Henke, A., Huber, S., Stelzner, A. & Whitton, J. L. The role of CD8+ T lymphocytes in coxsackievirus B3-induced myocarditis. J Virol. 69, 6720–6728 (1995).
© 2016 Asian Pacific Society of Respirology Background and objective: Obesity is an established risk factor for poor health outcomes, but paradoxically in chronic obstructive pulmonary disease (COPD), it is associated with improved survival and lung function. A major evidence gap exisits to inform treatment recommendations for patients with COPD who are obese. We aimed to determine the effect of weight reduction involving a low-energy diet utilizing a partial meal replacement plan, coupled with resistance exercise training in obese COPD patients. Methods: In a proof of concept before¿after clinical trial, obese (body mass index =30 kg/m2) COPD patients received a 12 week weight reduction programme involving meal replacements, dietary counselling by a dietitian and resistance exercise training prescribed and supervised by a physiotherapist. Patients were reviewed face to face by the dietitian and physiotherapist every 2 weeks for counselling. Results: Twenty-eight participants completed the intervention. Mean (standard deviation) body mass index was 36.3 kg/m2 (4.6) at baseline and reduced by 2.4 kg/m2 ((1.1) P < 0.0001) after the intervention. Importantly, skeletal muscle mass was maintained. Clinical outcomes improved with weight loss including exercise capacity, health status, dyspnea, strength and functional outcomes. There was also a significant reduction in the body mass index, obstruction, dyspnea and exercise score (BODE). Systemic inflammation measured by C-reactive protein however did not change. Conclusion: In obese COPD patients, dietary energy restriction coupled with resistance exercise training results in clinically significant improvements in body mass index, exercise tolerance and health status, whilst preserving skeletal muscle mass. This novel study provides a framework for development of guidelines for the management of obese COPD patients and in guiding future research.
Wells, T. N. Natural products as starting points for future anti-malarial therapies: going back to our roots? Malar J 10 Suppl 1, S3 (2011).
There is convincing evidence that PSA-based screening leads to substantial over-diagnosis of prostate tumors. Many tumors will not harm patients, while the risks of treatment are significant. Physicians should not offer or order PSA screening unless they are prepared to engage in shared decision making that enables an informed choice by patients.
© 2016 AMPCo Pty Ltd. Produced with Elsevier B.V. All rights reserved. Coal workers¿ pneumoconiosis (CWP) is an untreatable but preventable lung disease arising from chronic inhal… [more]
ABPA is an important complication of chronic asthma resulting from hypersensitivity to the fungus Aspergillus Fumigatus ( AF}. ABPA is characterised by an intense immune response … [more]
First major evidence-based text in adult respiratory medicine. Comprehensive, authoritative summary of the best treatments for the major respiratory diseases. Compiled by specialists from the Cochrane Airways Management Group. Easy-to-use format, with key clinical implications summarised in each chapter. Kept up-to-date online: Compiled by specialists from the Cochrane Collaboration Airways Management Group, Evidence-based Respiratory Medicine is the first major evidence-based text in adult respiratory medicine. Providing a comprehensive summary of the best treatments for the most important respiratory diseases, some of the world’s leading physicians review the evidence for a broad range of treatments using evidence-based principles. Essential information is presented in an easy-to-understand format, with the most important clinical implications summarised in each chapter. Evidence-based Respiratory Medicine tackles the big clinical questions in diagnosis and treatment, presenting treatment options which take into account the individual patient’s needs. Evidence-Based Series:Evidence-based Respiratory Medicine, part of the acclaimed series BMJ Evidence-based medicine textbooks that have revolutionised clinical medicine literature, comes with a fully searchable CD-ROM of the whole text. Note: CD-ROM/DVD and other supplementary materials are not included as part of eBook file. © 2005 by Blackwell Publishing Ltd.
© 2016 American College of Chest Physicians Background Asthma and COPD are common airway diseases. Individuals with overlapping asthma and COPD experience increased health impairm… [more]
Shave, R., Ross, P., Low, D., George, K. & Gaze, D. Cardiac troponin I is released following high-intensity short-duration exercise in healthy humans. Int J Cardiol. 145, 337–339, doi: 10.1016/j.ijcard.2009.12.001 (2010).
Another important relationship is with industrial giant Siemens, which has supplied an end-to-end suite of software tools that has enabled the team to create a true digital twin of the real-life boat.
The indigenous inhabitants of geographic Palestine have a long history in geographic Palestine. To assert that all people in the world – citizens of homelands all over the world – who have chosen to embrace the religion-based identity of Jewish have “a 3,000 year history” in geographic Palestine is an insult to rational thought.
© 2014 Asian Pacific Society of Respirology. Background and objective While weight loss has been shown to reduce obesity-related comorbidity, many weight loss treatments fail. Fac… [more]
Many older men still getting PSA test for prostate cancer, against recommendations | Calprotectin Elisa Kit Related Video:
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