ʻO ka holomua o ka hoʻāʻo ʻana ʻaʻole invasive:Fecal Calprotectin"Keʻaʻa i nā palena" e kōkua i kaʻike muaʻana o ka maʻi GI kiʻekiʻe i nā keiki

Ma ke kahua o ka hoʻomaʻamaʻa ʻana i nā maʻi pediatric digestive system, ua lōʻihi ka endoscopy i ka "standard gula" no ka hoʻoholo ʻana i ka mumū o ka ʻōpū o luna. Eia naʻe, ʻaʻole hele pū ʻia kēia hoʻokolohua invasive me ka ʻeha kino o nā keiki, ʻoi aku ka ʻōpio, akā lawe pinepine ʻia ka makaʻu noʻonoʻo nui a me ka paʻakikī i ka hui pū ʻana. ʻO kēia ka mea e kānalua ai nā mākua he nui i ka wā o ka ʻike mua ʻana a nalo paha ka manawa kūpono no ka hana mua ʻana.fecal calprotectin (FCP), He mea hōʻailona oʻoʻole no ka loiloiʻana i nā maʻi o ka'ōpū haʻahaʻa, e hōʻike ana i ka mana nui i kaʻike muaʻana o ka mumū o ka'ōpū o luna i nā keiki, e loaʻa ai kahi "crossover" maikaʻi mai ka "intestine lalo" a i ka "intestine luna".

Mai ka Dilemma o ka "Gold Standard" a i ka wanaʻao o ka hoʻāʻo non-invasive

ʻAʻole maʻamau ka ʻeha o ka ʻōpū o luna e like me ka gastritis a me ka gastroduodenitis i nā keiki, a ʻo kā lākou kumu e pili ana i ka maʻi, nā lāʻau lapaʻau, a me nā hopena koʻikoʻi. ʻO ka mea maʻamau, pono ka ʻike maka ʻike a me ka biopsy kiko ma o ka gastroscopy, he hana paʻakikī a invasive. ʻO nā ala ʻike ʻole-invasive a maʻalahi hoʻi ka manaʻo maʻamau o nā kauka a me nā ʻohana o nā keiki me ka maʻi.Fecal calprotectinhe pūmua e hōʻike ana i ka hōʻuluʻulu neutrophil. Ke hoʻoulu ʻia ka mucosa gastrointestinal, e hoʻonui nui ʻia kona ʻike. I loko o nā makahiki, ua hoʻohana nui ʻia i ka loiloi hana o ka maʻi ʻāʻī o ka ʻōpū (IBD) a me ka hōʻailona ʻokoʻa o ka maʻi ʻeha o ka ʻōpū (IBS), ka mea nui no ka mumū o ka colon.

Hōʻoia ka noiʻi ʻepekema i kahi kumu paʻa no nā noi "cross-border".

Ke hōʻike nei ka nui o ka noiʻi ʻana ʻaʻole wale kēia māka inflammatory i ke kolonā. I ka wā e puka mai ai ka mumū ikaika i loko o ka ʻōpū o ka ʻōpū o luna (e like me ka ʻōpū a me ka duodenum), komo pū a hoʻokuʻu ʻia nā cell inflammatory.calprotectin. Hele kēia pūmua i lalo o ka digestive tract me nā wai hoʻoheheʻe a me nā koena meaʻai, a ʻike ʻia i loko o ka waihona. Ua hōʻike ʻia nā haʻawina hou i nā keikifecal calprotectinʻoi aku ka kiʻekiʻe o nā pae i nā keiki me ka maʻi gastritis a i ʻole duodenitis i hoʻopaʻa ʻia endoscopically i hoʻohālikelike ʻia i ka poʻe me ka dyspepsia hana a i ʻole nā ​​​​hopena endoscopic maʻamau. Hōʻike kēia e hiki ke hoʻohana ʻia ka hoʻāʻo ʻana o FC ma ke ʻano he mea hana hoʻomaʻamaʻa maikaʻi e kōkua i nā kauka e ʻike mua i nā keiki i ka nui o ka maʻi o ka ʻōpū o ka ʻōpū o luna i waena o ka nui o nā keiki e hōʻike ana i nā hōʻailona e like me ka ʻeha o ka ʻōpū, ka ʻōpū, a me ka nausea.

