immunoassay, kā mākoupahu ho'āʻo Ferritin hana maʻalahi a hiki ke loaʻa ka hopena hōʻike ma 15 mins