2.Your vaguely offensive use of the term “cult”: I went to the trouble of checking the definition in the Oxford dictionary: cult NOUN • 1A system of religious veneration and devotion directed towards a particular figure or object. ‘the cult of St Olaf’

"Also, not everyone is responsive to steroids and within that non-responsive group there is a lot of morbidity."

“Racing is such a fantastic environment to drive endeavour and creativity,” said Whitmarsh. “[At McLaren] we realised we’ve got a machine here that attracts really bright, ambitious, competitive people. It promotes invention, it creates IP and enables us to grow capability, so we took that from a motor-racing business with about 80 people to a business of about 3,500 people and a series of technology businesses that had been grown off the back of that. We’re very focused on trying to win the America’s Cup – that’s where our brand is going to be grown – but it’s clear to me that the marine sector is a number of years behind aero and motorsport with regards to control systems, hydraulics, simulation, analysis. I think there’s an incredible opportunity to go out and do those things.”

Background: Inhaled mannitol is a new bronchial provocation test (BPT) developed to improve portability and standardisation of osmotic challenge testing. Osmotic challenge tests have an advantage over the traditional methods of measuring airway hyperresponsiveness using methacholine as they demonstrate higher specificity to identify asthma and thus the need for treatment with inhaled corticosteroids (ICS). The safety and the efficacy of mannitol (M) as a BPT to measure airway hyperresponsiveness were compared to hypertonic (4.5%) saline (HS) in people both with and without signs and symptoms of asthma. Methods: A phase III, multi-centre, open label, operator-blinded, crossover design, randomised trial, with follow-up. Asthmatics and non-asthmatics (6-83yr) were recruited and 592 subjects completed the study. Mannitol was delivered using a low resistance dry powder inhaler and HS was delivered using an ultrasonic nebuliser. The FEV1 was measured 60 seconds after each dose of mannitol (5,10,20,40,80,160,160,160 mg) and after each exposure to HS (0.5,1.0,2.0,4.0,8.0 minutes). A 15% fall in FEV1 defined a positive test. Adverse events were monitored and diaries kept for 7 days following the tests. Results: Mean pre-test FEV1 (mean±SD) was 95.5±14% predicted. 296 were positive to mannitol (M+) and 322 positive to HS (HS+). A post study physician conducted clinical assessment identified 82.3% asthmatic (44% classified mild) and 17.7% non-asthmatic. Of those M+, 70.1% were taking ICS and of those mannitol negative (M-), 81.1% were taking ICS. The % fall in FEV1 for mannitol in asthmatics was 21.0%±5.7 and for the non-asthmatics, 5.5%±4.8. The median PD15 M was 148mg and PD15 HS 6.2ml. The sensitivity of M to identify HS+ was 80.7% and the specificity 86.7%. The sensitivity of M compared with the clinical assessment was 59.8% and specificity 95.2% and increased to 88.7% and 95.0% respectively when the M- subjects taking ICS were excluded. Cough was common during testing. There were no serious adverse events. The diarised events were similar for mannitol and HS, the most common being headache (17.2%M, 19%HS), pharyngolaryngeal pain (5.1%M, 3%HS), nausea (4.3%M, 3%HS), and cough (2.2%M, 2.4%HS). Conclusions: The efficacy and safety of mannitol was demonstrated in non-asthmatic and clinically diagnosed asthmatic adults and children. © 2005 Brannan et al., licensee BioMed Central Ltd.

The Lady Bears are 18th in the USA Today/National Fastpitch Coaches Association Coaches poll and 19th in the ESPN.com/USA Softball Collegiate poll.

The expressions of TXNIP, TRX, p-NF-κBp65, NF-κBp65, p-IκBα, IκBα, p-IKKα, IKKα, p-IKKβ, and IKKβ, p-ERK, ERK, p-JNK, JNK, p-P38, and P38 in the VB-treated rats (400 mg/kg) were assessed by Western blot analysis. For the TXNIP/TRX/NF-κB pathway, the increase of TXNIP, p-NF-κBp65, p-IKKα, p-IKKβ, and the decrease of TRX in heart tissue, were presented quite clearly. For the MAPK/NF-κB pathways, p-ERK, p-JNK, and p-P38 showed an apparent increase in levels (Fig. 6). Additionally, the enhanced expression of TXNIP, p-NF-κBp65, p-IκBα, p-IKKα, and p-IKKβ in VB(400 mg/kg)-treated rats were clearly observed at 4–48 h by immunohistochemistry (Fig. 7).

"I think for physicians and patients, the key question when deciding whether to screen for prostate cancer or not is, Can I decide not to treat if I am diagnosed with a low-risk cancer?" she said.

https://www.theguardian.com/global/commentisfree/2018/jan/18/fear-donald-trump-us-president-art-of-the-deal

Obesity is now recognised as a worldwide epidemic. The recent International Association for the Study of Obesity/International Obesity Taskforce (IASO/IOTF) analysis estimates tha… [more]

Assays were conducted as recommended by the manufacturers, and the cutoffs for the interpretations of the serologic values for adults are the following: positive, ≥9; negative, ≤6; equivocal, between 6 and 9. Those for infants are the following: positive, ≥3; negative, <3.

Pearson’s Correlation Coefficients was used to assess the colocalization of two protein obseved in confocal microscope. This index is a measure of the strength and direction of the linear relationship between two variables that is defined as the (sample) covariance of the variables divided by the product of their (sample) standard deviations. Formula is shown was followed

Kupzig, S. et al. Bst-2/HM1.24 is a raft-associated apical membrane protein with an unusual topology. Traffic 4, 694–709 (2003).