Waiwai Hoʻomaʻamaʻa: Ke kūkulu ʻana i kahi ala ʻoi aku ka maikaʻi o ka Diagnostic Pediatric

ʻO ka noi palena palena ofecal calprotectinua lawe mai i nā pono he nui i ka ʻike a me ka mālama ʻana i nā maʻi o ka ʻōpū o luna i nā keiki:

1.Non-invasive a me ka kiʻekiʻe ka hoʻokō: He mea liʻiliʻi wale nō o ka stool hāpana e koi ʻia, a ʻo ke kaʻina hana ʻaʻole loa i hoʻopilikia ʻia, ka mea e hōʻemi nui ai i ke kaumaha kino a me ka noʻonoʻo i nā keiki. ʻAe nui nā mākua i ke kaʻina hana, e maʻalahi ke hana wikiwiki i ka nānā pinepine ʻana i nā keʻena maʻi outpatient.
2. He mea paahana pono no ka nana ana a me ka hoao ana: No na keiki me na ma'i ma'i o ka ma'i mau,Fecal Calprotectinhiki ke hana mua i ka ho'āʻo e hoʻokaʻawale maikaʻi ma waena o nā maʻi ʻeha a me nā maʻi hana. InaFecal calprotectinHe mea maʻamau nā pae, hiki ke hoʻonohonoho mua ʻia nā mea hana a i ʻole ka hoʻomaʻamaʻa empirical a hiki ke ʻae ʻia ka nānā. Inā hoʻokiʻekiʻe ʻia nā pae FC, hāʻawi ia i kumu ikaika no ka gastroscopy invasive, e pale ana i nā kaʻina hana endoscopic pono ʻole a me ka hoʻonui ʻana i ka hoʻokaʻawale ʻana i nā kumuwaiwai olakino.
3. Ka loiloi kōkua ʻana i ka pono a me ka hoʻi hou ʻana: Ma hope o ka ʻike ʻana i ka ʻeha o ka ʻōpū o luna a me ka hoʻomaka ʻana o ka mālama ʻana, nānā ikaika i nā loliFecal CalprotectinHiki ke hoʻohana ʻia nā pae ma ke ʻano he hōʻailona kuhikuhi no ka loiloi ʻana inā ua emi ka mumū a inā he maikaʻi ka lāʻau. Hiki ke kōkua i ka ʻike mua ʻana i ka hoʻi hou ʻana o ka maʻi.

Manao e hiki mai ana

ʻO kaʻoiaʻiʻo, ʻo ka hoʻohana ʻana i ka fecal calprotectin ma ka ʻōpū o ka ʻōpū o luna e koi hou aku i ka noiʻi e wehewehe pono i kona waiwai cutoff maikaʻi loa a hoʻokuʻu i nā mea ʻai haʻahaʻa haʻahaʻa e hoʻonui ai i ka FC. Eia naʻe, ma ke ʻano he palekana, maʻalahi, a me ke kumu kūʻai haʻahaʻa, wehe ʻo ia i kahi puka hou no ka ʻike mua ʻana o ka maʻi ʻōpū o luna i nā keiki. Hōʻailona ia i kahi ʻanuʻu i mua i ka ʻike ʻana i nā maʻi digestive pediatric i kahi ala ʻoi aku ke kanaka a me ka pololei. Manaʻo mākou me ka hoʻomau ʻana i ka noiʻi hohonu a me ka hōʻiliʻili ʻana i ka ʻike lapaʻau,fecal calprotectin,ʻO kēia "hoku crossover," e pāʻani i kahi hana koʻikoʻi i ka pale ʻana i ke olakino digestive o nā keiki.

Ke nānā mau nei ʻo Baysen Medical i ka ʻenehana diagnostic e hoʻomaikaʻi i ka maikaʻi o ke ola. Ua hoʻomohala mākou i nā ʻenehana ʻenehana 5- Latex, colloidal gula, Fluorescence Immunochromatographic Assay, Molecular, Chemiluminescence Immunoassay. Loaʻa iā mākou Colloidal GoldFecal calprotectin pahu ho'āʻo a me Fluorescence Immunoassaypahu ho'āʻo Calprotectinno ka hoao ana